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Muscular Disease
Disases of the muscles
13
Medical
Graduate
11/09/2010

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Cards

Term
brody's
Definition
Term
fast twich
Definition
IIA and IIB - white color; little mitochondria (glycolytic); high sarcoplasmic reticular Ca2+ capacity; high fatigability
Term
slow twitch
Definition
type I - phospholamban (inhibits SRCa fibers) is inhibited by epinephrine; Red from mitochondrial capacity (oxidative); low fatigability
Term
smooth muscles
Definition
calmodulin is Ca2+ sensor (multiple isoforms)
Term
phospholamban
Definition
inhibits SRCa fibers; is inhibited by epinephrine; slow, cardiac and smooth muscles - sympathetic nervous system activation
Term
tetany
Definition
frequency is high enough to maintain calcium at a constant high level; allows constaint force for smooth movements
Term
muscle lenthening
Definition
no change to force, incresed velocity and shortening capacity
Term
muscle hypertrophy
Definition
force increases but velocity and shortening capacity does not change
Term
MuRF2
Definition
ubiquitin ligase; inhibtis transcription by exporting transcription factors; leads to decrease protein synth and increased degradation; causes atrophy of muscles
Term
PI3K
Definition
atrophy is signaled
Term
deinervation
Definition
Ach receptors spread out and cause eratic stimulation; with in 8-12 months atrophy occurs due to lack of stimulation
Term
isotonic contraction
Definition
force is held constant - measure change in lenght of muscle
Term
ismetric contraction
Definition
the length of the muscle is constant and the force generated is measured
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