Term
| what is the time frame for metabotropic and ionotropic receptors |
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Definition
| seconds to minutes and milliseconds, respectively |
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Term
| cardiac muscarinic receptors work by... |
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Definition
| acetylcholine binds GPCR --> beta-gamma subunit binding K+ channel and opening it --> decreases basal rate of depolarization |
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Term
| cardiac Beta-adrenergic receptors work by... |
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Definition
| NE binds GPCR-->alpha subunit activates adenylate cyclase --> cAMP activates PKA --> phosphorylates Ca++ channel, which causes it to open. |
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Term
| mechanism of 5-HT receptor: |
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Definition
| 5-HT (seratonin) binds 5HT-GPCR --> Alpha subunit activates AC --> cAMP activates PKA --> PKA phosphorylates normally open K+ channel in presynaptic terminal, closing it --> increases neurotransmitter release |
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Term
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Definition
| Alpha subunit activates PLC-->PIP2 cleaved to IP3 and DAG -->IP3 binds to IP3 receptor and releases Ca++ from endoplasmic reticulum |
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Term
| FMRFamide receptor mechanism |
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Definition
| FMRFamide binds-->PLA2 activated by alpha subunit-->arachidonic acid liberated and metabolized to 12-HPETE-->12-HPETE opens S-type K+ channel |
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Term
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Definition
| Ca++ activate PLD in the postsynaptic neuron generates anandamide-->diffuses back across synapse and binds to cannabinoid receptor (CB1, a GPCR)-->inhibits Ca++ channels, and thus glutamate release and EPSP amplitude |
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Term
| glutamate activates 3 ____ receptors as well as ____ receptors. It is responsible for ___ of EPSPs in the brain |
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Definition
| ionotropic (AMPA, NMDA, Kainate); metabotropic; 90% |
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Term
| at what potential is the Mg++ pushed out of NMDAR? |
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Definition
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