Term
| What happens to AChe after binding to the cholinergic receptor (nicotinic) at the neuromuscular junction? |
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Definition
-It is degraded by AChE and sent back to the presynaptic neuron as choline
-There, Ch is reacted with **Acetyl CoA using **choline acetyltransferase to produce ACh one again
-This is then reloaded into vesicles |
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Term
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Definition
-Endplate potential, may also be written MEPP
(just for reference) |
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Term
| Are there voltage gated Na+ channels at the endplate? |
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Definition
| -No, only metabotropic (nicotinic ones) |
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Term
| What degrades NE and where do we find it? |
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Definition
-For adrenergic receptors, norepinephrine is used (NE)
-Instead of being degraded outside the neuron, it is taken back up by it via active transport, and degraded by **MAO |
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Term
| What kinds of cholinergic receptors are there on effector organs for autonomics? |
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Definition
-All muscarinic
-Sympathetic use mainly NE, and ACh for sweat glands
-*Para use all ACh, though |
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