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NeuroScience Chpt. 3
UMT Into Neuroscience
30
Medical
Undergraduate 3
09/20/2009

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Term
Action Potential
Definition
Nerve Impulse. Fixed Size and Duration.
Term
Excitable Membrane
Definition
Site of action potential. Present in cells capable of generating action potentials.
Term
Resting Membrane Potential
Definition
The difference in electrical charge across a membrane.
Term
Ion
Definition
Atoms/Molecules with a net electrical charge.
Term
Cation
Definition
Ion with a positive charge.
Term
Anion
Definition
Ion with a negative charge.
Term
Phospholipid bilayer
Definition
A stable arrangement of polar lipids isolating the cytosol from the extracellular fluid.
Term
Peptide bond
Definition
Bonds connecting Amino acids. Joins amino group of one to the carboxyl group of next.
Term
Polypeptides
Definition
Proteins made of a single chain of amino acids.
Term
Ion Channels
Definition
4-6 Similar protein molecules that form a pore across a membrane.
Term
Ion Selectivity
Definition
Property of ion channels. Specified by diamater of pore and R groups lining it.
Term
Gating
Definition
Ability for ion channels to be opened/closed by changes in the local microenvironment.
Term
Ion Pumps
Definition
Enzymes that utilize ATP to transport specific ions across the membrane.
Term
Diffusion
Definition
Movement of Ions from areas of high concentration to areas of low concentration.
Term
Concentration Gradient
Definition
A difference in concentration levels across a membrane.
Term
Electrical Current
Definition
Movement of electrical charge.
Term
Electrical Potential / Voltage
Definition
Force exerted on a charged particle.
Term
Electrical Conductance
Definition
Ability for charge to move from one point to another.
Term
Electrical Resistance
Definition
Relative inability for charge to migrate.
Term
Ohm's Law
Definition
I=gV
V = Potential
g = Conductance
I = Current
Term
Membrane Potential
Definition
Voltage across a membrane at rest.
Term
Microelectrode
Definition
Thin glass tube with a very fine tip. .5 um.
Term
Ionic Equilibrium Potential
Definition
Electrical potential difference that exactly balances the ionic concentration gradient.
Term
Ionic Driving Force
Definition
The difference between the real membrane potential and the equilibrium potential.
Term
Nernst Equation
Definition
Eion = 61.54/z mV log (Ion out/Ion in)
Term
Sodium/Potassium Pump
Definition
Uses ATP to maintain concentration gradient of Na/K.
Term
Calcium Pump
Definition
Enzyme that actively transports Ca out of cytosol. Uses ATP.
Term
Goldman Equation
Definition
Modified version of the nernst equation. Takes into account the relative permeability of all ions.
Term
Depolarization
Definition
Change in a membrane from its normal resting value (-65 mV) to a less negative value.
Term
Blood Brain Barrier
Definition
Specialization of brain capillaries that limits the movement of bloodborne substances into the extracellular fluid of the brain.
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