Term
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Definition
1. upper motor neuron syndrome
2. hypertonicity (velocity and direction dependent)
3. hyperreflexia
4. extensor plantar response (babinski)
5. loss of dexterity and weakness
6. painful flexor or extensor spasms |
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Term
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Definition
| agonist at presynaptic GABA-b receptors on spinal interneurons; prevents the release of glutamate and aspartate from spinal interneurons |
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Term
| adverse effects of Baclofen |
|
Definition
| drowsiness > dizziness > weakness |
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Term
|
Definition
| agonist at presynaptic alpha-2 receptors in CNS, preventing release of NE; synergistic with baclofen |
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Term
| adverse effects of tizanidine |
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Definition
|
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Term
| contraindications for tizanidine |
|
Definition
liver and kidney disease (metabolism and excretion)
metabolized with P450 system of liver |
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Term
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Definition
tricyclic that blocks reuptake of serotonin and NE at nerve endings
causes sedation and dry mouth |
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Term
|
Definition
facilitates postsynaptic GABA-a action, thereby increasing chloride conductance and hyperpolarization
-sedation |
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Term
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Definition
calcium modulator
can cause dizziness, ataxia, and excessive sedation |
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Term
|
Definition
works at the sarcoplasmic reticulum by preventing the release of calcium and therefore preventing actin-myosin contraction
*can be used to treat malignant hypertension |
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Term
| adverse effects of dantrolene |
|
Definition
weakness > dizziness > hepatotoxicity
-rarely given orally because can cause liver failure
-IV can cause phlebitis |
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Term
|
Definition
1. multiple sclerosis
2. cervical spondylosis
3. trigeminal neuralgia |
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Term
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Definition
| second line therapy for MS because of higher cost and contraindications -renal failure |
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Term
|
Definition
1. first line therapy for malignant hypertension and neuroleptic malignant syndrome
2. third line muscle relaxant for MS (hepatic risk) |
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