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NBME
Cumulative Histology Exam
16
Histology
Professional
05/01/2011

Additional Histology Flashcards

 


 

Cards

Term
Muscle Connective Tissue Investments
Definition

Epimysium: surrounds entire muscle

 

Perimysium: surrounds fascicles of muscle cells

 

Endomysium: surrounds individual muscle cells (reticular fibers + external lamina)

Term
Red vs White muscle fibers
Definition

Red:
high in myglobin, mitochondria, oxidative enzymes

low in ATPase

 

White:

High in ATPase

use anaerobic glycolysis

Term
Desmin and Vimentin
Definition
intermediate filaments.
Desmin anchors Z disks to each other.
Vinculin anchors Z disks to sarcolemma
Term
skeletal muscle triads
Definition
formed by the sarcoplasmic reticulum at the A/I band junction
Term
Sacromere bands
Definition
A = thick + thin
I = thin H = thick
Term
Thin Filaments (muscle)
Definition
F-actin = G-actin polymers: bound by tropomyosin when relaxed and myosin during contraction
Term
Troponin
Definition
TnT = binds troponin to tropomyosin
TnC = Ca binding
TnI = actin binding (inhibit myosin bind)
Term
Thick Filaments
Definition
antiparalle myosin bundles with myomesin, titin, and C protein
Term
Myosin chains
Definition
Heavy = tail + head(w/ATPase)
Light = 2/head
Term
Myomesin
Definition
M line protein: cross link mysoins
Term
Titin
Definition
Anchors Z disk to thick filaments (myosin)
Term
Contraction regulation
Definition
DePol/Ca Release tavels down T tubules causing DHP opening = SR Ca release @ junctional feet. Ca binds troponin C = conf change and inhibition release + tropomyosin uncovers actin binding site.
Term
Motor Unit
Definition
a neuron and all the muscle cells it innervates (contract in unison).
Term
Junctional Folds
Definition
sarcolemmal ivaginations lined by external lamina (that contains acetylcholinesterase)
Term
muscle spindle
Definition
intrafusal fibers. stimulation (by strech or y-efferents) causes a-efferent firing = contract/shorten
Term
Golgi Tendon Organ
Definition
tension sensors: type Ib afferents inhibit a-efferents.
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