Term
| Myelodysplastic Syndromes (MDS) |
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Definition
Decrease in production of one or more cell lines
Prominent maturation abnormalities
aka Dysmyelopoietic Syndrome
Increased apoptosis
Usually occurs in males aged 60+
Present with weakness, fatigue, increased infections, and splenomegaly
Unresponsive to therapy
RBC's don't last as long
Retics don't work as well
Granulocytes have trouble with adhesion and chemotaxis |
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Term
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Definition
RBC's are dimorphic oval macrocytes
Basophilic Stippling
NRBC's
Howell-Jolly Bodies
Sideroblasts
Anisocytosis and Poikilocytosis
Retics
Neutropenia
Hypogranular WBC's
Pseudo-Pelger-Huets
Monocytosis
Low platelets
Giant, Hypogranular platelets |
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Term
| MDS Bone Marrow Biopsy and Aspirate Results |
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Definition
Hypercellular
Erythroid Hyperplasia |
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Term
| State of RBC's in the bone marrow |
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Definition
Megalobalstic
Nuclear Fragmentation
Defective Hemoglobinization
Vacuolization
Ringed Sideroblasts |
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Term
| State of WBC's in the bone marrow |
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Definition
Abnormal granules in the promyelocytes
No seconday granules
Nuclear abnormalities
Decreased myeloperoxidase
Auer rods in the blasts |
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Term
| State of the platelets in the bone marrow |
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Definition
Micromegakaryocytes
Megakaryocytes with multiple separated nucleoli
Hypogranulation or large abnormal granules |
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Term
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Definition
Iron is normal to increased
TIBC is normal to decreased
Folate is low to normal
T-lymphocytes are decreased |
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Term
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Definition
Broken down by:
-Percentage of bone marrow blasts
-Presence of ringed sideroblasts
-Percentage of monocytes
-The extent of cytopenia and the degree of dyspoiesis
Refractory Anemia
Refractory Anemia with Ringed Sideroblasts
Refractory Anemia with Excess Blasts
Refractory Anemia with Excess Blasts in Transformation |
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Term
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Definition
Refractory Anemia
Refractory Anemia with Ringed Sideroblasts
Refractory Anemia with Multilineage Dysplasia
Refractory Anemia with Excess Blasts
Myelodysplastic Syndrome with Isolated del(5q)
Myelodysplastic Syndrome, Unclassified |
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Term
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Definition
Hypoplastic MDS
MDS with Fibrosis
Unclassified
Therapy-Related Myelodysplasia
The 5q- Syndrome
Childhood MDS |
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