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Neuro Pharm
memorize
21
Medical
Post-Graduate
05/13/2013

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Cards

Term
Glaucom Drugs
a) a-agonists
b)B- blockers
c) Diuretics
d) Cholinomimetics
e) Prostaglandin
Definition
a) Epinephrine- decreases aqueous humor synthesis due to vasoconstriction
1 a) Birominidine-decreaes aqueous humor synthesis
Term
B-blockers : timolol, betaxolol, carteolol
Definition
decreases aqueous humor secretion-
Term
Epilepsy Drug Teratogens
Definition
Phenytoin, carbamezapine, valproic acid ( causes spina bifida)
Term
Steven Johnson Causing drugs
Definition
seizure, drugs, sulfonamides, - "cillins", allopurinol
Term
Agranulocytosis causing drugs carbamezapine, clozapine, colchicine, PTU, methimazole
Definition
carbamezapine, clozapine, colchicine, PTU, methimazole
Term
Hepatotoxic Neuro Drugs:
Definition
Valproic acid, carbamezapine
Term
Induces P450:
Definition
Barbituates, carbamezapine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St. John's wart
Term
Block Na+ Channels:
Definition
carbamezapine, phenytoin, lamotrigine, topiramate, valproic acid
Term
Phynytoin
Definition
1st line drug for tonic clonic, also given for simple and complex..1st line prophylacis for status epilepticus, works by increasing NA+channel inactivation...fosphenytoin for parenteral use
Term
Carbamezapine-
Definition
- 1st line for simple, complex, tonic-clonic
works by increasing Na+ channel inactivation, 1st line for trigeminal neuralgia
Term
Lamotrigine-
Definition
works for simple, complex, tonic clonic...works by blocking voltage gated NA + channels
Term
Gabapentin-
Definition
simple, complex, tonic- clonic...designed as GABA analog, but primarily inhibits HVA Ca+2 channels..also used for peripheral neuropathy, bipolar disorder, postherpatic neuralgia
Term
Topiramate
Definition
blocks na channels, increases gaba action
Term
Phenobarbital- simple, complex, tonic- clonic
Definition
increases Gaba action, 1st line in pregnant women, children
Term
Valproic Acid-1
Definition
increases NA channel inactviation, increases gaba concentration, used for myoclonic seizures
Term
Ethosuxamide- 1st line for absence seizure
Definition
blocks thalamic t-type Ca channels
Term
benzodiazepines (diazepam or lorezepam )
Definition
1st line for acute status epilepticus, increases Gaba action, also used for seizures of eclampsia
Term
Tiagabine- simple and complex
Definition
inhibits gaba reuptake
Term
vugabatrin-simple, complex
Definition
irrevirsibly inhibits GABA transaminase, increases gaba
Term
Levetiracetam (Keppra)- simple, complex, tonic- clonic
Definition
unknown may modulate GABA an glutamate release
Term
Epilepsy Drugs side effects
Definition
diplopia, sedation, ataxia, nystagmus, dizziness
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