Term
| what NT is most implicated in shcizophrenia? |
|
Definition
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|
Term
what is the meaning of postive schizophrenia symtpoms?
exs?-4 |
|
Definition
they are an increase in the abnormal behaviors
deusions, halucinations, movements, thoughts |
|
|
Term
what is the meaning of negative schiz symtpoms?
Exs?-3 |
|
Definition
this is absence of behaviorus found in heathy ppl
loss of interest, oss of emotion, soica withdrawa |
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Term
| which can occur months before the other, postive or negative symptoms? |
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Definition
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Term
what may be the most debilitating type of symtpom in schiz?
why? |
|
Definition
cognitive
bc interfere with performing routine tasks |
|
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Term
| what is the meaning of cognitive symtpoms of schiz? -3 |
|
Definition
probelms with thought process
cant make sens eof info, cant pay attention, memeory |
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Term
| what is the mechanism of action of classical antipsychotics? |
|
Definition
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Term
| bocking the D2 recpetor causes an improvement of what type of symtpoms? |
|
Definition
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|
Term
| the D2 antagonism does what for negative and cognitive symtpoms? |
|
Definition
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|
Term
| what is the action of classical antipsychotics on the striatal pathway? -2 |
|
Definition
| EPS and tradive dyskinsesia |
|
|
Term
| what is the action of classical antipsychotics on the tuberoinfundibular pathway? |
|
Definition
|
|
Term
| what receptors do the 1st generation antipsychotics block? (classical) -4 |
|
Definition
|
|
Term
| what does the blocking of H1 do? -2 |
|
Definition
|
|
Term
| what does blokcing the M1 receptor do? -3 |
|
Definition
constipation
dry mouth
blurred vision |
|
|
Term
| what does blocking of alpha 1 receptor do?-3 |
|
Definition
|
|
Term
| what are the 1st generation antipsychotics-5 |
|
Definition
chlorpromazine
thiothixene
fluphenazine
haloperidol
thioridazine |
|
|
Term
| what is the generic of thorazine |
|
Definition
|
|
Term
| which classical Antipsy has the aliphatic side chain? |
|
Definition
|
|
Term
| what is potency fro D2 for chlorpromazine? |
|
Definition
|
|
Term
| what receptors does chlorpromazine block? |
|
Definition
|
|
Term
| what is the generric of mellaril |
|
Definition
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|
Term
| which classic Antipsy has a high anticholinergic ability |
|
Definition
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|
Term
| thioridizine has the possibiity of what cardiac effect? |
|
Definition
|
|
Term
| which classic antipsy has a phenothiazine tricyclic nucelus? |
|
Definition
|
|
Term
|
Definition
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|
Term
what is the potency of fluphenazine?
what does this mean? -3 |
|
Definition
HIGH
reduced sedation, anticholinergic, and hypotensive |
|
|
Term
| which classic antipsy cna be given for chronic therapy with 1gs-24 day 1/2 life? |
|
Definition
|
|
Term
| what are the other types of fluphenazine dru |
|
Definition
trifluperazine
perphenazine |
|
|
Term
| what drug has thizanthene tricyclic nucelus? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| which drug has butyrophenones? |
|
Definition
|
|
Term
| which drugs have a hgih potency with lower doses adn so have low ADEs except the ones associated with D2 blocking? |
|
Definition
haloperidol
thiothixene
fluphenazine |
|
|
Term
| effects of antipsychotics (general)-4 |
|
Definition
postivie symtpoms reduced
sedation
improved mtoivation
reduced agitation/aggression |
|
|
Term
| acute affect of the classical antipsychotics can happen soon, how long for chronic? |
|
Definition
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|
Term
acute effects of classic antipsychotics-2
what is overall effect of these? |
|
Definition
compromise the presynaptic negative feedback
-other DA receptors are stimulated;
-reduction in DA is blunted |
|
|
Term
chronic effects of classical antupsychotics-2
over all effect? |
|
Definition
D2 blocked so limited neg feedback
DA storage/release compromised;
-DA transmission decreased |
|
|
Term
| the striatum is where you see the effects of dopamaine on what disease? |
|
Definition
|
|
Term
what causes extrapyramidal symtpoms from antispychotic drugs?
what are the symptoms? |
|
Definition
block dopamine so it cant neutralize the ACh effects on GABA;
unctonrollable motor functioning |
|
|
Term
| does dopamine in the hypothalmus inhibit or increase prolactin release? |
|
Definition
|
|
Term
| what is the effect of hyperprolacinaemia from the classical antipsychotics?-4 |
|
Definition
amenorrhea
male infertility
galactorea
gynecomastia |
|
|
Term
| dopamine in this region has an emetic effect |
|
Definition
|
|
Term
| how do the classical antipsychotics effects emesis? |
|
Definition
| blocks the D2 in the emetic center so has antiemetic effect |
|
|
Term
| what are the extrapyramidal effects of the D2 blocking?-4 |
|
Definition
pseudoparkinsonism
dystonia
akathesia
tardive dyskinesia |
|
|
Term
| what side effects not related to the D2 blokcing do ppl build a tolerance for? |
|
Definition
|
|
Term
| side effects not related to D2 blocking |
|
Definition
GI
seizures
neuroleptic malignant syndrome |
|
|
Term
| clinical pearls of the classic antipsychotics |
|
Definition
no addictive potential
quite safe
tight, long lasting binding to DA recptor-> more dopamine effects (good and bad ones) |
|
|
Term
what type of pts eliminate the classical antipsychotics more rapidly?
why? |
|
Definition
|
|
Term
| how are classical antipsychotics mostly eliminated? |
|
Definition
|
|
Term
| PK of classical antipsychotics-4 |
|
Definition
lipophillic
protein bindings
long half life
crosses BBB |
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|
