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Neuro Exam 1
Lecture 3
17
Archaeology
4th Grade
08/21/2013

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Cards

Term
high/low hepatic clearence is what cna limit drug getting to brain?
Definition
high
Term
high/low protein binding makes it difficult fro drug to get to brain?
Definition
high
Term
main probelm for neuro drug development is what?
Definition
BBB
Term
what is the Lipniski's rule of 5?
which one did Veber come up with
Definition
MW<500
lopP<5
<5 H donors
< 10 H acceptors
<10 rotatable bonds;
the rotabale bond limit
Term
lipinski's rule of 5 only applies to what type of neuro drugs?
Definition
oral
Term
Log P measures lipphilicty in the absence of what?
Definition
ionization (so drug is nuetral)
Term
high log P means?
Definition
highly lipophillic
Term
if have low LogP means?
Definition
water soluable
Term
what is a rotabale bond
Definition
sing non ring ond with non H terminal atom
Term
want more or less rotabale bonds for oral bioavilability
Definition
less
Term
what does Log D measure
Definition
ionization
Term
Log D is the change in _
Definition
pH
Term
a high Log D means the drug is hydro/lipophillic
Definition
lipophillic
Term
are H bond donros or acceptors more limitng for crossing BBB?
Definition
H donors
Term
what are the revised rule of 5 for BBB:
O and N atoms-
PSA-
log P
Mw
Log D
Definition
O and N atoms <6
Clog P >0
PSA < 70
Mw- 450
log D 1-3
Term
which type of moelcule is bad for BB- base or acid?
Definition
acid
Term
selective or nonselctive inhibitoin of MAOi increases dopamine?
Definition
nonselective
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