Term
| Non-depolarizing NM Blockers |
|
Definition
| COMPETITIVE Ach antagonists at the nicotinic rec of the NM jtc |
|
|
Term
|
Definition
1. mm of fine movement (eyes, fingers...)
2. Limbs
3. Trunk
4. Intercostals
5. Diaphragm
*Recovery in reverse order |
|
|
Term
| Non-dep. NM Blocker side effects |
|
Definition
Ganglionic blockade => dec BP
Histamine release => dec BP, bronchospasm, inc secretions
Muscarininc rec blockade => tachy |
|
|
Term
|
Definition
|
|
Term
| d-Tubocurarine pharmacokinetics |
|
Definition
Renal elimination
Half-life 3 hrs |
|
|
Term
| d-Tubocurarine side effects |
|
Definition
dec BP
bronchospasm
inc secretions |
|
|
Term
|
Definition
Non-depol NM blocker
NOT renal elim, hepatic
Intermediate duration, longer in elderly, not much longer in renal failure |
|
|
Term
|
Definition
Non-depol NM blocker
NOT renal, spontaneous breakdown and plasma elimination
Intermediate duration in all pts |
|
|
Term
|
Definition
non-depol NM blocker
NOT renal elim, plasma esterases
SHORTEST duration of action |
|
|
Term
|
Definition
non-depol NM blocker
Renal elim
Inc duration in elderly and renal failure |
|
|
Term
| Non-depol NM blocker rx interactions |
|
Definition
Enhanced activity w:
Aminoglycosides
Ca channel blockers
certain Inhalation anesthetics
Recovery can be hastened w cholinesterase inh |
|
|
Term
|
Definition
Depolarizes post-syn cell for extended period of time
Succinylcholine |
|
|
Term
| Depol NM blockers rx interactions |
|
Definition
Early in block- Cholinesterase inh INTENSIFY block
Late in block- Cholinesterase inh may partially REVERSE block |
|
|
Term
|
Definition
|
|
Term
| Succinylcholine side effects (4) |
|
Definition
Myalgia
Cardiac arrythmias due to K release from sk m
Prolonged paralysis
Malignant hyperthermia (rare) |
|
|
Term
| Succinylcholine contraindications (4) |
|
Definition
Pts w extensive burns or soft tissue damage
Paraplegics
Duchenne's MD
Children except in emergencies |
|
|
Term
| Rx for malignant hyperthermia |
|
Definition
|
|
Term
|
Definition
GABAb rec agonist
Musc relaxant used to rx spasticity a/w MS, or SpCd injury or dz, trig. neuralgia |
|
|
Term
|
Definition
Musc relaxant used to rx malignant hyperthermia
Inh Ca release from the SR in sk m |
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