Term
| Describe the origin of biological amines |
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Definition
| Synthesized from Amino Acids |
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Term
| List 3 catecholamine biogenic amines, and give examples/locations of each of their respective neurons that release catecholamines |
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Definition
1. Dopamine: Midbrain neurons (including substantia nigra) 2. Epinephrine: "Adrenaline"; released by adrenal medulla (not a common neurotransmitter) 3. Norepinephrine: "Noradrenaline"; released by sympathetic postganglionic neurons and some CNS neurons. |
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Term
| How is the actions of catecholamines terminated? |
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Definition
| stopped by (1) uptake, and (2) enzyme degredation (MAO) |
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Term
| What types of drugs act on Dopaminergic synapses? |
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Definition
| Psychoactive drugs: amphetamines, cocaine, LSD |
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Term
| How is serotonin synthesized? How is it's action terminated? |
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Definition
Synthesized from tryptophan Stopped by re-uptake and MAO (enzyme) |
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Term
What mood-altering drugs act on Serotonin? Why is serotonin important? Where is serotonin found? |
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Definition
mood-altering drugs (diazapam; LSD; antidepressants) Important in pathways that control mood NT of many brainstem neurons which project to many areas of the CNS. |
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Term
Where is histamine found? What is it's function? |
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Definition
Released by some neurons in the hypothalamus Important nt in regulation of sleep and wakefulness |
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Term
What are the excitatory amino acid nt's? What are their effects when binding to their receptors? (channels involved) |
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Definition
glutamate and aspartate bind to NMDA receptors: Contain channels permeable to to Na+, K+ and Ca2+; Repeated activation is linked to Long Term Potentiation (LTP) - Can cause Excitotoxicity |
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