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Neuroscience test 4
FINAL Dr. O
113
Medical
Graduate
05/01/2013

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Cards

Term
Facts and events (what kind of memory)
Definition
declarative (explicit) memory
Term
procedural memory- routines, skills, habits (muscle and emotional memory too)
Definition
nondeclarative (implicit) memory
Term
Forget things you already knew
Definition
retrograde amnesia
Term
Inability to form new memories
Definition
anterograde amnesia
Term
Symptoms: Disoriented, ask same questions repeatedly; Attacks subside in couple of hours; Permanent memory gap
Definition
transient global amnesia
Term
Who stimulated the temporal lobe to elicit past memories and experiences?
Definition
Dr. Wilder Graves Penfield
Term
effect of a temporal lobectomy (HM)
Definition
Anterograde amnesia so profound cannot perform basic human activities (and partial retrograde amnesia). Does not affect intelligence or personality.
Term
Medial temporal lobes
Definition
Important for consolidating memories
Term
Lesions to striatum
Definition
cause deficits in procedural memory
Term
Caudate nucleus + Putamen =
Definition
striatum
Term
function of prefrontal cortex
Definition
self-awareness, capacity for planning and problem solving
Term
Where do learning and memory occur in the brain?
Definition
throughout the brain! but primarily in hippocampus
Term
T/F- multitasking is possible
Definition
False- you cannot truly focus on multiple activities or things at the same time. you are quick at changing your attention during "multi-tasking"
Term
How does Ritalin work?
Definition
it is a mild central nervous system stimulant. It also inhibits the dopamine transporter, increasing the postsynaptic effect of dopamine.
Term
State of selectively processing simultaneous sources of information
Definition
attention
Term
in the experiment with a computer on measuring the effect of attention on visual detection, what were the findings and what did each of the symbols mean?
Definition
The findings were that individuals can focus their attention without changing their eye pattern. It is easier to detect a valid cue (one that has meaning) than an invalid cue.

+=neutral sign
arrow to the right, with circle on the right=valid
arrow to the right with circle to the left=invalid cue
Term
T/F- Attention can alter the speed of visual processing or the time it takes to make a decision.
Definition
True (most likely)
Term
What part of the brain is most likely damaged in neglect syndrome?
Definition
the RIGHT cerebral cortex (lesions of the posterior parietal cortex), affecting the left visual field.
Term
T/F Neglect syndrome is a behavioral disorder only.
Definition
False- neglect syndrome is an attentional disorder.
Term
in visual attention tests, brain activity shifts how?
Definition
retinotopically
Term
Your visual attention can be independent of your eye position T/F
Definition
True
Term
Which type of attention has more errors? Divided attention or selective attention?
Definition
Divided attention (aka. "multi-tasking")
Term
Areas of the brain responsible for detecting color and shape?
Definition
The V4, IT (occipital) and other visual areas in the temporal lobe
Term
Area(s) of the brain responsible for motion?
Definition
area MT (medial temporal) of the temporal lobe.
Term
inability to identify faces, facial blindness?
Definition
prosopagnosia
Term
A sudden car accident occurs outside of your visual field... are you more likely to turn your eyes toward the accident first, or shift your attention towards the accident before your eyes?
Definition
Your attention is likely to shift before your eyes saccade.
Term
WHO recorded neural activity at several locations in the brains of monkeys to determine whether there was increased activity that might be related to attention, before eye movements?
Definition
Michael Goldberg, David Robinson, and Robert Wurtz.
Term
WHO Record neural activity from several brain regions
Definition
Wurtz, Goldberg, and Robinson
Term
Which area of our brain tells our eyes to move towards where our attention is focusing?
Definition
parietal lobe
Term
T/F reaction time reduces in selective attention compared to divided attention.
Definition
True
Term
T/F reaction time increases in selective attention compared to divided attention.
Definition
FALSE
Term
Electrical stimulation to this area of the brain will result in saccades
Definition
the posterior parietal cortex
Term
T/F Divided attention has a quicker reaction time than selective attention.
Definition
FALSE
Term
What happens to attention when you are fatigued?
Definition
attention is unable to be maintained because attention requires energy.
Term
T/F- 1. Your eyes move before your attention.
Definition
FALSE- attention moves first
Term
T/F Invalid cue results in an increased reaction time.
Definition
True
Term
GABA agonists/antagonists are given to children with ADHD
Definition
agonists
Term
What structure is being studied for having a possible role in guiding attention?
Definition
the pulvinar nucleus of the thalamus (and FEF)
Term
Muscimol is a agonist/antagonist of GABA?
Definition
agonist, it suppresses activity of neurons on the contralateral side. Symptoms similar to a lesion to the pulvinar nucleus.
Term
Bicuculline is an agonist/antagonist of GABA?
Definition
Bicuculline is an antagonist of bicuculline, which facilitates shifting attention to the contralateral side.
Term
What drug has similar affects as a pulvinar nucleus lesion?
Definition
muscimol
Term
People with pulvinar nucleus lesions have what issue with attention?
Definition
They have difficulty switching attention to the contralateral side.
Term
part of the brain that directs eyes to objects of interest
Definition
superior colliculus
Term
What are FEFs?
Definition
Frontal eye fields. They are MOTOR fields that have direct connections with areas involved with attention, including V2, V3, V4, MT, and parietal cortex. involved in saccadic eye movements and may play a role in guiding attention.
Term
FEF stimulation significantly increases activity in what area of the brain?
Definition
V4
Term
Define Mental illness
Definition
Diagnosable disorder of thought, mood, or behavior that causes distress or impaired functioning
Term
T/F genetic and experiential variations, all ultimately expressed as physical changes in the brain, give rise to the full range of behaviors exhibited by the human population.
Definition
True
Term
What theory and who proposed it?
1) that much of mental life is unconscious
2) that past experiences, particularly in childhood, shape how a person feels and responds throughout life.
Definition
psychoanalysis by Sigmund Freud
Term
Who said that mental illness results when the unconscious and conscious elements of the psyche come into conflict?
Definition
Sigmund Freud
Term
What psychosocial theory believes in the active attempts to "unlearn" maladaptive behaviors to treat mental illness?
Definition
Behaviorism by B.F. Skinner
Term
Theory that focuses on observable behaviors and their control by the environment. behavior most likely with positive reinforcement.
Definition
Behaviorism (Skinner)
Term
The use of verbal communication to help the patient
Definition
psychotherapy
Term
What are the two mutually interacting factors impacting brain development?
Definition
nature (genes) and nurture (experience)
Term
reinforce behaviors by using punishment and rewards.
Definition
operant conditioning
Term
What resulted in 15% of ppl in mental institutions were CURED?
Definition
the discovery of penicillin in 1928... mental illness directly linked to a biological cause
Term
irrational fears=
Definition
phobias
Term
a treatment for agoraphobia.
Definition
systematic desensitization
Term
The inappropriate expression of fear characterizes ____, the most common type of psychiatric disorder.
Definition
anxiety disorders
Term
Define anxiety disorder
Definition
the inappropriate expression of fear.
Term
constant sympathetic state
Definition
generalized anxiety disorder
Term
Sudden feelings of intense terror that occur without warning.
Definition
panic attacks
Term
Anxiety about, or the avoidance of, places or situations from which escape might be difficult or embarrassing, or in which help may not be available in the event of a panic attack
Definition
agoraphobia
Term
obsessions, which case marked anxiety or distress, and/or compulsions, which serve to neutralize anxiety
Definition
obsessive-compulsive disorder
Term
clinically significant anxiety provoked by exposure to certain types of social or performance situations often leading to avoidance behavior
Definition
social phobia
Term
the re-experiencing of an extremely traumatic event, accompanied by symptoms of increased arousal and the avoidance of stimuli associated with trauma.
Definition
post-traumatic stress disorder
Term
long-term increase in cortisol results in damage to what important area?
Definition
hippocampus
Term
Your amygdala stimulates your HPA axis (stress response). Your hippocampus represses your HPA axis via feedback mechanism. Your amygdala stimulates the HPA axis via the bed nucleus neurons (connect senses to amygdala). Increased results in degeneration of your _____.
Definition
hippocampus
Term
what stimulates your HPA axis?
Definition
the amygdala (stress response)
Term
drug for anxiety disorders that binds to a GABA recetor site and acts to make GABA much more effective in opening th echannel and producing inhibition.
Definition
benzodiazepines
Term
What kind of medications break down GABA and thus stimulate the inhibitory affects of GABA to reduce anxiety?
Definition
anxiolytic medications (benzodiazepines & SSRIs)
Term
In low doses, this drug is highly affective in treating anxiety disorders, most noteably OCD, AND mood disorders.
Definition
SSRIs (serotonin-selective reuptake inhibitors)
Term
condition characterized by a feeling that one's emotional state is no longer under one's control.
Definition
depression
Term
minor depression, not long-lasting
Definition
dysthymia
Term
What happens in depression?
Definition
You have depression because of hypoactive reticular activating system.
Term
p. 669
Definition
Term
Type I or II bipolar disorder is always associated with episodes of major depression?
Definition
type II
Term
Hypothesis that states that mood is closely tied to levels of released "monamine" neurotransmitters- norepinephrine (NE) and/or serotonin (5-HT)
Definition
monamine hypothesis of mood disorders. depression is a deficit of one of these diffuse modulatory systems.
Term
drug that stops the degradation of noepinephrine and serotonin.
Definition
MAOIs (MAO inhibitors)
Term
The diathesis-stress hypothesis test
Definition
the HPA system is the main site where your genetic and environmental stressors converge to cause mood disorders.
Term
medical term for a predisposition for a certain disease is...
Definition
diathesis
Term
HPA axis stands for
Definition
hypothalamic-pituitary-adrenal
Term
name the major benefit and disadvantages of ECT treatment...
Definition
ECT can be affective when suicide risk is high; however, it results in memory loss. it usually disrupts memories for evetns that occurred before the treatment (retrograde)and temporarily affect new memories.
Term
removes the highs and lows of manic disorders by affecting the way secondary transporters work. but may cause tongue thrust
Definition
lithium
Term
characterized by a loss of contact with reality, and a disruption of thought, perception, mood, and movement.
Definition
schizophrenia
Term
hardest type of schizophrenia to treat...
Definition
disorganized schizophrenia
Term
positive symptoms of schizophrenia
Definition
-delusions
-hallucinations
-disorganized speech
-gross disorganized
Term
What is different between MRIs of individuals with schizophrenia versus those without?
Definition
schizophrenic brains have larger lateral ventricles, which shows a loss of brain tissue.
Term
Suspected and known brain changes in people with schizophrenia...
Definition
The ventricle to brain ratio is increased. The ventricles (CSF) occupy a bigger space in the brain than the cortex, less brain mass. Defects in myelin sheath in the axons of the cerebral cortex. Abnormal clusters of neurons in the cortex. Changes in synapses in different neurotransmitter systems.
Term
Dopamine hypothesis: Psychotic episodes in schizophrenia triggered by activation/deactivation of dopamine receptors
Definition
activation
Term
Glutamate hypothesis= how decreased/increased glutamate causes schizophrenia. Glutamate causes psychosis by aiding/inhibiting the NMDA receptors.
Definition
Glutamate hypothesis= how increased glutamate causes schizophrenia. Glutamate causes psychosis by inhibiting the NMDA receptors.
Term
characterized by involuntary movements of the lips and jaws
Definition
tardive dyskinesia
Term
Neuroleptic drugs bind to __ receptors and prevent decrease domamine and glutamate binding.
Definition
D2
Term
Can a CNS disorder be recovered from completely?
Definition
NO
Term
Can you recover completely from a median nerve injury?
Definition
yes
Term
In the inner part of the tube (neural stem), radial glia get created, which transport cells to the top layer.
Definition
vertical cleavage
Term
results when neurons begin to divide and multiply.
Definition
horizontal cleavage
Term
What kind of disorder happens if you don’t have pruning?
Definition
Autism
Term
Programmed Cell Death
Definition
apoptosis
Term
Monocular deprivation
Definition
your dominance changes to the eye that works best.
Term
Order the steps of neuronal structure development
-cell migration
-cell differentiation
-cell proliferation
Definition
-cell proliferation
-cell migration
-cell differentiation
Term
what is the fate of daughter cells after vertical cleavage?
Definition
both daughter cells remain in the ventricular zone to divide again and again
Term
What is the fate of daughter cells produced via horizontal cleavage?
Definition
The daughter cell furthest from the ventricular surface migrates away to take up tits position in the cortex, where it will never divide again. The other daughter remains in the ventricular zone to undergo more divisions.
Term
What are the three phases of development of long-range connections in the CNS?
Definition
1) pathway selection
2)target selection
3)address selection
Term
Growing tip of a neurite
Definition
growth cone
Term
protein molecules a part of extracellular matrix and whose interaction with each other promotes axonal elongation.
Definition
laminin and integrins
Term
holds axons together
Definition
cell-adhesion molecules (CAMS)
Term
finding the path of least resistance
Definition
stereogenesis
Term
is apoptosis or necrosis programmed cell death?
Definition
apoptosis
Term
Critical period for plasticity of binocular connections
Definition
4 weeks
Term
Who did rat mazes?
Definition
Lashley
Term
area of the brain that may encode memory of faces
Definition
IT
Term
Korascaff's syndrom
Definition
Alcoholics - thiamin deficiency
Symptoms: Confusion, confabulations, severe memory impairment, apathy, abnormal eye movements, loss of coordination, tremors
Lesions to dorsomedial thalamus and mamillary bodies
Term
Korascaff's syndrom
Definition
Alcoholics - thiamin deficiency
Symptoms: Confusion, confabulations, severe memory impairment, apathy, abnormal eye movements, loss of coordination, tremors
Lesions to dorsomedial thalamus and mamillary bodies
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