Term
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Definition
- MOA: strong mu R agonist, inhib adenylate cyclase-> decr substance P, GABA, DA, NE
- USE: decrease perception of pain, diarrhea, anesthesia adjunct
- PHARM: high plasma prot binding, rapid abs, metab by conjugation to glucoronidate in liver
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Term
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Definition
- MOA: strong mu R agonist
- USE:analgesi(decr perception of pain), diarrhea, shivering
- TOX: demethylated metabolites can accum in liver-->seizure
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Term
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Definition
- MOA: mild-mod mu R agonist, decr cAMP by inhib aden cycl-->decr release of DA, ACh, GABA, substance P, NE
- USE: analgesic
- TOX: constipation, NV
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Term
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Definition
- MOA: Strong mu R agonist
- PHARM: long lasting, slow acting
- USE: alcohol withdrawal
- TOX: constipation, NV, resp depression
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Term
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Definition
- MOA: strong mu R agonist; decr Ach, NE, DA, GABA
- USE: analgesic
- TOX: often abused because difficult to pick up in blood,
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Term
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Definition
- MOA: mild-mod mu R agonist
- USE: analgesic, diarrhea
- TOX: constipation, NV, resp depression
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Term
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Definition
- MOA: mixed agonist-antagonist at opiate Rs
- PHARM: 1/6-1/3 as potent as morphine
- USE: mod to severe pain
- TOX: less activity at mu-->less resp depression and dependence, incr BP and HR
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Term
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Definition
- MOA: opiate R antagonist, competitively block mu, kappa and delta R
- USE:
- TOX: no resp depression
- PHARM: significant first pass metab so can't be given orally
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