Formed by oligodendrocytes

Contains PLP, MBP, and MAG 

Formed by Schwann cells

Contain MGP, protein P0, and NO PLP 

Demyelination Consequences

(4) 

1. Conduction delay or block

2. Prolonged refractory period

(Lead to negatie symptoms)

3. Hyperexcitability

4. Spontaneous depolarization and ephaptic transmission

( Lead to positive paroxysmal symptoms)

Plaque in the brain due to demyelination of axons in MS

Also see astrocytosis 

Acute MS

Stain for myelin

Dark blue spots are myelin within macrophages

Severe inflammation and cell trafficking