Term
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Definition
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Term
key to vasculitis diagnosis |
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Definition
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Term
systemic vasculitis symptoms |
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Definition
fever, malaise, weight loss |
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Term
vasculitis large vessel symptoms |
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Definition
pulseless, blindness, CVA, syncope |
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Term
vasculitis medium vessel symptoms |
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Definition
CAD, renal artery, CVA, mononeuritis (wrist/foot drop) |
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Term
vasculitis small vessel symptoms |
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Definition
palpable purpura, Raynauds/gangrene |
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Term
vasculitis large vessel classification |
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Definition
takayasu temporal arteritis |
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Term
vasculitis medium vessel classification |
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Definition
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Term
vasculitis small vessel classification |
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Definition
churg-strauss syndrome wegeners granulamatosis henoch-schonlein purpura hypersensitivity/cutaneous vasculitis CVD associated vasculitis Goodpastures syndrome Behcet disease |
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Term
vasculitic involvement of small cutaneous vessels |
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Definition
leukocytoclastic vasculitis |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
aka leucocystoclastic vasculitis/allergic vasculitis |
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Definition
hypersensitivity vasculitis |
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Term
hypersensitivity vasculitis causes |
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Definition
viral/bacterial/atypical infections medicine reactions CVD or vasculitis idiopathic |
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Term
hypersensitivity vasculitis treatment |
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Definition
find cause and stop/treat this |
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Term
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Definition
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Term
necrotizing (caseating) granulomatous vasculitid disease |
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Definition
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Term
typical onset at age 20-40 |
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Definition
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Term
treatment of wegeners granulomatosis |
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Definition
glucocorticoids and cyclophosphamide improves survival |
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Term
wegeners granulmoatosis main sites of involvement |
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Definition
ELK. ENT (UR, optic, Otic, sinusitis) LRT Kidney (GN) |
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Term
main lab study for wegeners granulomatosis |
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Definition
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Term
classification criteria for wegeners granulomatosis (must have 2/4) |
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Definition
1. nasal or oral inflammation 2. abnormal chest radiograph 3. urinary sediment (rbc) 4. granulomatous inflammation on biopsy |
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Term
causes deformity of the nose secondary to granulomatous disease |
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Definition
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Term
classification criteria for Churg-Strauss syndrome (must have 4/6) |
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Definition
1. asthma 2. eosinophila >10% wbc 3. mononeuropathy or polyneuropathy 4. transitory pulmonary infiltrates 5. paranasal sinus abnormality 6. biopsy with extravascular eosinophils |
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Term
Vasculitis lab markers of inflammation |
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Definition
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Term
vasculitis lab hematologic changes |
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Definition
leukocytosis usually with neutrophilia anemia thrombocytosis |
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Term
vasculitis lab complement levels |
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Definition
depressed. consumption of complement proteins due to antibody binding |
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Term
vasculitis lab high RF with low complements |
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Definition
hepatitis related PAN in RA: most likely rheumatoid vasculitis cryoglobulinemic vasculitis |
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Term
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Definition
anti-neutrophil cytoplasmic antibody |
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Term
staining patterns of ANCA |
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Definition
cytoplasmic (c-ANCA) perinuclear (p-ANCA) |
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Term
vasculitis tissue biopsy from |
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Definition
temporal artery, muscle, sural nerve, skin, nasal/sinus, lung, kidney |
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Term
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Definition
claudication/ischemic symptoms |
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Term
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Definition
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Term
classification criteria: polyarteritis nodosa (3/10 required) |
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Definition
1. weight loss >4g 2. livedo reticularis 3. testicular pain or tenderness 4. myalgias, weakness, leg tenderness 5. mononeuropathy or polyneuropathy 6. diastolic bp >90 mmHG 7. elevated BUN or creatinine 8. hepatitis B virus 9. arteriographic abnormality 10. biopsy of small or medium artery containing PAN |
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Term
polymyalgia rheumatica characteristics |
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Definition
older patient (over 50), caucasian, normal physical examination, aching/stiffness muscle pain (shoulders/pelvic girdle) at least 1 month severe morning stiffness and gelling |
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Term
polymyalgia rheumatica DD possibilities |
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Definition
temporal arteritis, viral myalgia, RA, polymyositis, multiple myeloma, OA, fibrositis, depression, occult infection, occult malignancy, endocrinopathy |
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Term
Giant cell (temporal ) arteritis classification (3/5) |
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Definition
1. over 50 at disease onset 2. new headache 3. temporal artery abnormality 4. elevated westergren ESR >50 5. abnormal artery biopsy with mononuclear cell infiltrate, granulmoatous inflammation, usually with multinucleated giant cells |
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Term
secondary forms of vasculitis |
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Definition
RA, SLE, lymphoma, other tumors, infectoin, drugs |
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