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Neuro Exam 2
Neuro Exam 2
362
Biology
Graduate
11/15/2011

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Term
The spinal cord is continuous with what?
Definition
Brai
Term
where does the spinal cord start and end?
Definition
starts in foramen magnum and ends at the second lumbar vertebra
Term
what is the space between the end of sc at L2 and end of dural sheath at S2 filled with? What is it called?
Definition
filled with dorsal and ventral roots. they are called cauda equina.
Term
at what vertebra does the sc end?
Definition
L2
Term
what happens to the diamter of sc as go from superior to inferior?
Definition
goes from larger to smaller
Term
how many enlargements happen in the sc?
Definition
2
Term
what are the purposes of the 2 enlargements in the spinal cord?
Definition
where nerves leave and enter cord to supply upper and lower limbs
Term
what are the names of the 2 enlargements of the sc?
Definition
cervical enlargement and the lumbosacral enlargement
Term
how many sections of the sc are there?
Definition
5
Term
hat are the names of the 5 sections of the sc?
Definition
cervical, thoracic, lumbar, sacral, and coccygeal
Term
how are spinal nerves numbered?
Definition
starting at superior end of each region
Term
how many pairs of nerves are in the sc?
Definition
31 pairs
Term
how many spinal pairs are in each section of the sc?
Definition
8C, 12T, 5L, 5S, and 1Co
Term
what does dermatome mean?
Definition
spinal cord segments are related to areas of skin and muscle
Term
what is a dermatomal map
Definition
indicates sensory distribution of each spinal nerve
Term
what letter does the cross section of the spinal cord look like
Definition
H
Term
Gray matter is where in the sc and contains what
Definition
in the center and contains cell bodies, dendrites, synapses, and ganglia
Term
white matter is where in the sc and contains what
Definition
in the peripheral portion and contains axons
Term
what are the two clefts that separate the two halves of sc? Which one is bigger?
Definition
anterior median fissure and posterior median sulcus. the anterior median fissure is bigger.
Term
what are the 3 sections of white matter
Definition
dorsal column, ventral column, lateral column
Term
is white matter grouped in columns or horns?
Definition
columns
Term
what is the dorsal column? where is it located?
Definition
in the back of sc cord in white matter. it has the sensory neurons
Term
what is the ventral column? where is it located?
Definition
it's in the front of sc in white matter. it contains motor neurons
Term
what is the lateral column? where is it located?
Definition
in the lateral portion of the white matter and has the sympathetic neurons for the ANS (autonomic function)
Term
what are the 3 sections of greay matter
Definition
dorsal horn, anterior horn, lateral horn
Term
are the sections in the gray matter horns or columns?
Definition
honrs
Term
what is the dorsal horn? where is it located?
Definition
in the back of the gray matter. it contains mostly sensory cell bodies
Term
where is the anterior horn located? what does it contain?
Definition
located in front of gray matter. contains cell bodies of skeletal motor neurons
Term
where is the lateral horn located? what does it contain
Definition
located in lateral gray matter and contains autonomic cell bodies
Term
where are the cell bodies of the sympathetic system found in lateral horn?
Definition
between T1 and L3
Term
The parasympathetic fibers are found where in the sc? Do they form a distinct lateral horn?
Definition
found between S2 and S4. No.
Term
dorsal roots of sc are afferent or efferent? what types of axons do they carry?
Definition
Afferent. Sensory
Term
what does the dorsal root ganglia contain?
Definition
cell bodies of sensory neurons
Term
where does the dorsal root project to?
Definition
posterior horn
Term
Describe the route of a signal from sensory receptor in the skin the the posterior horn
Definition
Goes from: sensory receptor to afferent neuron to the dorsal root ganglion to the dorsal root to the posterior horn
Term
are ventral roots efferent or afferent? what do they contain
Definition
efferent. motor axons
Term
what type of neuron is located in the anterior horn
Definition
somatic neurons
Term
what type of neuron cell bodies are found in the lateral horn
Definition
autonomic neurons
Term
what 2 things combine to form the spinal nerves
Definition
dorsal and ventral roots
Term
describe the path of a signal from posterior horn to effector organ?
Definition
goes from posterior horn to ventral/lateral horns to ventral root to efferent neuron to spinal nerve to effector organ
Term
axons and its schwann cells are surrounded by what in sc
Definition
endoneurium
Term
groups of axons are surrounded by what? what do they form?
Definition
perineurium. fasicles.
Term
what surrounds nerve fasicles? what do they form?
Definition
epineurium. forms the nerve
Term
what is the epineurium continuous with in the CNS?
Definition
dura mater
Term
what are the 3 main ascending pathways in the sc
Definition
lateral spinothalamic, dorsal column, and spinocerebellar
Term
how are nerves named
Definition
indicate origin and termination
Term
what are the two main tracts involved in conscious sensation
Definition
lateral spinothalamic and dorsal column
Term
the lateral spinothalamic tract and dorsal column both consist of how many neuorns
Definition
2-3
Term
where do the lateral spinothlamaic and dorsal columns pathways terminate
Definition
thalamus
Term
what does cortico mean
Definition
starts in cortex
Term
cortiocospinal is motor or sensory
Definition
motor
Term
sensory pathways go from where to where
Definition
sc to brain
Term
motor pathways go from where to where
Definition
brain to sc
Term
what type of information does the laeral spinothalamic tract transmit
Definition
pain and temperature
Term
where does the lateral spinothalamic tract cross over
Definition
almost immediately after entering the sc
Term
lateral spinothalamic transmits info from receptors where to where?
Definition
skin to brain
Term
what is the only sense that doesn't go through the thalamus
Definition
smell
Term
what happens if have a lesion in spinothalmaic tract
Definition
loss of pain and temp contralaterally below level of lesion
Term
the dorsal column transmits info regarding what 3 things
Definition
touch (two-point discrimination), pressure, and conscious proprioception
Term
where do the fibers of teh dorsal column cross
Definition
travel up ipsilaterally and cross at the medulla
Term
what is conscious proprioception
Definition
ability to know where your limbs are
Term
what is stereognosis
Definition
abilitly to know something by touch
Term
what sensation comes from the combo fo the spinothalamic pathway and the dorsal column
Definition
light touch
Term
what are the main tracts involved in conscious senesation
Definition
spinothalamic and dorsal column
Term
the spinocerebellar tract is resposnsibile for what
Definition
unconscious proprioception
Term
where do the fibers cross in spinocerebellar
Definition
they don't... they remain ipsilateral
Term
are fibers in cerebellum usually contra or ipsi? in the cerebrum?
Definition
cerebellum: ipsilateral
cerebrum: contralateral
Term
corticospinal goes from where to where?
Definition
brain to spine
Term
where do fibers cross in the corticospinal pathway?
Definition
stay ipsilateral and cross at medulla
Term
is the corticospinal descending or ascending?
Definition
descending
Term
where are the ell bodies located for the upper motor neurons in the descending pathway
Definition
motor cortex, cerebellum, or brainstem
Term
where do the fivers cross for the upper motor neurons in the descending pathways
Definition
at the level of the medulla
Term
where do the upper motor neurons in the descending pathway synapse with the lower motor neurons
Definition
brainstem or spinal cord
Term
where are teh cell bodies located for the lower motor neurons in the descending pathway
Definition
anterior horn of sc or cranial nerve nuclei
Term
where do the axons extend to from the lower motor neurons
Definition
skeletal muscle
Term
LOOK OVER SPINAL CORD LESIONS AND LOOK AT PATHWAY
Definition
LOOK OVER SPINAL CORD LESIONS AND LOOK AT PATHWAY
Term
what is a reflex? describe its pathway
Definition
an automatic response to a stimulus through a reflex arc. The AP goes through peripheral nerve, sc, and out motor nerve w/o ever going through the brain
Term
are reflexes excitatory or inhibatory
Definition
some are excite, some are inhibit
Term
what are teh five components of a reflex
Definition
sensory receptor, sensory neuron, interneuron, motor neuron, effector organ
Term
describe pathway of stretch reflex
Definition
1) sensory receptors called muscle spindles detect suddent stretch of muscle
2) sensory axons synapse direcetly with motor neurons which innervate muscle
3) motor neurons cause the muscle to contract
Term
what is a golgi tendon reflex
Definition
comes from tendons, tells you stretching tendon too much, and is what keeps us upright
Term
what does the golgi tendon reflex prevent
Definition
prevents muscles that are contracting from putting excessive tension on the tendons
Term
describe golgi tendon reflex
Definition
1) when muscle contracts, the tnedons are strecthed stimulating sensory neurons
2) sensory neurons synapse with inhibitory interneurons
3) interneurons synapse with motor neurons that cause the muscle to relax
Term
what is the withdrawal reflex
Definition
removes a body part from a painful stimulus
Term
descrive withdrawal reflex
Definition
1)pain receptors cause an action potential in sensory neurons
2) sensory neurons synapse with excitatory interneurons
3) interneurons synapse with motor neurons
4) flexor muscles are stimulated to remove the limb from painful stimulus
5) at the same time inhibitory neurons send AP to motor neurons to relax the extensor muscles
Term
what is the crossed extensor reflex
Definition
allows support of body weight during withdrawal reflex
Term
descrive crossed extensor reflex
Definition
1) collateral axons extend through the white commissure and synapse with motor neurons on the opposite side of the sc
2) while the withdrawal reflex causes flexion in one lower limb, the crossed extensor reflex causes extension in the opposite lower limb
Term
the brain is broken down into how many main divisions
Definition
4
Term
what are the 4 main divisions the brain is broken down into
Definition
cerebrum, brainstem, cerebellum, diencephalon
Term
what does the cerebrum control
Definition
conscious activities
Term
what does the brainstem do
Definition
connects cerebrum to sc and transfers info from cerebrum to rest of body
Term
what are the 3 sections of the brainstem
Definition
midbrain, pons, medulla
Term
what does the cerebellum do
Definition
controls muscle movement and tone
Term
where is the diencephalon located
Definition
between brainstem and cerebrum
Term
what are teh 4 main sections of the diencephalon
Definition
thalamus, subthalamus, epithalamus, and hypothalamus
Term
where does the thalamus lie in regards to lateral ventricle
Definition
inferior to it
Term
what surrounds the thalamus
Definition
internal capsule
Term
what does the thalamus do
Definition
relay center... decides what's important to get to cerebrum and what's not
Term
what does the subthalamus do
Definition
contains nerve tracts and nuclei... more involved in movement
Term
the subthalamus is part of what
Definition
basal nucleus
Term
where is the epithalamus located in regards to thalamus
Definition
posterior to it
Term
what important thing does the epithalamus contain
Definition
pineal body
Term
what does the epithalmaus do
Definition
habenular nucleir respond to olfactory stimulation
Term
where is the hypothalmus located in relation to thalamus
Definition
below and a little in front
Term
what does the hypothlamaus do
Definition
maintains homestasis and regulates endocrine function
Term
what is the infundibulum
Definition
connects hypothalamus and pituitary gland
Term
describe shape of thalamus
Definition
like a yo-yo: two large portions laterally and connected by a stalk (interthalamic adhesion) in the center
Term
what is the interthalamic adhesion
Definition
connects two portions of thalamus in center
Term
what is the space between the two lateral portions of the thalamus and surrounds the inthalamic adhesion called
Definition
third ventricle (in center of thalamus)
Term
the thalamic nuclei can be classififed into how many groups
Definition
3
Term
what are the three functions groups of thalamic nuclei
Definition
relay nuclei, association nuclei, nonspecific nuclei
Term
what are the 2 major relay centers of the relay nuclie of thalamus
Definition
sensory relay center, motor relay center
Term
what is the relay nuclei of thalamus
Definition
convey information from sensory systems, basal ganglia, or cerebellum to cerebral cortex. major function is to regular info that goes to and from cerebrum
Term
what is the sensory relay center in thalamus
Definition
most sensory neurons synapse in the thalamus. the thalamus then sends projections to the cerebral cortex.
Term
sensory information from body and face synapse where
Definition
ventral posterior nuclei
Term
medial geniculate nucleus receiced what kind of information from where? where do the axons the travel?
Definition
receives auditory information from the inferior colliculus. axons then travel to auditory cortex
Term
the lateral geniculate nucleus receives what kind of information from where? where does it then send its axons?
Definition
receives visual information from optic tract. the axons then travel to the visual cortex
Term
describe the motor relay center of the thalamus
Definition
ventral anterior nuclei and ventral lateral nuclei are inovled in communicating motor information between the basal nuclei, cerebellum, and motor cortex
Term
what does the association nuclei aof the thalamus do
Definition
prcoess emotional and memtory information as well as integrate different types of information
Term
describe anterior and medial nuclei of association nuclei of thalamus (job and location)
Definition
connceted to limbic system and prefrontal cortex and influence mood
Term
describe job and location of lateral posterior nuclei and pulvinar nuclei n the association nuclei of thalamus
Definition
connect to other thalamic nuclei and integrate sensory information
Term
describe job and location of lateral dorsal nucleus of association nucleus of thalamus
Definition
connected to other thalamic nuclei and cerebral cortex to influence actions associated with strong emotions
Term
what are the three nuclei of the nonspecific nuclei of thalamus
Definition
midline, intralaminar, and reticular nuclei
Term
what do the nonspecific nuclei do in thalamus
Definition
regulate consciousness, arousal, and attention
Term
where is subthalamus located in regards to thalamus
Definition
inferior
Term
the subthalamus contains nerve tracts that are heading for what 2 things
Definition
thalamus and subthalamic nuclei
Term
function of subthalamus (what is it associated with)
Definition
associated with basal nuclei which are inovled in motor control
Term
a small portion of which 2 things are located in subthalamus
Definition
substantia nigra and red nucleus
Term
where is the epithalamus located
Definition
superior and posterior (mostly poserior) to thalamus
Term
what 2 things does the epithalamus consist of
Definition
habenular nuclei and pinal body
Term
what is the function of the pineal gland? how many do we have?
Definition
thought to play a role in the onset of puberty and may influence sleep-wake cycle (circadian rhythm). only have 1.
Term
after age of 17, what happens to pineal gland?
Definition
calcareous concretions accrue and is useful landmark in xrays.
Term
does the pineal gland still function when calcified
Definition
yes
Term
what is habenular nuclei
Definition
integrates smells and odors; influenced by smell; involved in emotional response to odor
Term
where is hypothalamus located
Definition
inferior portion... only part you can see in intact brain
Term
what part of diencephalon are the mammillary bodies located
Definition
hypothalamus
Term
what are the mammillary bodies
Definition
bulges on posterior surface of hypothalamus; involved in emotional response to odor; may also be inolved in memory and sense of direction
Term
what is the infundibulum
Definition
stalk found in inferior hypothalmus, connects the hypothalamus to poserior pituitary gland
Term
functions of hypothalamus
Definition
1) aids in controlling endocrine system
2) overall control system for ANS
3) promotes or inhibits eating or drinking
4) important in mood, motivation, and emotion
5) interacts with reticular activating system to coordinate the sleep-wake cycle
Term
what does the hypothalamus do in the endocrine system
Definition
regulaes secretion of pituitary gland; controls metabolism, reproduction, response to stress, and urine production
Term
do afferent or efferent fibers from hypothalamus synpase with neurons in ANS
Definition
efferent
Term
stimulation of posterior hypothalamus produces a ____ reponse and stimulation to anterior hypothalamus produces a ______ response
Definition
sympathetic; parasympathetic
Term
what does the hypothalamus and ANS do?
Definition
controls HR, urination, digestion, blood vessel diamter, and body temp by stimulatiang sweating or shivering
Term
the role of controlling emotion in hypothalamus is part of what system
Definition
limbic
Term
what does the hypothalamus do with thoughts and emotions?
Definition
generates ANS response
Term
what sits in the sella turcica
Definition
pituitary gland
Term
what is the hypophysis
Definition
another term for pituitary gland
Term
what does the pituitary gland do
Definition
secretes hormones that regular body function
Term
what regulates the secretion of the pituitary gland
Definition
hypothalamus
Term
describe strucutre of pit gland
Definition
approx 1 mm in diameter; in sella turcica of sphenoid bone; connected to hypothalamus by infundibulum
Term
Neurohypohysis is ____ pit gland and adenohypohpysis is ___ pit gland
Definition
posterior; anterior
Term
the posterior pit gland is continuous with what
Definition
brain
Term
the outgrowth of inferior brain in area of hypothalamus formed by posterior pit forms what
Definition
indundibulum
Term
secretions from posterior pit are considered what
Definition
neuorhormones
Term
describe pathway of neurosecretory cells
Definition
hypothalamus, through indundibulum, to posterior pituitary
Term
what casues release of neurohormones from pituitary into blood stream
Definition
AP in hypothalamus
Term
the anterior pit arose from what
Definition
outgrowrth of epithelial tissue in roof of embryonic oral cavity
Term
are hormones secreted from anterior pit considered neurohormones?
Definition
no
Term
LOOK AT CHART WITH HORMONES FROM ANTERIOR PIT GLAND
Definition
LOOK AT CHART WITH HORMONES FROM ANTERIOR PIT GLAND
Term
what are the 2 hormones secreted by posterior pit
Definition
antidiuretic hormone (ADH) and oxytocin
Term
what is the function of ADH
Definition
maintaing osmoloarity and volume of extracellular fluid
Term
Relate water absorption of kidneys, release of ADH, and excretion of urine
Definition
* Lack of water intake with cause an increase in ADH release. Less urine will be produced.
* Increased water intake will cause a decrease in ADH release. This will allow more urine to be released
Term
How does a decrease in BP also cause release of ADH?
Definition
ADH causes constrcition of blood vessels. Constriction of bv that pass through the kidneyes futher slows the urine production (because urine is derived from blood as it passes through kidneys. If there is less blood, there will be less urine).
Term
what is oxytocin
Definition
involved in giving birth; stimulates smooth muscle in uterus causing discahge of fetus during delivery; causes milk expulsion in lactating females
Term
LOOK AT PNEUMONIC TO REMEMBER PIT HORMONES
Definition
LOOK AT PNEUMONIC TO REMEMBER PIT HORMONES
Term
what is most common area in brain to get tumor
Definition
pituitary gland
Term
pit tumors account for what % of intracranial neoplasms
Definition
10%
Term
describe growth of pit tumor
Definition
most benign and slow growing
Term
symptoms of pit tumor
Definition
HA, nausea and vomiting, sexual dysfunction (FSH, LH), high BP (ADH), diabetes (ACTH, GH), irregular periods and lacation with no pregnancy (prolactin), acromegaly: hands, feet, and face are larger than normal (GH), Cushing's disease: fat builds up in face, back and chest, and arms and legs become very thin; EOM disorders due to invasion of cavernous sinus; VF loss (bitemporal defects)
Term
goals of treatments for pit tumor
Definition
normalization of excess pit secretion; ridding patient of signs or symptoms of abnormal hormone secretion; shrinkage of large masses to relieve compression of adjacent structures
Term
treatment options for pit tumor
Definition
transsphenoidal surgery (through nose); radiation; medications to block pit from producisng too many hromones
Term
limbic system includes parts of what 2 strucutres of brain
Definition
cerebrum and diencephalon
Term
limbic lobe includes:
Definition
cingulate gyrus, parahippocampal gyrus, septal area
Term
what does the limbic system all refer to
Definition
cingulate gyrus (just above corpus callosum); parahippocampla gyrus and hippocampus (medial side of temporal lobe); amygdala (front of hippocampaus... emotional response to diff stimuli; various nuclei (anterior and medial nucleir of thalamus, dentate nucleus of hippo, septal nuclei); orbiotofrontal cortex; hypothalamus inclduing mammillary bodies; tracts above areas
Term
functions of limbic system
Definition
emotions (fear, social gestures, organ function), memory, autonomic response to smell, emotion, mood and other functions; motivation; mood; senessations of pain and pleasure; reproduction; nutrition
Term
emotional behabiors and motivation are regualted by:
Definition
amygadala, anterior cingulate cortex, orbitofrontal cortex, areas in hypothalamus, anterior nuclei of thalamus
Term
emotions are intimately tied to decision making
Definition
destruction of amygdala (causes "lurch" in stomach) bilaterally causes animals to be fearless and placid. the don't respond to threats or social gestures
Term
excessive ____ is associated with stress-related disorders
Definition
cortisol
Term
what structures are essential from prcoessing of memories
Definition
hippocampus, medial thalamic nuclei, posterior limbic cortex (including cingulate and parahippocampal gyri), amygdala, and septal nuclei
Term
what are the three distinct types of memory
Definition
emotional, declarative (recalling facts, past events, concepts), and procedural
Term
emotional memory
Definition
invovles amygdala; damage to either of the other 2 memory systems doesn't affect this one; destruction of amygdala impairs ability to learn or remember the appropriate emotional and autonomic response to stimuli; amygdala is also involved in weighting the importance of facts that will be committed to memory (a memory associate with a strong emotion is more likely to be remembered)
Term
declarative memory
Definition
requires attention during recall; three stages: immediate (lasts only 1-2 seconds; processed only in sensory cortex), short term (lost after 1 min unless continously reheresed), long term (occurs after short term has been processed); parts of limbi system are essential for converting short-term memory to long term memory (memories aren't stored in limbic structures); brain changes that are thought to occur with long term memeory of called long-term potentiation
Term
procedural memory
Definition
practice is required to store procedural memories; once skill is learned, attention is not required to perform task; three stages for learning a skill: cognitive (person trying to understand task; may talk their way through a task), associative (person refines the movements according to what they find to be most effectiuve mehtod), autonomous (movement are automatic, not requiring attention)
Term
what 2 things does the cerebrum consist of
Definition
diencephalon and cerebral hemispheres
Term
where is the gray and white matter in the brain
Definition
gray is on top (very thin and covers cerebral hemispheres) and white is below (more dense; subcortical)
Term
different densities in the cortex may cause what in trauma? What is this?
Definition
it may cause shearing. shearing is breaking off at connection and happens depending on speed/force (silly puddy example)
Term
how many total cells are in cerebrum? how many total synapses?
Definition
10^10; 10^15
Term
all gray matter areas of cortex contain ___ cell layers, except for __ and __ which only have 3.
Definition
6; olfactory; medial temporal cortex
Term
3 layers of the olfactory and meidal temporal cortex in gray matter in cerebral cortex
Definition
pyramidal (output cells with long axons); fusiform (spindle shaped output cells project to thalamus); stellate (small inerneurons which remain within cortex)
Term
pyramidal cells
Definition
big; can carry information between layers; cells whose axons leave striate cortex forming tracts
Term
stellate cells
Definition
function within layers of cortex, carry information between layers; don't leave cortex
Term
cortical histology:
1) Molecular layer
2) external granular layer
3) external pyramidal layer
4) internal granular layer
5) internal pyramidal layer
6) multiform layer
Definition
1) mostly axons/dendrites
2) sm pyramidal and some stellate
3) pyramidal communicates with lower layers
4) stellate
5) pyramidal bodies with neurons connect within each other
6) fusiform cells and end of pyramidal
Term
what 3 fibers do myelinated axons have
Definition
projection, commisural, association
Term
projection fibers
Definition
extend from subcortical structures to cerebral cortex to thalamus, basal ganglia, brainstem, and spinal cord; majority travel through the internal capsule (acts as bottle neck); axons fan out to project to/receive from various cortical areas
Term
why does a small lesion in the internal capsule of projection fibers have such a large effect
Definition
cuz it's such a small area
Term
commisural fibers
Definition
link homologous areas of cerebral hemispheres; includes corpus collosum (links hemispheres and anterior and posterior commisures, lets two sides of brain communicate with each other); link areas that have similar functions
Term
association fibers
Definition
connect areas within a hemisphere (short connect adjacent gyri; long connect lobes)
Term
what do commisures?
Definition
connect 2 sides of brain with functions that normally go together (same area to same area)... like verbal and non-verbal communication skills
Term
what are the 4 basic divisions of the cortex
Definition
frontal, temporal, parietal, occipital
Term
what causes the two lobes of cerebrum to look identical but not...
Definition
each lobe is organized into many different functional areas
Term
how many functionl areas are there in the brain? how many are devoted to vision?
Definition
52; 20-25
Term
what are 4 diff ways we think about brain organization
Definition
1) "localization of function" (primary sensory, motor, association)
2) major divisions (parietal, temporal etc)
3) cytoarchitecture (size and density of cell bodies)
4) myeloarchitecture (distribution of myelin fibers... least commonly used way)
Term
what are 4 localization of function
Definition
primary sensory, sensory association, primary motor, association area
Term
what are the 5 functional categories
Definition
1) primary sensory cortex (different intensities and qualities of sensory info... looks at intensity of diff stimuli)
2) sensory association (more complex sensory... take stimulation and put stuff together to something meaningful)
3) motor planning (organize movement... template in brain to move certain way)
4) primary motor (descending control of movement...take plan and execute it)
5) association (controls behaviors, interprets sensation, emotions, memories)
Term
where are the primary sensory areas located? which one is not located here?
Definition
usually on gyri of brain; vestibular
Term
primary somatosensory
Definition
info from tactile and proprioception (know where limbs are in space); location of stimuli; discrimination of shapes, size, texture (identify something by touch with seeing it); nociceptive (pain when appropriate and goes away when pain's gone) and temp pathways more widespread
Term
what happens when have functional loss in the 4 major primary sensory areas?
Definition
somatosensory: loss of tactile localization and conscious propriopception; vestibular: change in awareness of head position; visual: homonymous hemianopia; auditory: loss of conscious localization of sounds
Term
what do sensory association areas do
Definition
analyze sensory input of ONE type of sensory info
Term
what are the 3 sensory association areas? what do they do?
Definition
somatosensory (stereognosis [figure stuff out that you feel] and memory of tactile)
visual (analysis of color, motion, and fixation)
auditory (classification of sounds- compares with memory)
Term
what happens when you have functional loss in the 3 sensory association areas?
Definition
1) asterognosis (inability to recognize objects you feel)
2) visual agnosia (identify size and shape but can't put name to it) or prospagnosia (can't recognize faces)
3) auditory agnosia (can't recognize language... L: speech R: other words/sounds)
Term
primary motor area
Definition
upper motor neurons (start in motor cortex and go to brain stem... tell things what to do); most contralateral voluntary movement; some bilateral (things that usually work together... like back and forehead); motor planning area
Term
HAL
Definition
Way things are arranged (Head, Arm, Leg)
Head is by the frontoparietal lobe
leg is by midline between cerebral hemisperheres
Term
in communication, the dominant side of the brain pays attention to ___ and the non-dominant side pays attention to ___
Definition
words; verbal cues
Term
what are the 3 areas of the motor planning area and what do they do?
Definition
1) supplementary (initiation of movement- get head and eyes right)
2) premotor (trunk and girdle- ready to move)
3) Broca's (in left hemisphere... movement of mouth, grammar: planning to speak/formulate)
Term
what happens when you get motor area lesions
Definition
loss of fractionaion of movement with paresis (using fingers in controled way); apraxia (inability to execture voluntary movement even if muscles are fine- signla from brain is wrong); perseveration; broca's aphaisa (non-fluent aphasia... get 1 words out at a time and words that come out don't make sense)
Term
what are association areas
Definition
areas of cortex not directly involved with sensation or movement... do lots of different things
Term
what are the 3 association areas and what do they do
Definition
prefrontal (self-awareness; planning; not fully developed until 25); parietotemporal (sesnory integration, spatial relationsl, language); limbic (emotion, memory, fear)
Term
what happens when you have association area lesions
Definition
loss of executive functions and divergent thinking; disturbances of personality and emotions; wernicke's aphasia (ramble in a non-fluent way... doesn't make any sesnse) and/or neglect
Term
both language and speech are loaclized in what hemisphere in 95% of ppl? what are the 2 communication areas?
Definition
left hemispehere; wernicke's (comprehension) and broca's (expressive)
Term
wernicke's area
Definition
left parietotemporal cortex; mediates comprehension of spoken language; corresponding area in RIGHT hemisphere mediates interpretation of nonverbal communications (gestures, facial expession, tone of voice) and spatial relation between body and external world; pays attention to what hear in spoken area and other side (non-verbal cues)
Term
Broca's area
Definition
left frontal lobe; mediates language output (speech); corresponding area in RIGHT hemisphere mediates instructions for nonverbal communication
Term
pathology of optic nerve affects what entrance skills test?
Definition
visual acuity
Term
pathology to ____ optic nerve rarely affects VA
Definition
posterior
Term
__ findings are more valuable in determination of pathaology than negative findings
Definition
postive; negative
Term
what is coup-contrecoup
Definition
coup: brain hits forward wall
contrecoup: hits back wall
brain going back and forth with force after impact; bottom of skull is rough and can cause bleeds and other problems
Term
neurological defects from frontal lobe pathology
Definition
seizures; mental changes (depression, euphoria, denial... deny stymptoms cuz of frontal lobe deals with self-awarness: they're not aware of their lack of recognition); inappropriate language or behavior (may act out but not directed at anything... generalized); nonfluent aphasia (Broca's... 1 word at a time); confabulation (lying about things but have gap in memory and pull up missing details with another memory); anosmia (smell problems); contralateral hemiparesis and grasping reflex (difficulty moving one side)
Term
frontal lobe lesion would fail what two tests
Definition
trailmaking test, wisconsin card sorting
Term
parasellar tumors account for __% of all CNS neoplasms
Definition
25%
Term
pituitary adenoma
Definition
most common tumor in this region; age group 20-40; grow rapidly during pregnancy; prolactin assay positive in 75% of adenomas; if get increase in HA during pregnancy, get concerned that it's homrone driven tumor
Term
neurological defects from chiasmal pathology
Definition
often neurologically silent, severe HA, amenorrhea (lose your period), EOM palsy, decreased consciousness, loss of libido, secondary hypothyroidism (pit sets off chain of events that stimulate thyroid)
Term
temporal lobe lesion
Definition
tumors more common than stroke (gliomas most common, meningiomas second...slow growing); optic radiations supplied by middle cerebral artery; "pie in the sky"
Term
neurological defects from temporal lobe pathology
Definition
formed auditory and visual hallucinations; uncinate (from uncus area of temp lobe) and psychomotor first: EPILEPSY; deja vu and jamais vu (opposite of deja vu) experiences; confusion; automatic behavior (inappropriate behaviors); "fluent" aphasia (wernicke's aphasia); directed aggression (inappropriate/aggressive behavior directed at something/someone); bilateral tinnitus (rining in ear)
Term
what are the 2 major processing streams from the striate cortex
Definition
1) ventral or temporal ("what it is") Parvo stream (specific color/detail)
2) dorsal parietal ("where it is") magno stream
Term
ventral stream: "what is is"
Definition
comes from occipital lobe and goes to processing to tell color/detail/faces
Term
parietal lobe lesion
Definition
commonly resulting from throboemoblic stroke; supplied by middle cerebral artery; parietal-occipital border supplied by posterior cerebral artery; primary receptive area for somataesthetic information (tactile defects rather than numbness)
Term
neurological defects from parietal lobe pathology
Definition
disabilities often subtle and rationalized by patients; extinction (ignore one side/neglect one half of body) and attentioanl defects (corporal agnosia and anosognosia for hemiplegia); seizures with sensory focus
Term
how do you know which is your dominate hemisphere
Definition
opposite to which hand you write with
Term
what is a test for neglect
Definition
line bisection or line cancelation
Term
neurological defects from dominat parietal lobe pathology
Definition
difficulties in visual cognitive function and symbolic behavior; alexia (can't read); agraphia (if angular gyrus is involved...can't write); receptive aphasia (dont understand what you're saying... can't process words)
Term
nondominant parietal lobe lesions
Definition
synthesizes spatial information into formed percepts (can't find their way around); topographical agnosia; apraxia (inovoluntary movement); spatial agnosia; dressing apraxia; unformed or semiformed visual hallunications
Term
dorsal stream: "where it is"
Definition
can't anticipate movement (looks like series of snapshots)
Term
perseveration
Definition
keep doing something over and over again
Term
occipital lobe lesions
Definition
defects tend to be vascular or traumatic (very sensitive to anoxia); supplied by two poserior cerebral arteries; macula supplied by middle cerebral artery
Term
the blood supply to optic radiation is important why?
Definition
macular sparing VF because it has a second blood supply
Term
neurological defects from occipital lobe pathology
Definition
usually neurologically silent; epileptic attacks; mild mental abnormalities
Term
LOOK AT MNEMONIC FOR CRANIAL NERVERS
Definition
LOOK AT CRANIAL NERVES MNEMOICN
Term
which 2 nerves don't have nucleus in brainsttem
Definition
olfactory and optic
Term
which nerves are sensory, motor, or both
Definition
"Some Say Marry Money But My Brother Says 'Bad Business Marrying Money'"
Term
supranuclear
Definition
premotor afferent neural pathways from the cerebral hemispeheres and cerebellum (send signal to nucleus of cranial nerve and say it wants to do something)
Term
nuclear
Definition
the nucleus of the cranial nerve, most located in brainstem
Term
fascicle
Definition
portion of the "cranial nerve" from the nucleus until it exits the brainstem (from nucleus and starts to go out of brainstem)
Term
internuclear
Definition
pathways connecting nuclei (nucleus of diff nerves connect and can move muscles together)
Term
infranuclear disorder
Definition
damage to the nerve in brainstem (fascicle) or after it exits teh brainstem (cranial nerve)
Term
olfactory nerve (I)
Definition
basal cells in basement membrane produce new receptor cells; only aread of CNS that continuosly regenreates cells (60 day turnover)
Term
what is the primary olfactory area and what structures does it contain
Definition
rhinencephalon; olfactory association area, hypothalamus, thalamus, orbitofrontal cortex
Term
what is involved when you smell something and it brings you back to a certain time and place
Definition
hypothalamus
Term
what is the only sensory nerve that has primary sensory neurons in epithelium as receptors
Definition
olfactory
Term
problems with olfactory N
Definition
difficulty smelling; diminished taste of food (ageusia)
Term
what could pathology be for olfactory N problem
Definition
cold/allergy (receptro); viral (flu, herpes simplex, hepatitis) (receptor); trauma (shearing olfactory axons- cribriform plate) (primary axon), neoplams
Term
anosmia
Definition
inability to perceive odors
Term
what is foster-kennedy syndrome
Definition
contellation of findings associated with tumors in frontal lobe: optic atrophy (ipsilateral eye); papilledema (contralateral eye); CNI or CNII compression; anosmia (ipsilateral)
Term
olfactory N optometric concerns
Definition
ON compression (cuz so close to each other); possible eye movement anomalies (front lobe is big player in eye movements)
Term
how do you measure APD?
Definition
hold neutral density filter in front of good eye; want to equalize eyes
Term
optic nerve optometric concerns
Definition
decreased VA, decreased VF, APD
Term
how far back in the brain does the oculomtor nerve start
Definition
2/3 of the way back
Term
__ N palsy presents most devasting pciture of any EOM palsy
Definition
3rd
Term
what will eyes look like with 3rd nerve plasy
Definition
eye won't go up, down, in; ptosis; pupil dilated; often intorsion
Term
what blood vessel is ruperior to CN 3 and can cause problems
Definition
posterior communicating artery
Term
what should you worry about in congential CN 3 palsy
Definition
about ptosis blocking visual axis and creating amblyopia
Term
besides the posterior communitating artery, which other BV can cause problems for the 3rd CN
Definition
basilar artery
Term
what two factors are involved with 3rd nerve problems
Definition
accommodation and convergence
Term
what is an early sign of problem with cn 3
Definition
problem with convergence
Term
where does the 3rd N divide into sup and inf portions
Definition
cavernous sinus
Term
whent the 3rd N enters the orbit, where do the sup and inf divisions go
Definition
sup: SR and levator
inf: everything else
Term
the pupil is rarely spared in ___ is cause of sudden 3 N palsy
Definition
aneurysm
Term
pupil is usually affected with ____ but not ___ in 3 N
Definition
compression; microvascular probelsm
Term
aberrant regeneration
Definition
break twigs off nerve and needs to be connected to something; can connect to stuff it's not supposed to
Term
causes of aberrant regeneration
Definition
congenital, trauma, neoplasm, aneurysm
Term
optometric concerns with 3 N
Definition
efferent anomalies (pupil is larger), 4 of 6 EOMS affected, diplopia, torsion possible
Term
trochlear N palsy causes
Definition
head trauma, congenital, ischemic neuropathy, pressure from vascular disease or hydrocephalus
Term
what happens with superior oblique palsy
Definition
diplopia in downgaze, and one horiztonal direction; head tilt; large vertical fusion amplitudes; history of intermittent diplopia when tired
Term
what is the course of the trochlear n like
Definition
goes around whole outside of brainstem; very long course
Term
aneurysms affect the __ N more than the ___, bubt less than the ___
Definition
4; 6; 3
Term
congenital ___ N palsies are common? they share most frequent cause with ___
Definition
4; trauma
Term
damage the the 4 N will create problems with what EOM
Definition
superior oblique
Term
when patient has a problem with an EOM or nerve,how will they tilt their head
Definition
will tilt head to side that is opposite of bad muscle
Term
when a ptient comes in witha head tilt, what 2 things can you assume
Definition
1) palsy of nerve/muscle opposite of turn
2) tilt head cuz they're fusing
Term
torticollis
Definition
tilting of head
Term
what is a "FAT" scan
Definition
Family Albuum Topogprahy: look at old pics to see if head tilt is recent or old
Term
optometric concerns with 4 nerve problems
Definition
vertical dipolopa, torsion, note head tilt
Term
trigeminal nerve components
Definition
contains largest sensroy glangion in skull; both motor and sensory; motor nucleus is small, round and in pons; sensory nucleus is long, pons into medulla to spine
Term
what are the 3 branches of trigeminal N
Definition
V1: ophthalmic, V2: maxillary, V3: mandibular
Term
3 major branches of ophthalmic division and what do they do
Definition
frontal n (medial upper eyelid, medial forehead); lacrimal n (lateral upper eyelid, conjuctiva, lacrimal gland); nasociliary n (medial eyelid, side of nose, ethmoid, ciliary nerves (afferent corneal reflex)
Term
how to test corneal reflex (nasociliary nerve)
Definition
have pt look up slightly, bring floss in to touch lower cornea, switch ends for other eye
Term
what is the blink reflex pathway
Definition
nasociliary n to midbrain to facial nerve to eyelid
Term
blink reflex is a relationship between what 2 nerves
Definition
5 and 7
Term
maxillary n (part of trigeminal)
Definition
zygomatic, infraorbital, superior alveolar, palatine nerves; upper teeth, hard palate, nasopharynx, nasopalatine nerve
Term
mandibular (branch off trigeminal)
Definition
buccal, lingual, inferior alveolar, auriculotemporal; lower jaw, teeth, gums, anterior 2/3 tongue, invovled in chewing
Term
referred pain can deal with what nerve
Definition
5
Term
V1 and V2 of trigeminal go where, and V3 goes where?
Definition
through lower cavernous sinus; below cavernous sinus
Term
all divisions of trigeminal nerve join where
Definition
trigeminal ganglion
Term
what 3 things can the divisions of trig nerve be tested for
Definition
proprioception, light touch/vibation, pain
Term
trigeminal neuralgia (tic douloureux)
Definition
severe, sharp, stabbing pain; often triggered by a specific stimuli; pain lasts less than 2 minutes
Term
organization of V N receptors rostral to caudal
Definition
proprioceptive, light touch (vibration), pain (temp)
Term
optometric concerns with trigem n
Definition
afferent portion of corneal blink reflex
Term
6 N paired nuclei at what level
Definition
pons and 4th ventricle
Term
6 N contain 2 types of neurons
Definition
ipsilateral to LR and contralateral through MLF (medial longitudinal fasiculus) to MR
Term
nuclear lesion in 6 n causes
Definition
gaze palsy
Term
the 6 n fascicle gors through __ to __
Definition
tegmentum to pontomedullary junction
Term
MS or strokes cause prbolem in )___ n
Definition
6
Term
___ n palsies are most common ophthalmoplegia
Definition
6 N
Term
course of 6 n
Definition
comes out bottom of pons, to medulla, thourh petrous bone
Term
what ligamient tethers the 6 N down so when the head moves, it doesnt?
Definition
Gruber's ligament
Term
the 6 n is located right next to what blood vessel in cav sinus so if there is an aneruysm here, it will cause a problem
Definition
internal carotid
Term
what % of 6 n palsy due to trauma resolve completely
Definition
50%
Term
as the 6 n crosses ____, it's subject to trauma and inflammation
Definition
pterous bone
Term
if children are havingf probelm with hearing and eyesight, what nerve would you consider
Definition
6
Term
what nerve circles around the 6th
Definition
7th
Term
optometric concerns with 6 n
Definition
horizontal diplopia (usually worse in field of palsy), esotpropia, common post stroke and trauma
Term
what nerve is susceptible to alcohol and causes you to see double when you drink
Definition
6
Term
what are 4 components of the 7 N and what do they do
Definition
1) somatic (brachial) motor: in pons- grows around VI nuclei. closes lid, moves lips, facial expressions, efferent corneal reflex
2) visceral motor: superior salivatory nucleus. lacrimates and salivates (parasympathetic)
3) somatic sensory: minor- around ear
4) visceral sensroy: anterior 2/3 tongue, pharynx, taste buds. touch, pain, pressure. nucleus solitarius
Term
what are the 2 grouped nucleir and are they sensory or motor? what evaluation are they important with
Definition
solitarius (sensory), ambigus (motor); importnat with vertigo evaluation
Term
if someone has trouble with vertigo, taste, swallowing, speech... where should you suspect a problem?
Definition
brain stem
Term
how do you test the 7 nerve
Definition
ask them to smile, wrinkle nose, and lift eyebrows
Term
upper motor nerve of 7 N goes to ___ and lower motor nerve of 7 N goes to ___.
Definition
upper: bilateral to forehead, contra to lower
lower: ipsi upper and lower
Term
if you have 1/2 your whole face involved in a 7 N damage, you would sustepect upper or lower damage
Definition
lower
Term
lid innervation are by what 2 nerves and what do they do
Definition
CN 7: (looks like a hook) and closes the lid (if damage, the lid can't close)
CN 3: (looks like pilars) and holds eye open (damage will cause ptosis)
Term
what is bell's reflex and why is it important
Definition
try to blink and eyes role up and cornea goes up in diff position (wipe cornea when blink to clean cornea and for protection)
Term
Bell's palsy
Definition
ipsilateral facial palsy (peripheral); from cold temp, virus, idiopathtic, trauma; unable to wrinkle brow, nose, smile, weak lid closure; flattened nasolabial fold; difficulty in puffing out cheeks; problem with lower neuron of 7th nereve; 80% recovery in 2 months
Term
when multiple nerve palsies, which 2 areas should you think about
Definition
cavernous sinus and brainstem
Term
optometric concerns with 7 n problem
Definition
controls lid closure (corneal exposure if not compensated); discomfort, ulcers, and treatment issues
Term
what nerve is responsible for hearing and balance
Definition
8- vestibulocochlear
Term
8 n is a two part sensory nerve that consists of:
Definition
vestibular: info on head position and movement
cochlear: info on hearing
Term
what nuclei coordinates motor activities involved in eye and skeletal movements
Definition
vestibular nuclei
Term
what are 2 types of vestibular dysfunction and what do they consist of
Definition
1) peripheral (outside central area of brain): recurring periods of vertigo (whole world moving around), always nystagmus
2) central (usually vascular or tumor): damage to vestibular nuclei or connections, milder symptoms than peripheral
Term
common peripheral diagnsoses
Definition
benign paroxysmal postional vertigo (BPPV), labyrinthitis, meniere's disease
Term
Benign Paroxysmal Positional Vertigo
Definition
true vertigo, always positional (lying down, rolling over, getting up, bending over, looking up... short duration- only lasts for a few seconds); no associated hearing loss (only vestibular); head trauma, post labyrinthitis, elderly; psotive Hallpike maneuver
Term
BPPV treatment
Definition
time; particle repositioning maneuvers; cawthorne (habituation) exerices; occassionally medication; rarely surgery; rarely disabling
Term
Epley maneuver
Definition
get rid of BPPV by head maneuver
Term
labyrinthitis
Definition
sudden onset, severe tru vertigo, nausea, difficulty walking, motion sensitivity; absence of auditory symptoms; severe symptoms 1-3 days; gradual resolution, days-weeks; chronis symptoms in 10%; longer lasting, not position dependent; problems walking
Term
labyrinthitis treatment
Definition
acute phase: reassurance, vestibular suppressants, steroids, anti-emetics
subacute pahse: discontinue meds, activity
chronic phase: exercies, PT (get ppl used to dealing with it)
Term
meniere's disease
Definition
episodic vertigo, hearing loss, tinnitus (ringing in ear), aural fullness (feel like something stuffed in ear); no other identifiable causes; usually unilateral, 10% bilateral; no gender/age preference (adults); unassociated with other health conditions
Term
meiere's disease vertigo and hearing loss
Definition
vertigo: attacks, sudden onset, no pattern or positional provocation, 30 min - several hours, generally normal between events
hearing loss: low or all frequencies, fluctuating, rarely gradual, paradoxical noise sensitivity (don't expect it to happen, have hearing loss but very sensitive to sound), distortion; may last longer
Term
meniere's disease tinnitus and aural fullness
Definition
tinnitus: fluctuating, often low pitched, roaring, may correlate with attacks
aural fullness: fluctuating plugged senesation, may correlate with other auditory symptoms
Term
meniere's disease treatments
Definition
low sodium diet; diuretics; vestibular suppressants (not as sensitive... benzodiazepines); gentamic injections (AB but 8 N is very senstive to damage by is so would sacrifice hearing to get rid of diziness); surgery (shunt 8 n section, labyrinthectomy)
Term
acoustic neuromas are what? what nerves do they affect?
Definition
slow growing tumor pressing on area of brainstem (pons). will affect 5, 6, 7, 8
Term
sensory organization deficit
Definition
mild, moderate or severe head injury; disruption of central processing of visual, vestibular and proprioceptive input; chronic dyequilibrium (no spinning); visual sensitivity: loss, stimulation, conflict; vestibular PT; prognosis varies with severity of trauma; safety/work issues
Term
optometric concernes with 8 nerve
Definition
nystagmus; oscillopsia (what patient expereinces... moving world); equillibrium (puts greater responsibilty on bioncularity); common follwoing head trauma
Term
glossopharyngeal sensory and motor
Definition
sensory: from soft palate and pharynx; also chemoreceptors in posterior tongue; afferent gag reflex
motor: pharyngeal muscle and parotid salviary gland
Term
barorecptors and chemoreptors are associated with what nerve
Definition
9
Term
vagus nerve
Definition
long and largest visceral sensory nerve; goes through thorax and abdomen (brainstem to colon); afferent and efferent innervation (larynx, pharynx, viscera; visceral afferents (inferior nucleus); mtoro fibers (nucleus ambigusus and dorsal efferent); parasympathetic fibers to: larynx, pharynx, trachea, lungs, hear, GI tract, pancreas, gallbladder, liver; test motor function efferent gag reflex; damage may cause hoarsness *larynx) and difficulty with the "kuh" sound (soft palate)
Term
vagus visceral problems
Definition
decrease HR, constrict bronchi, affect speech, increase difestive activity
Term
optometric concerns with vagus nerve
Definition
vaso-vagal response (patient passing out when eye is touched)
Term
accessory spinal nerve
Definition
motor nerve; trapezius and sternocleidomastoid; direct portion: sterno portion; longer portion: trapezius portion
Term
lesions of CN XI
Definition
complete lesion: ipsilateral paralysis; upper motor lesion: hypertonic (things might be clenched up)
Term
2 pathways for CN 11
Definition
1) R cortex to R lower motor neuron to ipsi sternomastoid which elevates chine and turns head to left
2) right cortex to left lower motor neuron to contralateral trapezius muscle which elevates left shoulder
Term
check CN 11
Definition
push on side of head to see if they can ressit force; see if they can shrug their shoulders
Term
12 n and carotid
Definition
motor: ipsilateral muscles of tongue; both voluntary and reflexive circuits (want to stick tongure out and gag)
Term
lower motor neuron lesion of 12 n, what will happen to tongue
Definition
deviate to same side
Term
12 n dysfunction
Definition
hypoglossal defect causes problem trying to say "la" (tongue coordination and tongue deviation)
Term
optometric concerns with 12 n
Definition
carotid dissection can cause pupillary anomalies (efferent)
Term
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Definition
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