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high/low hepatic clearence is what cna limit drug getting to brain? |
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high/low protein binding makes it difficult fro drug to get to brain? |
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main probelm for neuro drug development is what? |
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what is the Lipniski's rule of 5? which one did Veber come up with |
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MW<500 lopP<5 <5 H donors < 10 H acceptors <10 rotatable bonds; the rotabale bond limit |
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lipinski's rule of 5 only applies to what type of neuro drugs? |
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Log P measures lipphilicty in the absence of what? |
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ionization (so drug is nuetral) |
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sing non ring ond with non H terminal atom |
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want more or less rotabale bonds for oral bioavilability |
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a high Log D means the drug is hydro/lipophillic |
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are H bond donros or acceptors more limitng for crossing BBB? |
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what are the revised rule of 5 for BBB: O and N atoms- PSA- log P Mw Log D |
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O and N atoms <6 Clog P >0 PSA < 70 Mw- 450 log D 1-3 |
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which type of moelcule is bad for BB- base or acid? |
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selective or nonselctive inhibitoin of MAOi increases dopamine? |
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