Term
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Definition
- MOA: Inhibits phosporylation of IP1; uncouples G Prot to AC, substitutes for Na
- USE: bipolar disorder(manic, normal and depressive); not for major depressive
- TOX: 1mEq/-->GI distress, >2mEq/L-->hypotension, arrythmias, ataxia, convulsions
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Term
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Definition
- MOA: tricyclic antidepressant, 1)5HT reuptake inhib, 2) muscarinic and a1R antagonist
- USE: mod to severe depression, depressive phase of bipolar, enuresis, panic disorder
- TOX: Musc antag: tachycardia, mydriasis, decr GI motil, secretions, blood flow to erectile tissue. a1 antagonism: hypotensio->tachycardia, decr ejaculation, decr CNS excitation
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Term
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Definition
- MOA:tricyclic antidepressant, 1) NE reuptake inhib. 2ndary amine
- USE: mod to severe depression, depressive phase of bipolar, panic disorder, chronic pain, enuresis, not for pts with Cardiac Ds
- TOX: tachycardia, mydriasis, decr GI tone/motility/secretions, decr blood flow to erectile tissue. Hypotension, decr ejac, decr CNS excitation
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Term
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Definition
- MOA: MAOI, works on A and B
- USE: mod to severe depression
- TOX: postural hypotension/tachycardia, insomnia, weight gain, arrythmias, coma
- INTERACTIONS: high plasma prot binding, other sympathomimetic agents and some foods
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