Term
1st line prophylaxis for status epilepticus |
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Definition
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Term
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Definition
increases the sodium channel inactivation |
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Term
Type of epilepsy that Phenytoin treats |
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Definition
simple, complex and tonic-clonic |
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Term
What does carbamazepine treat? |
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Definition
It is first line treatment for:
Simple
Complex
Tonic-Clonic |
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Term
1st line treatment for trigeminal neuralgia |
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Definition
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Term
Mechanism of action of lamotrigine |
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Definition
blocks voltage-gated sodium channels |
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Term
What does lamotrigine treat? |
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Definition
Epilepsy
simple, complex and tonic-clonic |
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Term
What does gabapentin treat? |
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Definition
epilepsy
simple, complex, tonic-clonic |
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Term
Mechanism of action of gabapentin |
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Definition
designed as a GABA analog but primarily inhibits high-voltage-activated Ca2+ channels |
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Term
List some other things gabapentin can treat |
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Definition
Peripheral neuropathy, postherpetic neuralgia, migraine prophylaxis, bipolar disorder |
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Term
What type of epilepsy does topiramate treat? |
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Definition
simple, complex and tonic-clonic |
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Term
Mechanism of action of topiramate |
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Definition
blocks sodium channels and increases GABA action |
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Term
Aside from epilepsy what else can topiramate treat? |
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Definition
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Term
1st line treatment for epilepsy in children |
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Definition
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Term
Mechanism of action of phenobarbital |
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Definition
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Term
Type of epilepsy that phenobarbital treats |
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Definition
simple, complex, tonic-clonic |
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Term
What is valproic acid first line treatment for? |
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Definition
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Term
Mechanism of action of valproic acid? |
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Definition
increase sodium channel inactivation, increase GABA concentration |
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Term
What can treat myoclonic seizures? |
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Definition
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Term
What does ethosuximide treat? |
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Definition
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Term
Mechanism of action of ethosuximide |
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Definition
Blocks thalamic T-type Ca2+ channels |
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Term
1st line treatment for acute status epilepticus |
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Definition
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Term
Mechanism of action of benzodiazepines |
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Definition
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Term
List 2 meds that can treat seizures of eclampsia |
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Definition
benzodiazepines
1st line treatment is MgSO4 |
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Term
Mechanism of action of Tiagabine |
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Definition
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Term
Mechanism of action of Vigabatin |
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Definition
irreversibly inhibits GABA transaminase-> increase GABA |
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Term
Toxicity of Benzodiazepines |
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Definition
sedation, tolerance dependence
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Term
what is steven-johnson syndrome? |
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Definition
prodrome of malaise and fever followed by rapid onset of erythmatous/purpuric macules. Skin lesions progress to epidermal necrosis and sloughing |
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Term
Toxicities of carbamazepines? |
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Definition
diplopia, ataxia, blood dyscrasias(agranulocytosis, aplastic anemia), liver toxicity, teratogenesis, induction of p450, SIADH, steven-johnson syndrome |
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Term
Toxicities of ethosuximide |
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Definition
GI distress, fatigue, headache, urticaria, steven-johnson syndrome
EFGH- Ethosuximide, fatigue, GI headache
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Term
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Definition
sedation, tolerance, dependence, induction of p450 |
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Term
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Definition
nystagmus, diplopia, ataxia, sedation, gingival hyperplasia, hirsutism, megaloblastic anemia, teratogenesis, SLE-like syndrome, induction of cytochrome p450, lymphadenopathy, steven-johnson syndrome, osteopenia |
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Term
Toxicities of Valproic acid |
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Definition
GI distress, rare but fatal hepatotoxicity, neural tube defects in fetus, tremor, weight gain |
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Term
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Definition
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Term
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Definition
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Term
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Definition
sedation mental dulling, kidney stones, weight loss |
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Term
What can treat insomnia? (3) |
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Definition
nonbenzodiazepines:
zolpidem
zaleplon
eszopiclone |
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Term
Mechanism of nonbenzodiazepines |
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Definition
act via BZ1 subtype of the GABA receptor. Effects reversed by flumazenil |
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Term
Effects of inhaled anesthetics |
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Definition
myocardial depression, respiratory depression, nausea/emesis, increased cerebral blood flow |
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Term
Toxicity of inhaled anesthetics |
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Definition
hepatotoxicity(halothane), nephrotoxicity (methoxyflurane), proconvulsant (enflurane), malignant hyperthermia (all but nitrous oxide), expansion of trapped gas in a body cavity (nitrous oxide) |
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Term
What are some IV anesthetics? |
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Definition
B. B. King on OPOIDS PROPOses FOOLishly
barbituates
benzodiazepines
ketamine
opiods
propofol |
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Term
Mechanism of action of dantrolene |
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Definition
prevents release of Ca2+ from the sarcoplasmic reticulum of skeletal muscle |
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Term
What treats malignant hypothermia? |
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Definition
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Term
What drugs treat parkinsons? Mechanism of action |
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Definition
Bromocriptine- dopamine agonist
Amantadine- increase dopmine
Levodopa(with carbidopa)- converted to dopamine in CNS
Selegiline (and COMT inhibitors)- prevents dopamine breakdown
Antimuscarinics- curb excess cholinergics to improve tremor and rigidity |
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Term
Mechanism of action of selegiline |
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Definition
selectively inhibits MAO-B so it doesn't metabolize dopamine |
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Term
Memantine mechanism of action |
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Definition
Treats alzheimers
NMDA receptor antagonist; helps prevent excitotoxicity |
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Term
Mechanism of action of donepezil, galantamine and rivastigmine |
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Definition
acetylcholinesterase inhibitor |
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Term
What are some neuro changes you'll see in huntington's? |
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Definition
decrease in GABA decrease in ACh
increase in dopamine |
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Term
Tetrabenazine and reserpine mechanism of action |
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Definition
Treat Huntington's Disease
inhibits VMAT; limits dopamine vesicle packaging and release |
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Term
Mechanism of action of haloperidol |
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Definition
Treats Huntington's Disease
dopamine receptor antagonist |
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Term
Disease associated with arbovirus |
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Definition
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Term
Disease associated with coxsackievirus |
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Definition
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Term
Disease associated with CMV |
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Definition
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Term
Disease associated with HSV 1 |
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Definition
Meningitis and encephalitis |
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Term
Disease associated with HIV |
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Definition
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Term
Disease associated with lymphocytic choriomeningitis |
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Definition
meningitis and encephalitis |
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Term
Disease associated with poliovirus |
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Definition
encephalitis and myelitis-spinal cord |
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Term
Disease associated with rabies virus |
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Definition
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Term
Most common cause of neonatal meningitis |
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Definition
Group B streptococcus (gram + coccus) |
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Term
2nd most common cause of neonatal meningitis |
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Definition
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Term
Most common cause of meningitis between 1 month and 18 years of age |
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Definition
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Term
Most common cause of meningitis in patients over 18 years of age |
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Definition
stept. pneumoniae (gram + diplococcus) |
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Term
Most common fungal CNS infection in AIDS |
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Definition
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Term
What fungus occurs in diabetic ketoacidosis and causes a frontal lobe abscess |
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Definition
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