1) UMN call body are in the motor cortex--> send axon down through the internal capsule

2) Through the brain stem from the pyramids on the medulla

3) lower medulla- 80% UMN cross over the midline to form lateral corticospinal tract in the lateral white matter

4) most remaining uncrossed fibers tract down the anterior corticospinal tract in the spinal cord

Disorder of transmission at the neuromuscular junction that effects communication with motor neuron and muscle cell

Autoimmune disease caused by an antibody mediated destruction of acetylcholine receptors in the neuromuscular junction r/t abnormal T-lymphocytes function generally associated with Thymus or Thymic hyperplasia

Acts on post-synaptic membrane of motor end- plate perventing depolarization

Muscle relaxtion

Inhibit ACE and cause accumulation of acetylcholine

Used in Myasthenia Graves

 Blocks release of acetylcholine

-Paralysis

-Used with spasmodic tortillas

 Bined ACE to prevent the break down of acetylcholine

Excessive and prolonged acetylcholine action with depolarization block of cholirergic receptors

 Acute immune- mediated polyneuropathy due to immune mechanism with motor sensory or autonomic manifestation

Linked with C. jejyni, CMV, EBV, infection

inherited forms of Parkason

mutation of a-synuckin and parkinsons genes

Additional causes of parkinsons

post encephalitic syndrom anti psychotic drugs

Phenothiazines

CVA, tumors, repeated head trauma

Truncal Ataxia

inability to maintain a steady posture

Nystagmus

Inability of eye to fix on target

Amyotrophic lacteral sclerosis

(lou Gehrig disease)

Degeneration and death of LMN in ventral horn

Umn in CC, motor nuceli of brain stem

intellegence and sensory stays

55-60 y/o males

Progressive disease- survival 2-5 years onset symptoms

MS

Multiple sclerosis

A demyelonating disease of the CNS

patho: Demyelination and subsequent degeneration of Nerve fibers in teh CNS resulting in conduction abnormalaties from decreased conduction velocity to conduction blocks

Anterior Cord Syndrome

damage to anterior section of cord

damage to anterior spinal arterior causing infarction of anterior 2/3 of cord

Loss of motor function- damage to cortisospinal tracts

Fine touch and proprioception stays intact

brown- sequard Syndrome

Damage to one hemisection of the cord motor function loss on same side

Pain and temperature sensation lost from contralateral side

Injury to central gray/ white matter- occurs in cervical cord

Arms more affected that legs