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NEU Genetics Fall 2010 Lec 29
These flaschards cover most slide and lecture material from Vollmer's Fall 2010 genetics section lecture #29
24
Microbiology
Undergraduate 1
12/09/2010

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Term
What are multifactorial/complex traits?
Definition

Multifactorial/complex traits are traits which don't exhibit simple Mendelian genetic inheritance. Instead, they exhibit complex genetic interpretation and depend on several different alleles for their genotype

Term
What are continuous traits?
Definition

Continuous traits are genetic traits that vary continuous (basically remain the same) from one phenotypic extreme to the other. Examples include height, blood pressure and corn yield. These traits are usally reflective of the genotype/phenotype of the individual's parents

Term
What are categorical traits?
Definition

Categorical traits are traits in which the phenotype falls into a discrete category. Examples include the number of eggs laid and the number of pups in a litter. These traits are typically stable but can vary depending on conditions and simple random chance

Term
What are threshold traits?
Definition

Threshold traits are traits that usually have two phenotypic categories but inheritance is determined by effects of multiple genes and environmental factors. Examples include the likelihood of having twins and the likelihood of developing breast cancer

Term
Why can most quantitative traits not be studied by the usual pedigree methods?
Definition

1. Effects of one gene can be masked by effects of other genes and these two genes will probably segregate independently. 2. Environmental effects can cause individuals with identical genotypes to have different phenotypes

Term
What is the distribution of a trait in regards to the population?
Definition

The distribution is a description of the population in terms of the proportion of individuals that have each of the possible phenotypes. Variation within this can be entirely genetic, environmental or a combination of both

Term
When looking at a chart, where does the mean occur?
Definition

The mean occurs right at the peak of the distribution. If there is no set peak then you add up all of the numbers and divide by the total amount of numbers present

Term
How do you calculate the variance given data from a chart?
Definition

Variance is given by squaring the mean minus the x value of interest and summing all of these values up and then dividing by the total amount of samples minus one (sigma2=(E(x-xi)2)/N-1

Term
How do you find the standard deviation?
Definition

The standard deviation is the sqaure root of the variance. A bell curve is called a normal distribution

Term
How can variation in a trait be separated and what do each of these represent?
Definition

Variation can be separated into genetic and environmental components. Genotypic variance (represented by sigmag2) is the variation in phenotype caused by difference in genotype and environmental variance (represented by sigmae2) is the variation in phenotype caused by the environment

Term
When does the total variance in the population equal the sum of the genotypic and environmental variance?
Definition

It will happen when the genetic and environmental effects contribute independently to the phenotype

Term
What is genotype-environmental interaction?
Definition

Genotype-environment interaction means that environmental effects on the phenotype differ according to genotype

Term
What is genotype-by-sex interaction?
Definition

This type of interaction is where the same genotype produces different phenotypes in males and females (for example, height distribution)

Term
What happens to phenotypic variation when individuals are genetically homogenous (the same)?
Definition

The phenotypic variation becomes equal to the environmental variance. The same applies applies for when an environment is the exact same except that phenotypic variation is now only due to genotypic variation

Term
How could you calculate the genotypic variation in an F2 generation when you know that all individuals in the F1 generation are genetically homogenous?
Definition

You can calculate the genotype variance using the phenotypic variance of the F2 generation and the environmental variance of the F1 generation

Term
What is broad-sense heritability (H2)?
Definition

Broad sense heritability is the ratio of genetic variation to phenotypic variation. It can be calculated by using sigmag2/sigmag2. When H squared=1 then the variation is all genetic and when H squared=0 the variation is all environmental

Term
How can you assess things like genotypic, phenotypic and environmental variability using twin studies?
Definition

Since identical twins have a genotypic variability of 0 and fraternal twins have a genotypic variability of 1/2 that of regular people you know that the overall genotypic variability will equal twice (the phenotypic variability of fraternal twins plus the genotypic variability of identical twins)

Term
Why do twin studies tend to over-estimate the genetic contribution to variance?
Definition

They tend to over-estimate this figure because environment experienced by twins is usually very similar

Term
What is artificial selection?
Definition

Artificial selection is managed evolution. A select group of individuals is selected from a population to become parents of the next generation

Term
What is narrow-sense heritability (h2) and how can it be calculated?
Definition

NSH is the proportion of phenotypic variance transmissible from parents to offspring. The formula is h2=(M'-M)(M*-M)

Term
What is correlated response in regards to artificial selection?
Definition

Correlated response is the effect of selection for one trait on a non-selected trait. This means that although one trait is being optimized another might be negatively impacted by this sort of forced selection

Term
What is inbreeding depression?
Definition

Inbreeding depression is a decrease in fitness due to harmful recessive alleles which become homozygous over time

Term
What is a quantitative trait locus?
Definition
A QTL is a gene that affects a multifactorial quantitative trait. These traits are mapped genetically by checking for DNA polymorphisms that are closely linked to the trait of interest
Term
What is a candidate gene in regards to a quantitative trait locus?
Definition

A candidate gene is a gene that researches make an educated guess that genetic variation within that gene might affect a certain trait

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