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Acquisition of new information or knowledge |
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Retention of learned information |
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Memory of facts and events – conscious access |
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Procedural memory (skills and habits), conditioning |
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declarative memory takes place where? |
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medial temporal lobe; decephalon |
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2 parts of nondeclarative memory |
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procedural memory; classical conditioning |
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procedural memory takes place where? |
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classical condition skeletal musculature takes place where? "" emotional responses where? |
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Permanent storage in long-term memory requires |
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Loss of memory and/or loss of the ability to learn |
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physical location of a memory |
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Experiments on cortical basis of learning by |
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Lashley found a correlation between the severity of behavioral deficit and size (but not location) of cortical lesions called |
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Conceptual link between memory storage and representation of stimuli within the cortex |
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reciprocally connected and distributed set of cells |
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Reverberation of activity within the assembly corresponds to |
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Persistence of activation leads to________of the assembly’s connections (“growth process”) |
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Subsequently, the assembly can be triggered by a weaker stimulus, or by only a portion of the stimulus. The reciprocal connection will automatically |
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“complete” the cortical representation of the stimulus. |
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Partial destruction of the assembly may not cause |
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Responses of neurons in inferior temporal cortex (IT) to faces show |
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learning-related changes over time |
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Responses of neurons in inferior temporal cortex (IT) to faces show learning-related changes over time. These neurons underlie both |
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Bilateral resection of the medial temporal lobe (1953) to ameliorate severe epileptic attacks, possibly due to a bicycle accident at age 9 (“a frankly experimental operation”) |
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memory appears to have a distinct neural substrate. Their work inspired animal models of amnesia |
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partial retrograde amnesia for events during the years preceding the operation, complete anterograde amnesia for all events following the operation |
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learn new tasks and skills |
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Structures in the medial temporal lobe are involved in the |
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consolidation of declarative memories |
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Delayed non-match to sample task |
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Delayed non-match to sample task (DNMS) probes |
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Lesions of the medial temporal lobes cause deficits in |
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Study of R.B. and other patients (G.D. etc.) showed that damage limited to (a specific subfield of) the hippocampal formation was sufficient to produce |
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clinically significant anterograde memory loss. |
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Other structures involved in declarative memory are located in the |
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Alcoholism (thiamine deficiency) results in damage to the mamillary bodies and |
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Medial temporal lobe areas are connected to the frontal lobes via the |
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dorsomedial nucleus of the thalamus. |
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Lesions of prefrontal cortex result in deficits of working memory used for |
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problem solving as well as planning of behaviors (recall Phineas Gage…) |
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Test for deficits often associated with prefrontal cortical damage... |
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Wisconsin card-sorting test |
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Working memory is often studied in |
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Neurons in monkey prefrontal cortex show |
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increased activity during a delay period (no stimulus present). |
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Neural activity corresponds to |
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mental representation of a “goal” |
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