Nalaoxone

Classification:

Narcotic antagonist, Antidote

Action: 

Reverses respiratory and CNS effects of

certain narcotics by competing at opiate receptor sites.

Indications:

Known or suspected narcotic overdose with                                          respiratory depression (decreased tidal                                               volume or respiratory rate less than 12)

Contraindications: 

 Hypersensitivity

Adverse Effects:       

Cardiovascular

tachycardia              

dysrhythmias

hypertension                        

Gastrointestinal

nausea/vomit

Neurological

tremors                                                                  seizures

Administration:      

0.4 - 2 mg IV/IO/MADD.  Titrate to adequate respiratory rate and tidal volume. May repeat every 2 minutes to a max. of 10 mg

Pediatrics:               

< 5 years        0.01 mg/kg IV/IO/ MADD. Titrate to adequate respiratory rate and tidal volume.

> 5 years        same as adult dose

Onset:                       

Duration:                 

Onset:                         Immediate – 2 minutes

Duration:                   20-30 minutes

Precautions:  

Be prepared to administer additional doses if respiratory depression returns.

        Administer prior to intubation

Patients with narcotic dependency may experience signs and symptoms of withdrawal.