Term
What are multifactorial/complex traits? |
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Definition
Multifactorial/complex traits are traits which don't exhibit simple Mendelian genetic inheritance. Instead, they exhibit complex genetic interpretation and depend on several different alleles for their genotype |
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Term
What are continuous traits? |
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Definition
Continuous traits are genetic traits that vary continuous (basically remain the same) from one phenotypic extreme to the other. Examples include height, blood pressure and corn yield. These traits are usally reflective of the genotype/phenotype of the individual's parents |
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Term
What are categorical traits? |
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Definition
Categorical traits are traits in which the phenotype falls into a discrete category. Examples include the number of eggs laid and the number of pups in a litter. These traits are typically stable but can vary depending on conditions and simple random chance |
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Term
What are threshold traits? |
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Definition
Threshold traits are traits that usually have two phenotypic categories but inheritance is determined by effects of multiple genes and environmental factors. Examples include the likelihood of having twins and the likelihood of developing breast cancer |
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Term
Why can most quantitative traits not be studied by the usual pedigree methods? |
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Definition
1. Effects of one gene can be masked by effects of other genes and these two genes will probably segregate independently. 2. Environmental effects can cause individuals with identical genotypes to have different phenotypes |
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Term
What is the distribution of a trait in regards to the population? |
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Definition
The distribution is a description of the population in terms of the proportion of individuals that have each of the possible phenotypes. Variation within this can be entirely genetic, environmental or a combination of both |
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Term
When looking at a chart, where does the mean occur? |
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Definition
The mean occurs right at the peak of the distribution. If there is no set peak then you add up all of the numbers and divide by the total amount of numbers present |
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Term
How do you calculate the variance given data from a chart? |
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Definition
Variance is given by squaring the mean minus the x value of interest and summing all of these values up and then dividing by the total amount of samples minus one (sigma2=(E(x-xi)2)/N-1 |
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Term
How do you find the standard deviation? |
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Definition
The standard deviation is the sqaure root of the variance. A bell curve is called a normal distribution |
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Term
How can variation in a trait be separated and what do each of these represent? |
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Definition
Variation can be separated into genetic and environmental components. Genotypic variance (represented by sigmag2) is the variation in phenotype caused by difference in genotype and environmental variance (represented by sigmae2) is the variation in phenotype caused by the environment |
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Term
When does the total variance in the population equal the sum of the genotypic and environmental variance? |
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Definition
It will happen when the genetic and environmental effects contribute independently to the phenotype |
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Term
What is genotype-environmental interaction? |
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Definition
Genotype-environment interaction means that environmental effects on the phenotype differ according to genotype |
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Term
What is genotype-by-sex interaction? |
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Definition
This type of interaction is where the same genotype produces different phenotypes in males and females (for example, height distribution) |
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Term
What happens to phenotypic variation when individuals are genetically homogenous (the same)? |
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Definition
The phenotypic variation becomes equal to the environmental variance. The same applies applies for when an environment is the exact same except that phenotypic variation is now only due to genotypic variation |
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Term
How could you calculate the genotypic variation in an F2 generation when you know that all individuals in the F1 generation are genetically homogenous? |
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Definition
You can calculate the genotype variance using the phenotypic variance of the F2 generation and the environmental variance of the F1 generation |
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Term
What is broad-sense heritability (H2)? |
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Definition
Broad sense heritability is the ratio of genetic variation to phenotypic variation. It can be calculated by using sigmag2/sigmag2. When H squared=1 then the variation is all genetic and when H squared=0 the variation is all environmental |
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Term
How can you assess things like genotypic, phenotypic and environmental variability using twin studies? |
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Definition
Since identical twins have a genotypic variability of 0 and fraternal twins have a genotypic variability of 1/2 that of regular people you know that the overall genotypic variability will equal twice (the phenotypic variability of fraternal twins plus the genotypic variability of identical twins) |
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Term
Why do twin studies tend to over-estimate the genetic contribution to variance? |
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Definition
They tend to over-estimate this figure because environment experienced by twins is usually very similar |
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Term
What is artificial selection? |
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Definition
Artificial selection is managed evolution. A select group of individuals is selected from a population to become parents of the next generation |
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Term
What is narrow-sense heritability (h2) and how can it be calculated? |
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Definition
NSH is the proportion of phenotypic variance transmissible from parents to offspring. The formula is h2=(M'-M)(M*-M) |
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Term
What is correlated response in regards to artificial selection? |
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Definition
Correlated response is the effect of selection for one trait on a non-selected trait. This means that although one trait is being optimized another might be negatively impacted by this sort of forced selection |
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Term
What is inbreeding depression? |
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Definition
Inbreeding depression is a decrease in fitness due to harmful recessive alleles which become homozygous over time |
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Term
What is a quantitative trait locus? |
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Definition
A QTL is a gene that affects a multifactorial quantitative trait. These traits are mapped genetically by checking for DNA polymorphisms that are closely linked to the trait of interest |
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Term
What is a candidate gene in regards to a quantitative trait locus? |
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Definition
A candidate gene is a gene that researches make an educated guess that genetic variation within that gene might affect a certain trait |
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