Term
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Definition
- prevents release of Ca from SR - malignant hyperthermia and neuroleptic malignant syndrome |
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Term
agonize dopamine receptors |
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Definition
bromocriptine, pramipexole, ropinrole |
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Term
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Definition
amantadine, L-dpa/carbidopa |
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Term
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Definition
selsgiline, entacapone, tolcapone |
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Term
curb excess cholinergic activity |
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Definition
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Term
parkinsons' tx strategies |
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Definition
inc DA, agonize DA receptors, prevent DA breakdown, curb excess cholinergic activity |
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Term
L-dopa/carbidopa toxicity |
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Definition
dyskinesia with administration and akinesia between doses |
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Term
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Definition
inhibits MOAb with metabolizes DA over NE and 5HT |
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Term
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Definition
reserpine + tetrabenazine = amine depleting haloperidol = DA antag |
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Term
alpha agonists for glaucoma |
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Definition
epinephrine = dec aqueous humor synthesis due to vasoconstriction brimonidine = dec aqueous humor synthesis |
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Term
beta blockers for glaucoma |
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Definition
timolol, betaxolol, carteolol= dec aqueous humor secretion |
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Term
|
Definition
acetazolamide or mannitol = dec aqueous humor secretion due to dec HCO3- |
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|
Term
cholinomimetics for glaucoma |
|
Definition
direct = pilocarpine, carbachol indirect = physostigmine, echothiphate - inc outflow of aqueous humor |
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Term
prostaglandin for glaucoma |
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Definition
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|
Term
|
Definition
mu = morphine, delta= enkephalin, kappa = dynorphin |
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Term
|
Definition
open K channels, close Ca channels |
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|
Term
opioid for cough suppression |
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Definition
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Term
|
Definition
loperamide and diphenoxylate |
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Term
|
Definition
respiratory depression, pinpoint pupils, CNA depression |
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Term
|
Definition
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Term
|
Definition
partial agonist at mu receptors; agonist at kappa |
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|
Term
butorphanol - use - toxicity |
|
Definition
- pain; less reap depression - withdrawal if on full agonist |
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|
Term
tramadol - MOA - use - toxicity |
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Definition
- weak opioid agonist, inhibits serotonin and NE reuptake - chronic pain - decreases seizure threshold |
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|
Term
1st line for status epileptics prophylaxis |
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Definition
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|
Term
1st line for absence seizures |
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Definition
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|
Term
1st line for acute status epilepticus |
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Definition
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|
Term
seizure drugs that inc GABA |
|
Definition
gabapentin, topiramate, phenobarbital, valproate, benzo, tiagabine, vigabatrin, levetiracetam |
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|
Term
1st line for trigeminal neuralgia |
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Definition
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|
Term
seizure drug also used for peripheral neuropathy and bipolar |
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Definition
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|
Term
1st line in pregnant women and children seizure drug |
|
Definition
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|
Term
used for sieuzres or eclampsia |
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Definition
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|
Term
also used for myoclonic seizures |
|
Definition
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|
Term
seizure drugs that block Na |
|
Definition
phenytoin, carbamazepine, lamotrigine, topiramate, valproate |
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Term
|
Definition
thalamic T-type Ca channels |
|
|
Term
SE: agranuloctosis, aplastic anemia |
|
Definition
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|
Term
seizure drug that induces CYP450 |
|
Definition
carbamazepine, phenobarbital |
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|
Term
Se: stevens-johnson syndrome |
|
Definition
carbamazepine, ethosuximide, lamotrigine |
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
phenytoin - use - toxicities |
|
Definition
- tonic-clonic seizues - SLE-like, gingival hyperplasia, peripheral neuropathy, megaloblastic anemia, fetal hydantoin syndrome |
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|
Term
barbiturate - use - toxicity |
|
Definition
- sedative for anxiety, induction of anesthesia - additive CNS depression, respiratory or cardiovascular depression, induction of p450 |
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Term
|
Definition
- anxiety, spasticity, status epileptics, night terrors, sleepwalking, general anesthetic, hypnotic - dependence, additive CNS depression, less risk of reps depression |
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|
Term
|
Definition
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Term
|
Definition
zolpidem, zaleplon, eszopiclone |
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|
Term
nonbenzo hypnotics - use - toxicity |
|
Definition
- insomnia - ataxia, HA, confusion, short duration, lower dependencee risk |
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|
Term
anesthetic properties for - rapid induction - high potency |
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Definition
- dec solubility in blood - inc solubility in lipids |
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|
Term
has low blood and lipid solubility |
|
Definition
N2O = fast induction and low potency |
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|
Term
ex has high lipid and blood solubility |
|
Definition
halothane = high potency and slow induction |
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|
Term
anesthetic MOA in - lungs - blood - tisue |
|
Definition
- inc rate + depth of ventilation = inc gas tension - inc blood solubility = inc blood/gas partition coefficient = inc solubility = inc gas required to saturate blood = slower onset of action - AV concentration gradient inc = inc solubility = inc gas to saturate tissue = slower onset of action |
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|
Term
anesthetic for induction of anesthesia |
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Definition
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|
Term
inhaled anesthetic: hepatotoxicity |
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Definition
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|
Term
inhaled anesthetic: nephrotoxicity |
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Definition
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|
Term
inhaled anesthetic: proconvulsant |
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Definition
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|
Term
inhaled anesthetic: malignant hyperthermia |
|
Definition
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|
Term
inhaled anesthetic: expansion of trapped gas |
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Definition
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|
Term
|
Definition
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|
Term
may cause severe post op respiratory depression |
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Definition
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|
Term
|
Definition
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|
Term
SE: hallucinations, disorientation, bad dreams |
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Definition
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|
Term
anesthesia for brain surgery |
|
Definition
thiopental because dec cerebral blood flow |
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|
Term
opiate that does not cause histamine release |
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Definition
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|
Term
rapid induction of short procedures |
|
Definition
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|
Term
high triglyceride count can lead to pancreatitis |
|
Definition
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|
Term
local anesthetics esters vs. amides |
|
Definition
esters = one "I" amides = two "I"s |
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|
Term
order of nerve blockade with local anesthetics |
|
Definition
small myelinated > small unmyelinated > large myelinated > large unmyelinated |
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|
Term
order of sensory loss for local anesthetics |
|
Definition
pain > temp > touch > pressure |
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|
Term
toxicity of local anesthetics |
|
Definition
severe cardiovascular toxicity = bupivacain, CNS excitation, HTN, hypotention, and arrhythmias |
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Term
|
Definition
succinylcholine phase I = depolarization, no antidote, inc by cholinesterase inhibitor phase II = repolarization, antidote of cholinesterase inhibitor |
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Term
|
Definition
compete with ACh for receptors; reversal with AChE inhibitors |
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