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MSK
5. vasculitis
39
Classics
4th Grade
08/01/2012

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Cards

Term
involves multiple organs
Definition
vasculitis
Term
key to vasculitis diagnosis
Definition
clinical suspicion
Term
systemic vasculitis symptoms
Definition
fever, malaise, weight loss
Term
vasculitis large vessel symptoms
Definition
pulseless, blindness, CVA, syncope
Term
vasculitis medium vessel symptoms
Definition
CAD, renal artery, CVA, mononeuritis (wrist/foot drop)
Term
vasculitis small vessel symptoms
Definition
palpable purpura, Raynauds/gangrene
Term
vasculitis large vessel classification
Definition
takayasu
temporal arteritis
Term
vasculitis medium vessel classification
Definition
polyarteritis nodosa
Term
vasculitis small vessel classification
Definition
churg-strauss syndrome
wegeners granulamatosis
henoch-schonlein purpura
hypersensitivity/cutaneous vasculitis
CVD associated vasculitis
Goodpastures syndrome
Behcet disease
Term
vasculitic involvement of small cutaneous vessels
Definition
leukocytoclastic vasculitis
Term
mottled erythema
Definition
livedo reticularis
Term
purpuric lesions
Definition
small vessel vasculitis
Term
palpable purpura
Definition
small vessel vasculitis
Term
aka leucocystoclastic vasculitis/allergic vasculitis
Definition
hypersensitivity vasculitis
Term
hypersensitivity vasculitis causes
Definition
viral/bacterial/atypical infections
medicine reactions
CVD or vasculitis
idiopathic
Term
hypersensitivity vasculitis treatment
Definition
find cause and stop/treat this
Term
male:female ratio 1.3:1
Definition
wegeners granulomatosis
Term
necrotizing (caseating) granulomatous vasculitid disease
Definition
wegeners granulomatosis
Term
typical onset at age 20-40
Definition
wegeners granulomatosis
Term
treatment of wegeners granulomatosis
Definition
glucocorticoids and cyclophosphamide improves survival
Term
wegeners granulmoatosis main sites of involvement
Definition
ELK.
ENT (UR, optic, Otic, sinusitis)
LRT
Kidney (GN)
Term
main lab study for wegeners granulomatosis
Definition
c-ANCA
Term
classification criteria for wegeners granulomatosis (must have 2/4)
Definition
1. nasal or oral inflammation
2. abnormal chest radiograph
3. urinary sediment (rbc)
4. granulomatous inflammation on biopsy
Term
causes deformity of the nose secondary to granulomatous disease
Definition
wegeners granulomatosis
Term
classification criteria for Churg-Strauss syndrome (must have 4/6)
Definition
1. asthma
2. eosinophila >10% wbc
3. mononeuropathy or polyneuropathy
4. transitory pulmonary infiltrates
5. paranasal sinus abnormality
6. biopsy with extravascular eosinophils
Term
Vasculitis lab markers of inflammation
Definition
elevated ESR
elevated CRP
Term
vasculitis lab hematologic changes
Definition
leukocytosis usually with neutrophilia
anemia
thrombocytosis
Term
vasculitis lab complement levels
Definition
depressed. consumption of complement proteins due to antibody binding
Term
vasculitis lab high RF with low complements
Definition
hepatitis related PAN
in RA: most likely rheumatoid vasculitis
cryoglobulinemic vasculitis
Term
ANCA stands for
Definition
anti-neutrophil cytoplasmic antibody
Term
staining patterns of ANCA
Definition
cytoplasmic (c-ANCA)
perinuclear (p-ANCA)
Term
vasculitis tissue biopsy from
Definition
temporal artery, muscle, sural nerve, skin, nasal/sinus, lung, kidney
Term
do an arteriogram if
Definition
claudication/ischemic symptoms
Term
do EMG/NCS if
Definition
muscle disease suspected
Term
classification criteria: polyarteritis nodosa (3/10 required)
Definition
1. weight loss >4g
2. livedo reticularis
3. testicular pain or tenderness
4. myalgias, weakness, leg tenderness
5. mononeuropathy or polyneuropathy
6. diastolic bp >90 mmHG
7. elevated BUN or creatinine
8. hepatitis B virus
9. arteriographic abnormality
10. biopsy of small or medium artery containing PAN
Term
polymyalgia rheumatica characteristics
Definition
older patient (over 50), caucasian, normal physical examination, aching/stiffness
muscle pain (shoulders/pelvic girdle) at least 1 month
severe morning stiffness and gelling
Term
polymyalgia rheumatica DD possibilities
Definition
temporal arteritis, viral myalgia, RA, polymyositis, multiple myeloma, OA, fibrositis, depression, occult infection, occult malignancy, endocrinopathy
Term
Giant cell (temporal ) arteritis classification (3/5)
Definition
1. over 50 at disease onset
2. new headache
3. temporal artery abnormality
4. elevated westergren ESR >50
5. abnormal artery biopsy with mononuclear cell infiltrate, granulmoatous inflammation, usually with multinucleated giant cells
Term
secondary forms of vasculitis
Definition
RA, SLE, lymphoma, other tumors, infectoin, drugs
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