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Neuro I
Neurotransmitters
37
Biology
Undergraduate 4
10/04/2015

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Term
Acetylcholine (location)
Definition
Neuromuscular junction, Peripheral Nervous System, and in Central Nervous System with nicotinic and muscarinic acetylcholine receptors
Term
Acetylcholine (Function)
Definition
Modulatory NT in CNS for reward, learning, and memory. Primary NT for PNS autonomic neurons
Term
Acetylcholine (Disease/Toxin)
Definition
Nicotine activate nicotinic receptors
Botulism toxin- inhibits release of ACh
Black Widow Venom- stimulates release of ACh
Myasthenia Gravis- disease attacks nicotinic receptors
Term
Nicotine
Definition
Acetylcholine Nicotinic receptors
Term
Botulism toxin
Definition
Acetylcholine release inhibition
Term
Black widow venom
Definition
Stimulate ACh release
Term
Myasthenia Gravis
Definition
Disease attacks Nicotinic receptors in skeletal muscle
Term
Catecholamines
Definition
Dopamine and Norepinephrine
Term
Idolamines
Definition
seratonin
Term
Dopamine (Function)
Definition
Initiation of voluntary movement
Thought, attention, motivation,learning, reward
Term
L-Dopa
Definition
Treatment for Parkinson's Disease (precursor of dopamine)
Term
Amphetamines
Definition
Increase release of dopamine and norepinephrine
Term
Cocaine and methylphenidate (Ritalin)
Definition
Inhibit reuptake of dopamine
Term
MAO
Definition
Monoamine oxidase breaks down NT's in cell (norepinephrine, epinephrine, serotonin, and dopamine)
Term
MAO-I
Definition
Treats depression inhibits MAO break down of NT in cells
Term
Parkinson's Disease
Definition
Dopamine producing neurons die
Term
Schizophrenia
Definition
Overactive dopamine
Term
Norepinephrine (Function)
Definition
Sympathetic Nervous System "Fight or Flight"
Sleep, wakefulness, and attention
Term
Norepinephrine drugs
Definition
Selective Norepinephrine reuptake inhibitors used to treat ADD and ADHD
Term
Serotonin
Definition
mood,appetite,sleep/wakefulness, aggression, pain regulation,dreaming
Term
SSRI's
Definition
Selective Serotonin Reuptake inhibitors block reuptake of serotonin
Term
MDMA (Ecstasy)
Definition
Forces reuptake transporters to work in reverse
Term
LSD
Definition
Direct agonist for serotonin
Term
Glutamate
Definition
Ubiquitous, primary neurotransmitter is the eye, brain, and spinal chord
Term
Excitotoxicity
Definition
When neurons stop producing ATP, pumps that maintain resting membrane potential stop functioning. Calcium floods cells, and calcium causes release of glutamate which floods brain and spinal chord. Flooding calcium results in overproduction of enzymes which break down lipids, proteins, and nucleic acids. This is related to ALS and Alzheimer's
Term
NMDA and AMPA
Definition
Glutamate receptors
Term
GABA
Definition
Principle inhibitory neurotransmitter in brain
Term
benzodiazepines like Valium
Definition
Reduce anxiety, promote sleep, and relaxation by binding GABA receptors
Term
Alcohol
Definition
GABA agonist, Glutamate antagonist
Term
Glycine
Definition
Principle inhibitory NT in spinal cord
Term
Endocannabinoids
Definition
Not stored in vesicles. Membrane permeable, diffuse from post synaptic neuron in synaptic cleft.
Term
Anandamide
Definition
Endogenous endocannabinoid ligand
Term
THC
Definition
Exogenous Endocannabinoid ligand
Term
CB-1
Definition
Metabotropic endocannabinoid receptor that stops influx of Calcim
Term
Opioids
Definition
Endogenous painkillers endorphins lcated in areas that detect nociception
Term
Morphine and Heroin
Definition
Opioids that stimulate opiate receptors
Term
Methadone
Definition
Synthetic opioid used to treat opioid dependence
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