Term
| Guillain-Barré syndrome? |
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Definition
| inflammatory process (typically a week or two after a viral infection) causes macrophage degradation of myelin. Patients become weaker over a period of ~1 week. Ascending pattern. Complete paralysis possible with ventilation needed. Most recover in weeks to months |
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Term
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Definition
- Autoimmune disease that causes macrophage demyelination of CNS white matter.
- periodic occurrences
- can happen anywhere, but common locations are: optic nerve, deep cerebral white matter (around ventricles), cerebellar peduncles, brainstem and spinal chord/
- thought to be genetic-environment interaction
- relatively common esp in young adults |
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Term
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Definition
| blocks voltage gated Na+ channels |
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Term
| hyperkalemic periodic paralysis |
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Definition
| mutation in voltage-gated Na+ channels don't inactivate after depolarization. When extracellular K+ increases, cells depolarize and remain depolarized and nonfunctional for minutes to hours |
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Term
| Thomsen's and Becker's disease? |
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Definition
| muscle cells use Cl- maintain resting membrane potential way more than nerves, so they need Cl- permeability. Cl- channels are mutated and muscle cells end up shooting off a train of action potentials after a single depolarization. It also makes the threshold lower. Same result occurs if you bath muscle cells in a Cl- free solution with impermeable anions |
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Term
| Kinesin moves ___. Dynein moves ____. |
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Definition
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