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Neuro physiology - Guyton & Hall
Unit IX
42
Physiology
Graduate
07/28/2011

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Term
Meissner's Corpuscle
Definition
An elongated, encapsulated receptor found in the dermal pegs of blabrous skin, especially abundant on the lips & finger tips.
Term
Merkel's Disc
Definition
An expanded tip tactile receptor found in the dermis of hairy skin that is specialized to detect continuously applied touch sensation
Term
Free Nerve Endings
Definition
A non-encapsulated receptor found in the epidermis of the skin throughout the body as well as in the cornea, where it signals touch, pressure and pain sensations
Term
Pacinian Corpuscle
Definition
An encapsulated receptor found deep in the skin throughout the body as well as in facial layers, where it detects indentation of the skin (pressure) and movement across the surface (vibration)
Term
Labeled Line Principle
Definition
The concept of specificity in sensory nerve fibers that transmit only one modality of sensation.
Term
Prostaglandins
Definition
This substance enhances the sensitivity of pain receptors but does not directly excite them.
Term
Free Nerve Endings
Definition
Pain receptors in the skin are classified as this
Term
True
Definition
True or False: An important functional parameter of Pain receptors is that they exhibit little or no adaptation.
Term
About 0.1 seconds
Definition
After a pain stimulus is applied, how long does it take for fast pain to be felt?
Term
Type Aδ (delta) fibers, NOT Type C fibers.
Definition
Which pain fibers are responsible for the localization of a pain stimulus?
Term
Glutamate
Definition
Which transmitter agent is used by the fast pain fibers at their synapses in the dorsal horn?
Term
Activation of cAMP or cGMP
Definition
In chemical synapses that involve a so-calledd 2nd messenger, typically a G-protein linked to the post-synapic receptor is activated when the neurotransmitter binds to that receptor. What is an activity performed by the activated 2nd messenger?
Term
Substance P
Definition
A transmitter agent used by the slow pain fibers that is released slowly over a period of seconds or minutes at synapses in the dorsal horn.
Term
Dorsal colum-medial lemniscal system
Definition
This system conveys information concerning highly localized touch sensations and body position (proprioceptive) sensations.
Term
Dorsal Root Ganglia
Definition
Where are first-order (primary afferent)neuronal cell bodies of the dorsal column-medial lemniscal system found?
Term
Medial Lemniscus
Definition
Which structure carries axons from the nucleus gracilis to the thalmus?
Term
The Internal Capsule
Definition
This structure carries axons from neurons in the ventral posterolateral nucleus of the thalmus to the primary somatosensory cortex.
Term
The Periaqueductal Gray
Definition
This group of neurons in the brain's endogenous pain suppression system has cell bodies located in a portion of the midbrain.
Term
The Lower Limb
Definition
Which body parts is represented superiorly and medially within the postcentral gyrus?
Term
Nucleus Raphes Magnus
Definition
Which region of the pain supression pathway do neurons use serotonin as a neurtransmitter?
Term
It Increases
Definition
As the receptor potential rises higher above a threshold, what happens to the new frequency of action potentials?
Term
Dorsal Horn of the spinal cord
Definition
An interneuron in this region uses enkephalin to inhibit pain transmission.
Term
3,1,2
Definition
What is the Brodmann number designation for the primary somatosensory cortex?
Term
Type Aβ (beta) fibers in peripheral nerves
Definition
Inhibition of pain signals by tactile stimulation of a skin surface involves which type of pain fibers?
Term
True
Definition
True or False: The size of the representaion of various body parts in the primary somatosensory cortex is correlated with the density of specialized peripheral receptors (aka cutaneous receptors) in that body part.
Term
Layer IV
Definition
The gray matter of the primary somatosensory cortex contains six layers of cells. Which layer receives the bulk of incoming signals from the somatosensory nuclei of the thalmus?
Term
True
Definition
True or False: Visceral pain fibers can provide input to anterolateral tract cells that also recive somatic pain signals from the skin surface. The convergent input of the two types of pain signals to a common set of spinal cord neurons is thought to be the basis for referred pain.
Term
Herpes Zoster
Definition
This disorder is characterized by excessive pain in a skin dermatomal distribution resulting from a viral infection of a dorsal root ganglion.
Term
Brown-Sequard syndrome
Definition
This disorder involves a loss of pain sensation on one side of the body coupled with loss of proprioception, precise tactile localization and vibratory sensations on the contralateral side of the body.
Term
Lateral Medullary syndrome
Definition
This disorder is characterized by the loss of pain sensation throughout one entire side of the body and opposite side of the face.
Term
Tic Douloureux
Definition
This disorder causes sever, stabbing pain to one side of the face as it occurs over the sensory distribution of cranial nerves V & IX. Treatment includes severing cranial nerve V just inside the cranium where the sensory and motor functions separate.
Term
No, the brain itself lack pain receptors and is therefore insensitive to pain. Stretching of the dura, tugging on the venous sinuses and stimulation to the blood vessels of the meninges however causes intense pain.
Definition
Yes or NO: Does brain tissue have pain receptors?
Term
Pacinian Corpuscles sense hihg-frequency repetitive stimulation (indentation or pressure) of the skin.
Definition
Vibratory sensation is dependent on the detection of reapidly changing, repetitive sensations. The high frequency end of the repetitive stimulation scale is detected by which type of receptors?
Term
Norepinephrine
Definition
This neurotransmitter is associated with the locus ceruleus
Term
Glycine
Definition
This neurotransmitter typically evokes inhibitory responses.
Term
True
Definition
True or False: In spatial summation, incresing signal strength is transmitted by using greater numbers of sensory fibers.
Term
Equivalent
Definition
Is the range of stimulus intensity detected by the somatosensory sytem less, more or equivalent to that of other sensory systems such as vision & audition?
Term
Vasospasm & eventually ischemia in a sensory area of cortex are thought to be the basis for the prodromal symptoms associated with migranes.
Definition
What is thought to be the cause of prodromal sysmptoms of migrane headaches such as nausea, loss of vision, visual aura or other sensory hallucinations?
Term
It is an "all or none" process, so once intiated, the action potential runs its course to completion.
Definition
Once initiate, the action potential is described as what type of process?
Term
both Tactile and Joint capsule receptors.
Definition
Proprioceptive sensation involves muscle spindles and ________?
Term
slow conducting type C fibers
Definition
Which type of sensory fibers are signals from warm receptors mainly transmitted along?
Term
False: Dendrites cannot initiate or conduct action potentials, but they can transmit electrical potentials by electronic conduction.
Definition
True or False: Dendrites can propagate action potentials.
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