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1. _____ are large organic molecules made up of long twisted chains of amino acids. |
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2. _____ are the building blocks of life. |
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3. There are more than 100,000 different protein molecules in the body, and all of these diverse chemicals are built on only _____ amino. |
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4. A _____ is a compound characterized by the presence of an amine (NH2) and carboxyl (COOH) on the first alpha carbon atom. |
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5. A _____ amino acid is one that cannon be synthesized by the body. |
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6. Non-essential amino acids are manufactured in the _____. |
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7. 10 essential amino acids. |
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1) PHENYLALANINE, 2) VALINE, 3) THREONINE, 4) TRYPTOPHAN, 5) ISOLEUCINE, 6) METHIONINE, 7) HISTIDINE, 8) ARGININE, 9) LEUCINE, 10) LYSINE (PVT TIM HALL) |
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8. This essential amino acid is broken down into tyrosine, then L-dopa, then dopamine, then norepinephrine, then epinephrine. |
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9. This essential amino acid is broken down into serotonin and melatonin. |
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10. These 2 essential amino acids are essential only during periods of growth and pregnancy. |
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11. This essential amino acid is broken down into histamine. |
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12. This essential amino acid is broken down into creatinine and nitric acid. |
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13. This non-essential amino acid is used to manufacture thyroxin (T4). |
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14. This non-essential amino acid is broken down into porphyrin and then heme. |
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15. This non-essential amino acid is broken down into GABA and glutathione. |
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16. These 4 amino acids are derived from intermediates of glycolysis. |
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1) GLYCINE, 2) ALANINE, 3) SERINE, 4) CYSTEINE |
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17. Glycine is made from _____. |
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18. Alanine is made from the transamination of _____. |
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19. Serine is made from _____. |
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20. Cysteine is made from _____. |
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21. These 6 amino acids are derived from kreb’s cycle intermediates. |
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1) GLUTAMATE, 2) ASPARTATE, 3) GLUTAMINE, 4) ASPARAGINE, 5) PROLINE, 6) ARGININE |
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22. Glutamate is derived from _____. |
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23. Aspartate is derived from the transamination of _____. |
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24. Glutamine is derived from _____. |
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25. Asparagine is produced from _____. |
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26. Proline is derived from _____. |
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27. Arginine is derived from _____. |
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28. Proteins are made in the _____ where the genetic code is decoded via strands of mRNA. |
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29. This structure of proteins consists of a linear sequence of amino acids forming a polypeptide chain. |
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30. This structure of proteins is formed as the protein begins to fold with the chemical forces within the primary linear structure. |
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31. The secondary protein structure takes one of 2 forms which are either a _____ or a _____. |
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ALPHA-HELIX; BETA-PLEATER SHEET |
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32. The end product of secondary proteins is a 3-D structure stabilized by _____. |
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33. This structure of proteins controls the overall 3-D shape of a single protein molecule. It is the spatial relationship of secondary structures to one another. |
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34. The tertiary structure of a protein controls the basic _____ of the protein. |
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35. This structure of a protein is 2 or more tertiary structures put together. |
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36. _____ is a quaternary protein that contains 2 alpha, and 2 beta subunits. |
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37. There are 2 major groups of amino acids depending on their degradation products which are _____ and _____. |
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38. These 4 essential amino acids are glucogenic as they produce pyruvate and other intermediates in the krebs cycle which could be used to produce new glucose. |
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1) HISTIDINE, 2) METHIONINE, 3) THREONINE, 4) VALINE |
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39. These 2 amino acids are ketogenic as they produce ketone bodies such as acetyl CoA and acetoacetate which can be used as an alternative source in starvation and in diabetes mellitus. |
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40. These 3 essential amino acids are both ketogenic and glucogenic. |
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1) PHENYLALANINE, 2) ISOLEUCINE, 3) TRYPTOPHAN |
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41. All the non-essential amino acids are glucogenic except for _____ which is ketogenic. |
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42. When proteins are broken down, nitrogen is released and can be removed in these 4 manners. |
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Definition
1) TRANSAMINATION, 2) DEAMINATION, 3) AMMONIA FORMATION, 4 ) UREA FORMATION |
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43. _____ is a method of removing nitrogen in which NH2 is transferred from one molecule to another. |
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44. The 2 enzymes involved in transamination are _____and _____. |
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TRANSAMINASE AND AMINOTRANSFERASE |
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45. _____ is a process of nitrogen removal in which amino acids are broken down when too much protein has been taken in. |
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46. Deamination occurs in the _____. |
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47. in deamination, the _____ group is removed from the amino acid and converted to ammonia. |
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48. Deamination of glutamate produces _____. |
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49. Deamination of aspartate produces _____. |
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50. Deamination of alanine and serine produces _____. |
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51. _____ is a process of nitrogen removal when hydrogen is added to the NH2 group to form ammonia. |
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52. _____ is a process of nitrogen removal in which ammonia is converted into urea to be excreted in the urine. |
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53. _____ is toxic, especially to the CNS and must be removed from the body. |
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54. The urea cycle produces urea from _____, _____ and _____. |
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55. The main sources of nitrogen atoms are _____ and _____ which are degraded to ammonia. |
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56. The 1st step of the urea cycle involves converting ammonia to _____. |
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57. The 2nd step of the urea cycle involves carbamoyl phosphate reacting with _____ to form _____. |
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58. In the 3rd step of the urea cycle, citrulline passes out of the cytosol where it is combined with _____ to form _____. |
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ASPARTATE; ARGINONOSUCCINATE |
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59. In the 4th step of the urea cycle, arginosuccinate is split to form _____ and _____. |
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60. In the last step of the urea cycle, arginine is cleaved for form _____ and _____. |
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61. _____ is then transported back into the mitochondria where it can be used for another round of the cycle, while _____ is excreted in the urine. |
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62. What is the rate limiting step of the urea cycle? |
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CARBAMOYL PHOSPHATE SYNTHASE CONVERTING AMMONIA TO CARBAMOYL PHOSPHATE |
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