Term
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Definition
| Binds to catalytic site of reverse transcriptase and interferes with HIV viral RNA-dependent DNA polymerase, resulting in inhibition of viral replication. |
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Term
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Definition
Lactic acidosis and severe heapatomegaly with steatosis. Toxicities include peripheral neuropathy, pancreatitis, lipoatrophy, myopathy, anemia.
Mainly eliminated by the kidney. |
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Term
Abacavir + lamivudine
(Ziagen) + (Epzicom) |
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Definition
Must screen for HLA-B*5701 allele (increased hypersen rxn)
BB: hypersen rxn: fever , rash, CI upset |
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Term
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Definition
Abacavir + lumivudine
Didanosine
Emtricitabine
Lamivudine
Tenofovir + emtricitabine |
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Term
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Definition
pancreatitis
avoid combo with stavudine
Peripheral neuropathy |
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Term
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Definition
| May exacerbate HepB once drug is d/c |
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Term
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Definition
| Do not use Epivir-HBV for tx of HIV |
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Term
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Definition
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Term
| Tenofovir + emtricitabine BB |
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Definition
| May exacerbate Hep B once d/c |
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Term
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Definition
| Binds to reverse transcriptase and blocks the RNA-dependent and DNA-dependent DNA polymerase activities including HIV-1 replication |
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Term
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Definition
rash, most common with nevirapine, increased LFT's
Mainly cleared by liver |
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Term
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Definition
Delavirdine
Efavirenz
Etravirine
Nevirapine |
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Term
|
Definition
| inhibits HIV-1 protease and renders the enzyme incapable of cleaving the gag-pol plyprotens, resulting in the production of immature, noninfectious virions. |
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Term
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Definition
| hyperglycemia, insulin insensitivity, fat redistribution and lipodystrophy, increased bleeding with heophilia, hyperlipidemia, rare hypersensitivity rxs. Strong inhibitors of 3A4 |
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Term
|
Definition
Ataznavir
Darunavir
Ritonavir
Lopinavir + Ritonavir= Kaletra |
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Term
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Definition
Inhibit the fusion of the HIV-1 virus with the CD4 cells by blocking the conformational change in gp41
Enfurviritide |
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Term
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Definition
Binds to the CCR5 receptor on the CD4 cells nad prevents the conformational change required for cell entry
Maraviroc |
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Term
|
Definition
Inhibits the catalytic activity of HIV-1 integrase, thus preventing the insertion of HIV DNA into the host genome and virus cannot replicate
Raltegravir |
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Term
| Indications to initiate ART |
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Definition
History of AIDs-defining illness
CD4 count <350
pregnant
HIV-associated nephropathy
Coninfected with HBV when HBV treatment indicated |
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Term
| ART recgimens for treatment-naive HIV patients |
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Definition
NNRTI + 2NRTIs or
PI (prefer ritonavir) + 2NRTIs or
INSTI + 2NRTIs |
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Term
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Definition
Efavirenz+Tenofovir+Emtricitabine
Atazanavir+Ritonavir+Tenofovir+Emtricitabine
Darunavir+Ritonavir+Tenofovir+Emtricitabine
Raltegravir+Tenofovir+Emitricitabine |
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Term
| Preferred Pregnancy Regimen |
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Definition
| Lopinavir+Ritonavir+Zidovudine+Lamivudine |
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Term
|
Definition
history of AIDS-defining illness
or
CD4 <500
or
pregnant, HIV-nephropathy, HEP B |
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Term
Emtricitabine (Emtriva)
+efavirenz and tenofovir (Atripla) |
|
Definition
Atripla: tk on empty stomach hs
BB: exacerbates Hep B when dc
Hyperpigmentation of palms |
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Term
|
Definition
| BB: may exacerbate Hep B once dc |
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Term
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Definition
All can cause a rash
Increase LFT's
Mainly cleared by the liver |
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Term
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Definition
Tk on empty stomach hs
Preg D
strong inducer of 3A4 |
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Term
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Definition
| May prolong the PR interval, nephrolithiasis, hyperbilirubinemia |
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Term
|
Definition
Tk with food
Must be given with ritonavir
Caution with sulfa allergy |
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Term
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Definition
Tk with food
Store capsules in fridge
BB:interacts dangerously with other meds |
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Term
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Definition
Tk with food
Store capsules in fridge
BB:interacts dangerously with other meds |
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Term
| Lopinavir + Ritonavir (Kaletra) |
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Definition
solution tk with food
Fatal pancreatitis
Strong 3A4 inducer |
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Term
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Definition
| injection site rxns, pneumonia, hypersensitivity rxns |
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Term
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Definition
Med will not work with CXCR4-tropic disease
BB: hepatotoxicity
CI: 3A4 inhibitors or CrCl<30 |
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Term
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Definition
| Immune reconstitution syndrome, myopathy, increased CPK, rhabdo |
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