Term
| What is the mechanism and adverse effects of phenytoin? |
|
Definition
Voltage-Dep Na Block
Adverse: Zero-Order Kinetics and
P450 inducer |
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|
Term
| What is fosphenytoin and what are the advantages |
|
Definition
Phosphate ester prodrug of Phenytoin
Adv: Improves solubility
Less venous irritation |
|
|
Term
| What is the mechanism of primidone |
|
Definition
| Metabolized to phenobarbital and phenylethylmalonamide |
|
|
Term
| What is the mechanism and use of Ethosuxomide |
|
Definition
Inhibit t-type Ca channels in Thalamus
Use: only in absence generalized seizures |
|
|
Term
| How long does it take to reach steady state with primodine |
|
Definition
|
|
Term
| What are the adverse effects of phenobarbital and primidone |
|
Definition
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|
Term
| What is oxcarbamezine and how does it compare to carbamezipine |
|
Definition
Prodrug: active metabolite is 10,11dihydro-10-hydroxycarbazepine, No epoxide metabolite
More hypernatremia
|
|
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Term
| Mechanism of Valproate and adverse effcects |
|
Definition
MOA: Voltage-Dep Na
T-type Ca block
Enhance GABA
Argument K
Adverse: Hepatoxic(more common in Combos)
Teratogenic(neural tube defects)
Ataxia
Weight Gain
Platelet Decrease |
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|
Term
| What is the mechanism and adverse effects of Vigabatrin |
|
Definition
Blocks GABA degradation
Adverse: Visual field constriction
Psycosis/Behavioral
Myelinic Edema in infants
P450 inhibition |
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|
Term
|
Definition
|
|
Term
| What is the mechanism topiramate |
|
Definition
Voltage-Dep Na block
Gaba potentiation
AMPA(Kainate) Antagonism |
|
|
Term
| What are the adverse effects of lamotrigene |
|
Definition
Stephen-Johnson in Children and Rapid Increase
Decreased half-life with Carbamezipine, Phenytoin, Phenobarbital, Primidone
Increased Half-life with Valproate |
|
|
Term
| Zonisamide mechanism and adverse effects |
|
Definition
Voltage-Dep Na
Block Ca
Pathological Glutamine
Adverse: Renal Stones |
|
|
Term
| What is the mechanism of Felbamate and its adverse effects? |
|
Definition
Voltage Dep Na
Gaba Potentiation
Block NMDA
Adverse: Aplastic Anemia
Hepatotoxicity |
|
|
Term
| What are the advantages and uses of gabapentin |
|
Definition
Advantages: No metabolism, Low toxicity
Generalized Adjuctive therapy |
|
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Term
| What are the mechanisms and uses of Pregabalin, Leviteracetam, Lacosamide, Rufinamide |
|
Definition
Pregabalin: Alpha2 Delta of Ca channel
use-Partial seizures
Lacosamide: Collapsin Response Mediator Protein 2 binding
use- Partial
Leviteracetam: Synaptic vesical protein(SV2) binding
use-Partial/Generalized
Rufinamide: Unknown
use-Lennox-Gastaut Syndrome |
|
|
Term
| What is the mechanism of Regitabine |
|
Definition
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