Term
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Definition
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Term
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Definition
Normal
Dysplasia (cell change)
Cancer |
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Term
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Definition
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Term
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Definition
Malignant
-when a basement membrane is breached by cells |
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Term
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Definition
Hyperplasia
Metaplasia
Dysplasia
Neoplasia |
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Term
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Definition
neoplasitc cells
stroma and blood vessels
Other cells: Dendritic cells, lymphocytes |
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Term
| What is used to predict behaviour |
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Definition
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Term
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Definition
transformation
growth (proliferation < death)
invasion(cell grows and then spreads)
metastasis (spread from one location to another) |
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Term
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Definition
Somatic mutation theory
Tissue organization field theory |
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Term
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Definition
Genome instability
DNA mutation changes cell |
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Term
| Tissue organization field theory |
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Definition
Alteration in interactions among cells and between cells and their extra cellular matrix
-due to envrio |
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Term
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Definition
needs 30 divisions (1g)[doesn't need a blood supply]
-only 10 more division = 1 kg (catching it early doesn't help) |
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Term
Name based on Phenotype
Epithelial |
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Definition
Adenoma
Epithelioma
carcinoma |
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Term
Name base on Phenotype
Mesenchymal |
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Definition
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Term
Name base on phenotype
Round cell & other |
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Definition
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Term
| Effect of neoplasia on host |
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Definition
local effect (where it is grown) and hormonal effect(the whole body)
Cancer cachexia
paraneoplastic syndromes(group of clinical signs that have been felt)
Treatment |
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Term
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Definition
How long do you have to live
Determined by certain criteria |
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Term
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Definition
-Phenotype (what kind of neoplasm it is)
-Grade (determined by histological assessment of mass)
-Surgical Margins (end of surgical wound is studied)
-Stage (how far it has spread) |
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Term
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Definition
Based on Histological features
features of malignancy
-feature show it might spread
Growth rate
-cell cycle time
-percentage of proliferating cells
-amount of cell loss |
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Term
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Definition
-local invasion: has it invaded the cells around it?
-Vascular invasion: invaded blood vessels
-Lymph node Metastases: only to tell if spread - look in diff places
-Distant Metastases |
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Term
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Definition
Cytology (lymph nodes)
Histopathology (lymph nodes)
Medical imaging |
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Term
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Definition
Spread of neoplasm to a diff location from the original
Heamatogenous: having to do w/blood veseels
Lymphatic: spreads through the lymph nodes
mesothelioma: is one of the other ones
-malignant |
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Term
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Definition
-Surgery: debulk or excise
-Radiotherapy
Chemotherapy
-Immune Stimulation:
-Alternatives
-Targeted therapy |
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Term
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Definition
| trying to kill all rapidly dividing cells |
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Term
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Definition
| taking and culturing the neoplasis, and injecting them back into patients |
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Term
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Definition
| Just target the neoplasm tissue, w/o causing side effects |
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Term
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Definition
-DNA damage - mutation
-Tumour suppressor genes -control
-Oncogenes
-Defects in DNA repair |
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Term
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Definition
-cell cycle
-apoptosis
-DNA repair |
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Term
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Definition
being prominent in some neoplasms
-derived from proto-oncogenes |
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