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Neuropharmacology
test
31
Other
Undergraduate 4
11/13/2007

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Term
PCPA
Definition
inhibits Tryptophan hydroxylase = decrease production of serotonin
Term
reserpine 
Definition
inhibits vesicular re-uptake of DA and 5-HT. however, effect reduced by l-dopa, but not 5-HTP
Term
para-chloroamphetamine  
Definition
releases 5-HT from nerve terminals
Term
fenfleuramine  
Definition
releases 5-HT from nerve terminals
Term
MDMA
Definition
releases 5-HT from nerve terminals
Term
fluoxitine  
Definition
inhibitis 5-HTP reuptake (= prozac)
Term
buspirone, isapirone
Definition
5HT1A agonists
Term
WAY 100635
Definition
5HT1A antagonists
Term
DOI  
Definition
5HT2A agonists
Term
ketanserin, ritanserin
Definition
5HT2a antagonists
Term
5, 7 DHT  
Definition
destroys serotonergic neurons
Term
NBQX
Definition
AMPA and Kainate receptor (ionotropic glutamate) antagonist. = decrease motor activity, ataxia, inhibits electrically induced seizures
Term
memantine 
Definition
low affinity ionotropic glutamate receptor antagonist used to treat alzheimers
Term
GAD blockers
Definition
allylglycine, thiosemicarbazide (ties up B6), 3 mercaptoproprionic acid
Term
tigabine
Definition
inhibits GAT-1 which removes GABA. used to treat partial seizures
Term
vigabatrin
Definition
inhibits GABA-T which breaks GABA down to succinate. also used to treat seizures
Term
muscimol  
Definition
GABAa agonist (ionotropic GABA receptor)
Term
bicuculline 
Definition
competitive GABAa receptor antagonist (ionotropic)
Term
picrotoxin  
Definition
non-competitive GABA A receptor (ionotropic) antagonist
Term
baclofen
Definition
GABA b (metabotropic) receptor agonist
Term
phaclofen
Definition
GABA b receptor antagonist
Term
disulfiram  
Definition
inhibits aldehyde dehydrogenase. used in alcoholism treatment because acetylaldehyde builds up and it is toxic
Term
buprenorphine
Definition
partial opiate receptor agonist
Term
mecamylamine
Definition
blocks post ganglionic nicotinic receptors
Term
methoxsalen
Definition
inhibits liver nicotine metabolism
Term
buproprion
Definition
inhibits DA reuptake (also 5-HT and NE) used to help stop nicotine use, also used as anti-depressant
Term
endogenous cannabinoids
Definition

related to arachidoic acid

andandamide

2-arichidonoylglycerol 

Term
marinol  
Definition
appetite stimulant - cannabinoid based mediaction, aslo anti-emetic and anti-nausea drug for chemo pts
Term
nabilone
Definition
cannabis based anti-emetic and anti-nausea drug for chemo pts
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