Term
| What is parallel fibered bone? |
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Definition
| It is lamellar bone and primary osteonal bone. |
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Term
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Definition
they are trapped osteoblasts that regulate Ca uptake/deposition. they communicate via cannaliculi
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Term
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Definition
| Collagen, bone matrix proteins and alkaline phosphate. |
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Term
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Definition
2 alpha I +
1 alpha II chains |
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Term
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Definition
Ca binding protein
recruits osteoclasts |
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Term
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Definition
it makes up 10% of bone protein.
links to hydoxyapetite
regulates crystal growth |
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Term
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Definition
Secreted by osteoblasts, clasts and macros
enhances cell survival,
Inhibit mineralization. |
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Term
| What are the clinical features of Rickets? |
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Definition
Siezrues, apnea, and tetany.
In children:
bowing of long bones
Harrisons groove - line around diaphragm
Radiology:
Widening of epiphysial plate, cupping,
shaft deformities. |
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Term
| What is the pathology of rickets? |
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Definition
Collagen normal,
bone mineral deficient |
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Term
| Where is the growth plate? |
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Definition
| Bw the Epiphysis and Metaphysis. |
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Term
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Definition
| It is dense bone with haversian systems |
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Term
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Definition
It is cancellous bone with
buttresses arrayed along stress lines |
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Term
What is Fi
Fibrodysplasia Ossificans Progressiva (FOP)? |
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Definition
It is a rare dz
mm turns to bone
Mut in gene -> too much BMP |
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Term
What happens when osteoclasts are mechanically stimulated?
How does this effect Osteoblasts? |
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Definition
Osteoclasts release prostoglandins when mechanically stimulated.
Prostaglandins inhibit apoptosis of osteoblasts.
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Term
| What is osteopenia, what are its causes? |
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Definition
It means thins bones, caused by:
Osteoporosis
VitD def
hyerthyroidism
hyperparathyroidism |
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Term
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Definition
Low bone mass
microarchitecture disruption
normal mineralization |
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Term
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Definition
Poorly mineralized bone.
Rickets is a form of juvenile osteomalacia |
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Term
| What is osteogenesis imperfecta? |
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Definition
Collagen type I defect
significant reduction in cortical width
red in cancellous bone volume
red in trabecular # and width
inc bone turnover |
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Term
| What is the effect of Thalasemia on bones? |
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Definition
There is a lower amount of RBCs in thalasemi... this causes hypoxia.
Bone marrow expands to accomodate RBC productions and causes osteoporosis, even in childern.
Skull gets spiky hair effect on xray.
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Term
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Definition
It has irregular collagen network. It is the immature form and found in first stage of injury repair.
It is relatively less mineralized. |
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Term
| What kind of bone makes up lamellar and primayr osteonal bone? |
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Definition
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Term
| what cells make type I collagen? |
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Definition
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Term
| Seed crystals initiate formation of larger needle-shaped crystals oriented parallel to collagen. What protin regulates this process? |
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Definition
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Term
T/F:
Periosteum regulates healing in Fx |
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Definition
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Term
T/F:
No transphysial vascularization is present in the growth plate. |
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Definition
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Term
T/F:
Bone responds to tension with either osteolytic or osteoproliferative response. |
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Definition
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Term
| At any given time 3% of cortical bone and 7% of trabecular bone is remodling. Based on this knowledge, which type of bone would have a higher life expectancy? |
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Definition
Cortical bone has a 20 year life expectancy.
vs 4 yrs for trabecular bone. |
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Term
What type of cell produces collagenase?
What does collagenase do? |
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Definition
Activated osteoblasts.
It digests osteoid bone surface, exposing mineralized bone. -> exposed bone matrix is chemotactic for osteoclasts. |
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Term
| What are the side effects of Bishphosphonates and other osteoclast inhibitors such as fosamax and alendronate and zolecronica acid? |
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Definition
Hypocalcemia -> compensatory increase in parathyroid hormone.
Osteonecrosis of the jaw. |
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Term
| what is the pathology of osteogenesis imperfecta? |
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Definition
genetic type I collagen defect.
normal mineralization but significant reduction in cortical width. |
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Term
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Definition
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Term
| What do you call a distal radius fx at the wrist? |
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Definition
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Term
Name the force that generated the following Fx:
Green stick
Hair line |
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Definition
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Term
Name the force the generated the following fx:
Comminuted
Butterfly
Buckle |
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Definition
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Term
| What does a petechial rash at the site of fx indicate? |
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Definition
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