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Details

NEOPLASIA
N/A
43
Pathology
Graduate
10/22/2009

Additional Pathology Flashcards

 


 

Cards

Term
Aflatoxin/Alcohol/Hep B,C
Definition
Hepatocellular carcinoma
Term
Alkylating Agents
Definition
Leukemia, Lymphoma, others
Term
Aromatic – amines, azo-
Definition
Hepatocellular carcinoma
Term
Arsenic
Definition
Skin, Lung; Hemangiosarcoma of Liver
Term
Asbestos
Definition
Lung(MC), Mesothelioma(Rare)
Term
Benzene
Definition
Leukemia
Term
RADON/Chromium/Nickel/Berrylium
Definition
Bronchogenic CA
Term
Cigarette smoke
Definition
Larynx, oropharynx, Lung
Term
Ionizing Radiation
Definition
Thyroid Cancer, Leukemia
Term
Naphtylamine/Aniline Dye/Textile Rubber
Definition
Bladder Cancer
Term
Nitrosamine
Definition
Gastric, Esophagus cancer
Term
UV – B
Definition

Skin Cancers:

 

Basal Cell CA

Squamous Cell CA

Melanoma 

Term
Vinyl chloride/Plastic toys
Definition
Angiosarcoma of Liver
Term
SIS
Definition

Astrocytoma, Glioblastoma multiforme (PDGF, Overexpression)

 

 

 

 

Oncogene

Term
ERB B1
Definition

SCC Lung (EGFR, Amplification)

 

 

 

 

 

Oncogene

Term
ERB B2
Definition

Ductal of Breast (EGFR, Overexptression)

 

 

 

 

 

Oncogene

Term
ERB B3
Definition

Breast (EGFR, Overexpression)

 

 

 

 

 

Oncogene

Term
L-myc
Definition

Small Cell CA of LUNG (Nuclear regulations Protein AMPLIFIED)

 

 

 

 

Oncogene

Term
N-myc
Definition

Neuroblastoma (Nuclear regulatory Protein, Amplified)

 

 

 

 

Oncogene

Term
ABL-BCR
Definition

CML (9-22)

 

 

 

 

Signal transduction protein (TyrosineKinase)

Oncogene

Term
C-MYC
Definition

Burkitt Lymphoma (8-14)

 

 

 

 

 

Oncogene

Term
Bcl 1
Definition

Mantle cell Lymphoma (11-14)

 

 

 

 

 

Oncogene

Term
RAR-PML
Definition

AML-M3 (15-17)

 

 

 

 

 

Oncogene

Term
RET
Definition

MEN II,III, Thyroid CA (GNFR, Point Mutation)

 

 

 

 

 

Oncogene

Term
RAS
Definition

Lung, Pancreas, Colon (GTP binding; point mutation)

 

 

 

 

Oncogene

Term
RB
Definition

Retinoblastoma, Osteosarcoma

 

 

G1-- S block

Less PPP - bound to E2F

TSG

Term
APC
Definition

Familiar Adenomatous Poliposis/Colon

 

 

 

 

Block Nuclear Txn

TSG

Term
TGF-beta
Definition

Pancreas, Colon

 

 

 

 

G1 -- S block

TSG

Term
BRCA1/2
Definition

1 Breast, Ovary

2 Breast (prostate?)

 

 

 

DNA Repair

TSG

Term
BCL2
Definition

B cel Follicular Lymphoma (overexpresed)

 

 

 

T(14;18)

Apoptosis prevented

Term
Bax, Bad, Bid
Definition
Apoptosis promote
Term
p 53
Definition

Li- Fraumeni Syndrome Lung / Colon

 

 

 

G1--S block

 DNA Repair

TSG

Term

VHL

  

Von Hippel Lindau Syndrome

Definition

Cerebellar hemangioblastomas

Retinal angioma

Renal adenocarcinoma (bilateral) 

Pheochromocytoma (bilateral)

 

Nuclear Txn regulate

TSG

Term
PTEN
Definition

Endometrial Carcinoma

 

 

 

 

 

TSG

Term
NF 1
Definition

Neurofibromas

 

 

NF1 - GTPase Acting protein

via RAS

 

TSG

Term
NF2
Definition

Acustic neuroma, Bilateral Schwanoma

 

 

Merlin protein

 

 

TSG

 

 

Term

MSH2 / MLH1

 

Definition

Hereditary Non-Polyposis Colon Cancer Syndrome

HNPCC

 

 

 

 

DNA Repair

Term

Hepatitis B

 

Hep C

Definition
Hepatocellular Carcinoma
Term
Ebstein Barr Virus
Definition

EBNA

 

Burkitts Lymphoma

Hodgkin's Lymphoma

B cell Lymphoma in ImCompr

Nasopharyngeal Carcinoma

Term

HPV

 

 

Human Papiloma Virus

Definition

6, 11  Benign Squamous Papilloma (warts)

 

16, 18, 31  high risk Cervical Cancer

 

E6 - p53 (apoptosis inhibited)

E7 - Rb (growth, proliferation)

Term

Herpes

 

HHV 8

Definition
Kaposi Sarcoma
Term

HTLV1

 

Human T cell Leukemia Virus 1

Definition

T cell Leukemia, Lymphoma

 

Endemic Japan/ Caribbean basin

Term
H.Pylori
Definition

Gastric Lymphoma

MALT lymphoma

Marginal Zone Lymphoma

 

 

Gastric Carcinoma

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