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Neurology: Multiple Sclerosis
Pathophysiology 2
14
Health Care
Graduate
11/17/2009

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Cards

Term
Type of disease
Definition
Central Nervous System Autoimmune Disease
Term
Multiple Sclerosis Type of disease
Definition
Central Nervous System Disease
Term
Epidemiology
Definition
Young white females 15-55. Increases further from the equator. Possibly related to weather and particular virus or genetic pool.
Term
Pathophys
Definition
Attacks myelin sheaths of CNS. Many scars form multiple areas of demyelination. In white matter where axon nerve tracts are.
Term
Causes
Definition
Theory: molecular mimicry: Myelin sheaths molecularly resemble something hostile immune system has attacked before: virus, food etc.Immune system attack it.
Term
TX, general
Definition
More aggressive now to prevent destruction of axon.
Term
TX: Drugs
Definition
ABC:
Interferon beta 1 A: to modulate immune system.
Interferon beta 1 B
Copaxone: a peptide that resembles myeline sheath structure as a decoy.
Term
TX: Non drug
Definition
Vitamin B 400 iu daily to increase muscle strength, prevent falls.
FLu vaccinations
Stay cool
Term
3 Diagnostic criteria
Definition
1. Age, gender profile
2. Multiple CNS lesions (multifocal white matter disease)
3. Waxes and wanes
Term
Common triggers
Definition
Heat, infection, physical, mental stress
Term
Patient may have
Definition
Heat intolerance
Babinsky reflex: Stroke side, bottom of foot- toes will flare up
Multi Internuclear Opthalmoplegia: Highly signifies MS. As turn eyes to side, far eye has problem turning, near eye jerks
Term
Most common pattern
Definition
Relapsing, remitting course, waxes and wanes. After some years, doesn't wax and wane. Most problems have problems walking by 20 years.
Term
Common neurological deficits
Definition
Visual, fatigue, sensory deficit, some cognitive deficit, pain, clinical depression
Term
Symptoms
Definition
Stumbling gait, tendency to fall, visual acuity
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