Term
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Definition
thin processes sprouting from an immature neuron
one will become an axon with accelerated growth
others become dendrites (receive info from other axons) |
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Term
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Definition
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Term
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Definition
microtuble-associated proteins
regulate mt initiation, polymerization, and stability |
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Term
| support cell cortex and produce dynamic cortical motility |
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Definition
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Term
| structure of motor protein moving cargo |
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Definition
| [image]protein filament and/or cargo canr resist movement |
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Term
actin, myosin, microtubule, dynein, kinesin
(match motor to filament and give direction) |
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Definition
actin-myosin, +/-
microtubule-dynein, -
microtuble-kinesin, + |
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Term
| first critical step of neurite initiation |
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Definition
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Term
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Definition
localized tension that pulls out the cell cortex
(can be from internal or external)[image] |
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Term
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Definition
ABPs at filopodia tips
promote actin polymerization-->axon
therefor, filopodia can induce neurite formation
external pulling |
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Term
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Definition
| slides MTs outward, pushes out |
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Term
| neurite growth process via MTs |
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Definition
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Term
| Where does new MT elongation occur? |
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Definition
| distal tip, in growth cone area |
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Term
| pattern of membrane expansion with neurite growth |
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Definition
| subunits add in throughout membrane[image] |
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Term
| growth cone membrane expansion mechanism |
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Definition
| exocytosis (reversible by endocytosis) |
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Term
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Definition
| myosin II: compressive, will collaps and retract neurite if there are no adhisive forces to combat the compressive ones |
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Term
| neuron-substrate adhesion receptor types |
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Definition
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Term
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Definition
| help F-actin link to N-cadherin |
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Term
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Definition
| link actin with ankyrin, spectrin, and FERM protein domains |
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Term
| main growth cone structure |
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Definition
| actin, MTs, vesicular cargo transported on MTs |
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Term
How does growth cone motion help neurite elongation?
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Definition
- form substrate adhesions that stabilize the axon
- protrusions make space for more MTs, etc.
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Term
| neuronal polarization stages |
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Definition
- lamellipodia formation
- neurite formation
- one neurite accelerates growth and becomes axon (typically the first neurite formed-->orientation of centrosome? environmental conditions?)
- - 5. elongation, synapse formation
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Term
| neocortex axon and apical dendrite |
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Definition
axon: from trailing process
apical dendrite:
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Term
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Definition
dendrite: all MTs + end distal
axon: MTs run in both directions |
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