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NMDA
Drugs that affect NMDA receptors
9
Pharmacology
Graduate
12/13/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Glutamate/Aspartate
Definition
Endogenous NMDA receptor complex aganists. Only works when co-aganist glycine is bound. Opens Ca and Na channels.
Term
Zinc
Definition

Endogenous NMDA receptor complex antaganist.

 

Occupies Side position on the receptor and prevents the flow of Ca and Na ions.

Term
Magnesium
Definition

Endogenous NMDA receptor complex antaganist.

 

Actually blocks the Channel and prevents the flow of Ca and Na ions.

 

It is thought that the binding of NMDA actually causes the release of Mg from the channel.   

Term
Glycine
Definition

Endogenous NMDA receptor complex aganist in the brain only (acts as inhibtor in the spine).

 

Only works when co-aganist Glutamate or Asparate are bound.

 

Opens Ca and Na channels.

Term
Memantine
Definition

Non-competative NMDA antagonist

 

blocks/unblocks channel like Mg but does so more rapidly.

 

 

treats dimentia/CNS problems in the elderly

Term

Methadone

(Dolophine)

Definition

u-opioid receptor aganist and NMDA antagonist

 

both work as analgesic agents

Term
Lamotrigine
Definition

 

Anti-epileptic

 

Na-Channel Blocker

 

Glutamate-release inhibitor

(results in reduction of NMDA receptor activity)

 

 

Term
Felbamate
Definition

Glycine (NMDA)-antagonist

(GABA-aganist)

 

Anti-epileptic

 

not used due to high liver toxicity

Term
Topiramate
Definition

Anti-epileptic

 

AMPA-Antagonist/GABA-Aganist

 

make you loose weight

can help in pain relief/migraines

Impairs memory

Myopia & Galucoma

Inhibts Carbonic anhydrase

(prevents soda from tasting good)

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