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Muscular system
MCAT
53
Other
Not Applicable
03/10/2005

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Term
Muscle tissue
Definition
Consists of bundles of specialized contractile fibers held together by connective tissue. Three types of muscles in mammals.
Term
Skeletal muscle
Definition
Responsible for volunatry movements. Innervated by the somatic nervous system.
Term
Skeletal muscle fibers
Definition
Each is a multinucleated cell created by the fusion of several mononucleate emryonic cells. Nuclei found at periphery of the cell.
Term
Skeletal muscle fibers
Definition
Each is a multinucleated cell created by the fusion of several mononucleate emryonic cells. Nuclei found at periphery of the cell.
Term
myofibrils
Definition
Filaments that are embeded in skeletal muscle fibers. Enveloped by a modified endoplasmic reticulum. Further divided into sarcomeres.
Term
Sarcomeres
Definition
Contractile units within myofibrils
Term
Sarcoplasmic reticulum
Definition
Modified endplasmic retriculum that stores calcium ions; envelops myofibrils.
Term
sarcoplasm
Definition
cytoplasm of a muscle fiber.
Term
sarcolemma
Definition
cell membrane of a muscle fiber. Capable of propagating an action potential, connected to the T system.
Term
transverse tubules (T system)
Definition
Oriented perpendicular to myofibrils. T system provides cahnnels for ion flow throughout the muslce fibers; can propogate action potentials.
Term
Red fibers (Skeletal muscle)
Definition
Slow-twitch fibers. Have a high myoglobin content, and mitochondria. Derive energy from aerobic respiration, capable of sustained and vigorous activity.
Term
White fibers (Skeletal muscle)
Definition
Fast-twitch fibers. Anaerobic and contain less myoglobin and fewer mitochondria. Have a greater rate of contraction than red fibers. They fatigue more easily.
Term
Thin filament of sarcomere
Definition
chains of globular actin molecules associated with troponin and tropomyosin.
Term
Thick filaments of sarcomere
Definition
composed of organized bundles of myosin molecules; each with a head and tail region.
Term
Organization of sarcomere: Z lines
Definition
define boundaries between sarcomeres, and anchor the thin filaments.
Term
Organization of sarcomeres: M line
Definition
Line that runs down the center of the sarcomere.
Term
Organization of sarcomeres: I band
Definition
Region of filament containing thin filaments only.
Term
Organization of sarcomeres: H zone
Definition
Region of sarcomere containing thick filaments only
Term
Organization of sarcomeres: A band
Definition
Region of sarcomere: spans the entire lengtho f the thick filaments and any overlapping portion of the thin filaments.
Term
Contraction of muscle: Sarcomere zone changes
Definition
During contraction, A band is not reduced in size; H zone and I band are.
Term
Neuromuscular junction
Definition
Link between the nerve terminal (synaptic bouton) and the sarcolemma of the muscle fiber.
Term
Shortening of the sarcomere
Definition
Once an AP is generated, conducted along the sarcolemma and the T system, into the interior of the fiber. The sarcoplasmic reticulum releases calcium ions into the sarcoplasm, causing myosin-binding sites to be exposed. Myosin molecules bind to the binding sites, forming actin-myosin cross bridges, causing myosin to pull on the actin molecules, and draw the thin filaments toward the center of the H zone, and shorten the sarcomere.
Term
Role of calcium in skeletal muscle contraction
Definition
Once inside the sarcoplasm, calcium binds to the troponin molecules, causing tropomyosin strands to shift, and exposing the myosin-binding sites on the actin filaments.
Term
Rigor mortis
Definition
After death, ATP is no longer producedd and the myosin heads can't detach from actin, and the muscle cannot relax.
Term
Relaxation phase of sarcomere contraction
Definition
calcium is pumped back into the sarcoplasmic reticulum. Myosin dissociates from the thin filament, sarcomere returns to original width.
Term
Stimulus intensity of muscle fibers
Definition
Individual fibers exhibit all-or-none rsponse. Whole muscle does not exhibit this. Strength of the contraction can increase as stimulus strength is increased by involving more fibers.
Term
Tonus
Definition
continual low-grade contractions of muscle; essential for both voluntary and involuntary muscle contraction.
Term
Simple Twitch
Definition
Response of a signle muscle fiber to a brief stimulus at or above the threshold stimulus. Consists of a latent period, contraction period, and relaxation period.
Term
Frequency summation: Tetanus.
Definition
When muscle contractions begin to combine, becoming stronger and more prolonged. Become continuous sometimes.
Term
Skeletal muscle in a nutshell
Definition
Striated
Voluntary
Somatic innervation
Many nuclei per cell
Calcium required for contraction
Term
Cardiac Muscle in a nutshell
Definition
Striated
Involuntary
Autonomic innervation
1-2 nuclei per cell
Calcium required for contraction.
Term
Smooth muscle -- other stuff
Definition
Responsible for involuntary actions; innervated by ANS. Found in digestive tract, bladder, uterus, blood vessel walls. Contain one centrally located nucleus. Filaments (actin & myosin) lack organization of skeletal sarcomeres, and hence the striations.
Term
Smooth muscle contractions
Definition
Result from the sliding of actin and myosin over one another via calcium regulation. Slower, capable of being sustained longer than skeletal muscle contractions. Have both inhibitory and excitatory synapses. Demonstrates myogenic activity.
Term
Myogenic activity
Definition
Property of reflexively contracting without nervous stimulation (smooth and cardiac muscle).
Term
Smooth Muscle in a nutshell
Definition
Non-striated
Involuntary
Autonomic innervation
1 nucleus per cell
Calcium required for contraction.
Term
Cardiac Muscle: Other stuff
Definition
Present in muscle tissue of the heart. Possess characteristics of skeletal and smooth muscle fibers. FIlaments arranged in sarcomeres, and has a striated appearance. Only one or 2 nuclei. Innervated by ANS, serves only to modulate its beat. Myogenic.
Term
Creatine Phosphate
Definition
High-energy storage compound. Produced during resting periods via a reaction that transfers ATP phosphate group to creatine.
Term
Myoglobin
Definition
Hemoglobin-like protein, found in muscle tissue. Has a high oxygen affinity. Binds to oxygen from bloodstream, holds onto it until available oxygenis depleted. Acts as additional oxygen reserve.
Term
Connective tissue
Definition
Major function is to bind and support other tissue. COmposed of sparsely scattered population of cells in an amorphous ground substance.
Term
Loose connective tissue
Definition
Found throughout the body; binds epithelium to underlying tissues. Is the packing material that holds organs in place. Has three kinds of proteinaceous fibers.
Term
Proteinaceous fibers in loose connective tissue
Definition
Collagenous fibers: collagen; have good tensile strength
Elastic fibers: elastin, endow resilience
Regular Fibers: branched, tightly woven fibers that join connective and adjoining tissue.
Term
Fibroblasts
Definition
Cell type in loose CT: secrete substances that are components of extracellular fibers
Term
Macrophages
Definition
Major cell type in loose CT: engulf bacteria and dead cells via phagocytosis.
Term
Dense connective tissue
Definition
Has high proportion of collagenous fibers. Organized into parallel bundles that give fibers great strength.
Term
Tendons
Definition
Composed of dense connective tissue; attaches muscle to bone.
Term
Origin
Definition
End of the muscle attached to the stationary bone. (Proximal end)
Term
Insertion
Definition
End of the muscle attached to the bone that moves during contraction (distal end).
Term
Insertion
Definition
End of the muscle attached to the bone that moves during contraction (distal end).
Term
Synergistic muscles
Definition
Assist the principle muscles during movement
Term
Flexor muscle
Definition
Contracts to decrease the angle of a joint
Term
Extensor Muscle
Definition
Will contract to straighten the joint
Term
Abductor
Definition
Moves a part of the body away from the body's midline.
Term
Adductor
Definition
Moves a part of the body toward the midline.
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