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NEU Genetics Vollmer Fall 2010 Lec 6 & 7
These flashcards cover important lecture material from lectures 6 and 7
19
Microbiology
Undergraduate 1
09/26/2010

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Cards

Term
What is important to know about DNA and what 2 variations are there?
Definition

DNA is a single molecule of DNA and there is both linear and circular DNA. Eukaryotes tend to have linear DNA with a lot of "junk" DNA which is mostly useless but most prokaryotes have linear DNA in which all (or nearly all) DNA is useful and codes for functioning proteins

Term
What is an interested fact regarding mitochondria and chloroplasts?
Definition

Studies of both mitochondria and chloroplasts have revealed DNA segments within them. This suggests that there was a fusion between early cells in order to maximize efficiency. Since most eukaryotic cells contain mitochondria but not all cells contain chloroplasts it is believed that mitochondria fused first, then chloroplasts

Term
What is chromatin?
Definition

Chromatin is a complex aggregation of DNA and protein which forms the basic structure of eukaryotic chromosomes

Term
What are histones?
Definition

Histones are small, typically circular proteins which are made up of 20-30% arginine or lysine. This property makes them positively charged so that they can bond to open negatively charged bonding sites on DNA

Term
How are chromatin fibers further organized within the nucleus?
Definition

They're organized into zones and territories within the nucleus. There are zones for each chromosome and suh forth

Term
What do chromosome territories within the nucleus mostly depend on?
Definition

Gene densities

Term
Why are metaphase chromosomes very condensed?
Definition

It's necessary for them to be condensed in order to move the genetic material somewhat quickly and in an orderly fashion

Term
What is heterochromatin?
Definition

Heterochromatin is very dense chromatin which has very little coding segments within it

Term
What is euchromatin?
Definition
Euchromatin is loser chromatin which has a much high coding density than heterochromatin
Term
What is so special about telomerase and why is it so important?
Definition

Telomerase contains its own RNA which guides the chromosomal DNA to produce more telomere repeats. This is important because when DNA is read there is often some section of DNA that gets physically cut off from the end; the telomeres act as the sort of sacrificial volunteers for this side effect

Term
What was interesting about early research on insects in regards to sex determination?
Definition

Female individuals were found to have 2 X chromosomes but males to only have one

Term
What is the most common form of sex determinism?
Definition

Sex is typically determined by the X and Y chromosomes. This occurs in all mammals and also within most other animals

Term
What did Morgan's fruit fly experiments show?
Definition

It showed that eye color in flies was actually sex linked. Males had a much higher chance of having white eyes (recessive)

Term
What is nondisjunction?
Definition

Nondisjunction happens when chromosomes fail to seperate during meiosis and an entire chromosome is either lost or gained. These kinds of conditions are known as trisomies or monosomies, most notable trisomy 21 (Down Syndrome), trisomy 18 (Edward's Syndrome) and trisomy 13 (Patau's Syndrome). T13 and T18 are typically fatal within 3 months of birth or result in miscarraiges

Term
Let's say that a couple has 9 kids. Set up the formula to determine the chances of them having all girls and also the formula to determine the chances of them having at least one boy
Definition

Girls: (1/2)9. At least one boy: 1-(1/2)9

Term
What is the equation that you can use when you want to find out the chances of a fraction probability with whole number amounts of individuals?
Definition

(n!/s!t!)psqt (n = total number of individuals, s = amount of individuals with a specific characteristic, t = n-s, p = fractional probability of s occuring, q =  fractional probability of t occuring

Term
What is a goodness of fit test?
Definition

It's a test that analyses whether or not the observed data matches expectations

Term
What does chi squared represent?
Definition
It represents the sigma notation form of (Observed-Expected)2/Expected
Term
What does P stand for in relationship to chi squared problems and when does this value become important?
Definition

P stands for probability. When the P value goes above .05 (meaning there is a bad fit more than 5% of the time) it becomes statistically significant

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