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Neuroanatomy Lecture 9
South College
50
Other
Graduate
12/07/2008

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Term
Cervical plexus formed by:
Definition
Ventral rami C1-C4
Term
Most branches are:
Definition
Cutaneous nerves of neck, ear, back of head, and shoulders
Term
Most important nerve of cervical plexus
Definition
Phrenic
Term
Brachial plexus formed by:
Definition

C5-T1

(C4 and T2 may also contribute)

Term
Brachial plexus gives rise to:
Definition
Nerves that innervate the upper limb
Term
4 major branches of brachial plexus
Definition

Roots (5 ventral rami)

Trunks (upper, middle, lower)

Divisions (anterior and posterior)

Cords (lateral, medial, and posterior)

Term
Terminal nerves of brachial plexus
Definition
Axillary = deltoids + teres minor
Musculoskeletal = biceps brachii + brachioradialis
Median = flexor muscles of arm
Ulnar = FCU + part of FDP
Radial = mostly all extensors
Term
C2
Definition
Sensory and motor = head and neck
Term
C4
Definition

Sensory = shoulders

Motor = diaphragm

Term
C5
Definition
Sensory = lateral (outer) upper arm
Motor = deltoid + biceps
Reflex = biceps
Term
C6
Definition

Sensory = lateral (outer) forearm + thumb + index finger

Motor = wrist extension + bicep

Reflex = brachioradialis (forearm tendon)

Term
C7
Definition

Sensory = middle finger

Motor = wrist flexion + finger extension

Reflex = triceps

Term
C8
Definition
Sensory = medial forearm + ring + little finger
Motor = finger flexion
Term
T1
Definition
Sensory = medial (inner) upper arm
Motor = interossei (finger abduction and adduction)
Term
T2-T12 Sensory
Definition

T4 = nipple line

T7 = xiphoid process

T10/11 = umbilicus

T12 = pubic bone

Term
T2-T12 Motor
Definition

T2-T4 = intercostals

T5-T12 = rectus abdominis

T12 = iliopsoas

Term
Lumbar plexus arises from
Definition
L1-L4
Term
Lumbar plexus innervates
Definition

Abdominal wall

Thigh

Psoas muscle

Term
Major nerves of lumbar plexus
Definition

Femoral

Obturator

Term
L1-L3 sensory
Definition

L1 = upper thigh

L2 = mid-thigh

L3 = lower thigh

Term
L1-L3 motor
Definition
Quadriceps
Term
Spinal cord ends:
Definition
Between L1 and L2
Term

L4

Definition
Sensory = medial foot and medial lower leg
Motor = foot inversion (tibialis anterior)
Reflex = patellar tendon
Term
L5
Definition
Sensory = lateral lower leg + dorsal foot
Motor = toe extensors (EDL)
Term
Sacral plexus arises from _______ and serves ________________
Definition

L4-S4

Lower limb, pelvic structures, perineum 

Term
Major nerve of sacral plexus
Definition
Sciatic (longest and thickest nerve in body and is actually composed of 2 nerves- the tibial and common fibular/peroneal)
Term
S1
Definition

Sensory = lateral foot

Motor = foot eversion (peroneals)

Reflex = Achilles tendon

Term
S2-S4
Definition

Sensory = 3 concentric rings around anus and genital regions

Motor = Bladder, bowel, sex organs, anal and pelvic muscles

Reflex = anal sphincter contraction 

Term
Types of Nerve Disorders
Definition

Focal

Multifocal (mononeuropathy multiplex)

Generalized polyneuropathy (aka peripheral neuropathy)

Term
Focal nerve d/o
Definition

Diabetic mononeuropathy (e.g. 6th or 3rd nerve)

Compressive (e.g. CTS)

Term
2 main types of generalized polyneuropathy
Definition

Axon-losing (diabetic peripheral neuropathy)

Demyelinating (AIDP/Guillian Barre)

Term
Diabetic neuropathy
Definition

Sensory loss

-Distal (stocking-glove pattern)

-Symmetrical

 

Cause = multiple mechanisms (including compromise of microvascular blood supply of the peripheral nerves)

    

Term

Acute Inflammatory Demyelinating Neuropathy = AIDP

(Guillian Barre Syndrome)

 

Cause

Onset

Definition
Cause = immune-mediated demyelination of peripheral nerves
 
Onset = typically 2 weeks after a viral infection
 
 
Term

AIDP

Clinical Presentation

Definition

Progressive weakness

Areflexia

Paresthesias

Elevated CSF protein

Nerve conductions show demyelination

Peaks at 3 weeks

Recover over many months

Term
Impaired neuromuscular junction
Definition

-Generalized symmetrical motor weakness

-Weakness worsens throughout day (i.e., with
  repeated use of the muscle

-Normal reflexes

-No sensory deficits

 

*Chronic condition*

Term
Representative case of impaired neuromuscular junction
Definition

Myasthenia Gravis

 

Antibodies against polysynaptic Ach receptors in the neuromuscular junction

Diagnosis = blood test (anti-Ach receptor antibodies)

Thymomas in 12% - do imaging

Treatment = pyridostigmine- cholinesterase inhibitor (Mestinon) and plasma exchange and azathioprine (Imuran)

Term
Muscle disease =
Definition

Myopathy

 

Greater weakness proximally

Normal sensation

Normal reflexes

CPK elevated

EMG - myopathic potentials

Term
Some causes of myopathy
Definition
DMD = most common form
    -X-linked recessive (affects mostly males)
    -Dystrophin (protein) is absent
 
Polymyositis
Term
Causes of back pain
Definition
LOTS!!
Main one = mechanical - disk herniation
Term
Radiculopathy
Definition

Burning pain that radiates into the affected dermatome

Loss of reflexes

Weakness in myotome

 Positive SLR

 

Common = L5, S1 >> C6, C7

Term
T1 radiculopathy →
Definition

Horner's syndrome

(via sympathetic path to face/eye)

Term
Causes of radiculopathy
Definition

Disc herniation

Osteophytes

Spinal stenosis

Trauma

Term
Pancoast's Syndrome
Definition

Horner's Syndrome

Ulnar nerve problem

Lung tumor (C8-T1 can be impinged by mass in lung
                  where it crosses over apex)

Term
Ulnar Nerve Palsy
Definition
Numbess in 1/2 of ring+ little finger
Term
Loss of radial nerve
Definition
Wrist drop
Snuff box area will be numb
 
Saturday night palsy- fall asleep in position where something is compressing nerve in groove (lower armpit area)
Term
CTS
Definition
Almost purely sensory- fingers tingle (except 1/2 ring finger + all of little finger)
Common to be bilateral
Worse when laying down (c/o waking up with increased symptoms at night)
Term
The other scapular winging
Definition

Accessory nerve to trapezius muscle (which helps to fixate the scapula)

Worse with ABD (NOT with pushing)

Winging dissapears with flexion of arm

Term
Meralgia Paresthetica
Definition

Femoral nerve injury

 

Term
Nerve conduction studies
Definition

Diminished amplitude implies axon loss

Reduced velocity implies demyelination

Term
Electromyogram (needle exam)
Definition

Fibrillation in a resting muscle potential implies active demyelination of  muscle

Polyphsaic motor unit potentials during contraction implies chronic denervation of muscle

Low voltage motor unit potentials during contraction implies myopathy

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