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Muscles and Muscle tissue
structure and function
69
Anatomy
Undergraduate 2
03/16/2011

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Term
What are the characteristics of muscle tissue?
Definition
excitability
contractibility
extensibility
elasticity
Term
What are the functions of muscle tissue?
Definition
producing movement,
maintaining posture/body heat,
stabilizing joints,
generating heat,
protect fragile organs.
Term
What are the connective tissue sheaths, superficially to deep?
Definition
Epimysium, perimysium, endomysium.
Term
What is a bundle of muscle fibers?
Definition
a fascicle.
Term
What is an aponeuroses?
Definition
A sheet like tendon.
Term
What is the red pigment that stores O2 in muscles?
Definition
Myoglobin
Term
What is the contractile unit of a muscle cell?
Definition
sarcomere.
Term
What is an A band?
Definition
A bands are the dark bands of a sarcomere that contain the H zone.
Term
Tropomyosin
Definition
protein on actin that blocks myosin binding sites
Term
Troponin
Definition
inhibitory protein that binds Ca2+ on actin.
Term
Titin
Definition
protein that extends from Zdisc forming attachment to myosin.
Term
dystrophin
Definition
links actin to integral proteins of the sarcolemma.
Term
What makes up the triad?
Definition
Ttubules + terminal cisternae(2)
Term
What are the voltage-gated channels that release Calcium ions from SR?
Definition
dHP and Ryanodine.
Term
Somatic motor neurons
Definition
neurons that activate muscle fibers
Term
junctional folds
Definition
where ach receptors are located
Term
what is the enzyme that breaks down ach to acetic acid and choline for reabsorption?
Definition
acetylcholinesterase.
Term
Generation of AP along sarcolemma events:
Definition
1)Local depolarization: chemically ligand gated channels are opened by ach attachment that allows sodium in and potassium out.
2)Generation and Propogation of AP: spreads in all directions, and once threshold is reached(endplatepotential) AP is spread down sarcolemma.
Term
What is the polarized mV? Depolarized?
Definition
-70mV; +30mV
Term
refractory period
Definition
cell cannot be stimulated again unless repolarization is complete.
Term
What restores the ionic conditions of cell? The electrical conditions?
Definition
Na+, K- pump; repolarization
Term
What is the point of no return?
Definition
-55mV
Term
Motor end plate
Definition
End of sarcolemma where Ach binds.
Term
Excitation
Definition
action potential leading to calcium release out of sarcoplasmic reticulum.
Term
Contraction
Definition
Calcium removes tropomyosin blockade so myosin can bind and muscle can contract.
Term
powerstroke
Definition
myosin pulls toward M line.
Term
What are the main factors of contraction?
Definition
Ca2+ and ATP
Term
Latent Period
Definition
first few miliseconds where excitation occurs.
Term
voltage gated calcium channels
Definition
@synaptic cleft where calcium entry triggers release of Ach
Term
chemically gated Na/K channels
Definition
local voltage change @ end plate potential.
depolarization.
Term
voltage gated sodium channels
Definition
further depolarizes and results in AP propogation.
Term
volatge sensitive proteins
Definition
dHP and ryanodine.
stimulate SR release of Ca.
Term
What occurs when Ca is released from SR?
Definition
Ca binds to troponin, which activated tropomyosin. Then myosin attaches and crossbridge is formed.
Term
What happens at the end of contraction?
Definition
pumps of SR reclaim Ca from cytosol and troponin and tropomyosin return and muscle fiber relaxes.
Term
Isotonic contraction
Definition
muscle shortens and does work
Term
isometric
Definition
muscle does not shorten
Term
concentric
Definition
muscle shortens and does work
Term
eccentric
Definition
muscle lengthens (50%more forceful)
Term
motor unit
Definition
motor neuron and all fibers it stimulates.
Term
What is an example of fine control?
Definition
moving a finger or eye.
-more precise.
smaller motor unit.
Term
myogram
Definition
graphic recording of contractile activity
Term
muscle twitch
Definition
response of a motor unit to a single action potential of is motor neuron.
Term
3 phases of a myogram
Definition
1)Latent Period- EC coupling occurs
2)Contraction period- crossbridge active
3)Relaxation period- reentry of Ca in SR
Term
What are graded responses?
Definition
1)change of frequency of stimulation
2)chnage of strength of stimulation
Term
wave summation
Definition
2nd twitch is stronger because it hits before 1st twitch finished. Contracting doubly making bigger impact.
Term
incomplete tetanus
Definition
led by wave summation.
most common.
more tension results.
Term
fused tetanus
Definition
superhuman.
Term
subthreshold stimulus
Definition
stimuli that produce no movements
Term
threshold stimulus
Definition
stimulus where 1st observable contraction occurs
Term
maximal stimulus
Definition
strongest stimulus that produces increased contraction and all muscle motor units are recruited.
Term
direct phosphorylation of ADP by creatine phosphate.
Definition
creatine phosphate+ADp=creatine+ATP
result: 1 ATP per CP
-only 15 secs worth.
Term
glycolysis
Definition
anaerobic respiration
Glucose is broken down into 2 pyruvic acids, then to lactic acids.
result: 2 ATP per glucose
-30-60s worth
Term
aerobic respiration
Definition
glucose+oxygen=CO2+H2O+ATP.
result=32-36 ATP
-last hours.
Term
Treppe
Definition
increasing availability of calcium ions in the sarcoplasm
STAIRCASE EFFECT
Term
Muscle tone is accounted by:
Definition
spinal reflexes to maintain posture/joints and keeping muscles firm and healthy.
Term
contracture
Definition
cramping because lack of ATP does not allow crossbridge to detach.
Term
How much of energy released from muscle contraction is converted to useful work?
Definition
40%
Term
hypertrophy
Definition
grow in size
Term
Slow Twitch I
Definition
slow oxidative fibers
32-36 ATP formed.
aerobic.
red in color.
endurance activities.
Term
IIa
Definition
"hybrid"
aerbic+glycolysis
red-pink color
Term
Fast Twitch IIb
Definition
Anaerobic Glycolysis
2 ATP formed
white color.
Term
bulbs that release ach in smooth muscles
Definition
varicosities
Term
junction at which ach is expelled
Definition
diffuse junction
Term
infoldings of sarcolemma of smooth muscle
Definition
caveloae
Term
Ca binding site in smooth muscle
Definition
calmodulin
Term
Z discs of smooth muscle
Definition
Dense bodies
Term
allows a hollow organ to fill or expand slowly to accomodate greater volume.
Definition
stress-relaxation response
Term
embryonic mesoderm cells
Definition
myoblasts.
Term
hyperplasia
Definition
accelerated growth by splitting and multiplying.
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