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Muscarinic Antagonists
Drugs and mecahnisms
10
Pharmacology
Professional
11/16/2010

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Term
MUSCARINIC receptor antagonists
Definition
Block ACh action at muscarinic receptors
Term
BELLADONNA ALKYLOIDS
Definition
Atropine(minimal CNS effects)and Scopolamine (marked drowsiness and amnesia)
Term
Treatment of Parkinson's
Definition
Used to offset excessive levels of ACh in conjunction with a dopamine precursor
Term
Some muscarinic antagonists
Definition
Propantheline, Dicyclomine, Oxybutinyn
Term
IPRATROPIUM BROMIDE
Definition
A synthetic analog of atropine, used as an inhalation to target bronchial muscle spasms
Term
TIOTROPIUM
Definition
Also an antimuscarinic agent
Has a longer action and can be given once daily
Term
Carbachol and Bethanechol overdose
Definition
Cholinergic poisoning can be treated with muscarinic antagonists.
Must use a drug with tertiary amine group to counteract organophosphate CNS effects.
Term
Myasthenia Gravis and muscarinic antagonists
Definition
Offsets side effects of myasthenia gravis treatment
Term
ANTIMUSCARINIC OVERDOSE
Definition
1. Remove unabsorbed drug
2. Supportive therapy
3. Cholinesterase inihbitor that can cross BBB
Term
Antimuscarinic drug contraindications
Definition
Glaucoma, Cardiac disease, prostatic hypertrophy with urinary retention, people sensitive to hyperthermia
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