Term
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Definition
seen in scleroderma, they are patches of thickened skin. blood vessels are obliterated
can be a small patch
can be long and linear affecting one or more extremities
can be Coup de Sabre - affect face and forehead |
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Term
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Definition
a system type of scleroderma. inc. collagen deposits in tissues and organs with skin fibrosis
-lethal
-always has internal organ disease
-affects mainly women in 30s-50s; all races
-raynaud's phenomenon
-poor circulation
-calcification
-decreased hematocrit |
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Term
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Definition
-speckled or nucleolar FANA pattern
-Abs for Scl-70 and Topoisomerase-1
-CD4 cellular activity
-Ig and complement in renal arterioles causing narrowing (resembles malignant nephropathy)
-polyclonal hypergammagolbulinemia |
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Term
| anticentromere FANA pattern |
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Definition
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Term
| 3 stages of skin abnormalities in PSS |
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Definition
| edematous, sclerotic, atrophic |
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Term
| features of CREST syndrome |
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Definition
Calcinosus
Raynauds
Esophageal dysmotility
Sclerodactyly
Telangiectasis |
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Term
| differentiation of MCTD from similiar appearing diseases |
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Definition
there will not be renal or CNS involvement or wide spread skin changes like in PSS
the arthritis is non-deforming like in RA
FANA positive like in SLE from which extractable nuclear Abs can be retrieved, however, with adding RNAase, it is positive for ribonuclear protein and negative for the Smith Ag in MCTD, and the opposite in SLE |
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Term
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Definition
inflammation involving the distal forearm and leg
fascia is infiltrated |
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Term
| eosinophilic fascitis labs |
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Definition
-very high eos
-high hypergammaglobulinemia, IgG, ESR
-low RF, FANA, Anti-DNA Ab |
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Term
| differences between EF and PSS |
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Definition
slighly more male in EF, slightly more female in PS
no foot involvment in EF
low FANA in EF
low raynauds, low GI involvment |
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Term
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Definition
SPIROCHETE, borrelia bergdoferi
bacteria is in tick and it is most dangerous to humans during the second year of the tick's (Ixodes dammini) life; the nymph stage. this is when it is big enough to feel on deer and humans |
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Term
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Definition
stage 1: erythema migrans rash, mild flu or meningitis like symptoms
stage 2: cardiac, neurologic, joint
stage 3: chronic skin lesions, CNS involvement, chronic monoarthritic knee |
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Term
| IgG and IgM trend in Lyme disease |
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Definition
IgM spikes to detectable level within two weeks, peaks in months, and then drops off.
IgG Ab titer rises more slowly, but doesn't peak until 1-2 years |
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Term
| what potential treatment antibiot for lyme disease shouldn't you give to patients with penicillin sensitivity and why shouldn't you give it? |
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Definition
| doxyclycline and bc it turns their teeth brown |
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Term
| what is the std antibiot regemin for pts with lyme disease? |
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Definition
| amox 3x daily for 21 DAYS |
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Term
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Definition
*Plain films
MRI
Arthroscopy
No blood test or laboratory analysis to confirm the diagnosis |
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Term
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Definition
CBC
Acute phase reactants
*Rheumatoid factor
Biopsy of rheumatoid nodules
X-ray |
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Term
| best tests for Sjogrens dx? |
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Definition
*Salivary gland biopsy
Parotid sialography
ANA speckled pattern
Antibody to Ro/ss-A or La/ss-B antigens |
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Term
best tests for Psoriatic arth dx?
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Definition
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Term
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Definition
Hematologic disorder-complement
ANA (Anti dsNA or SM)
Antiphospholipid antibodies
*Biopsy
X-ray |
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Term
best tests for Reactive Arthritis dx |
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Definition
X-ray
CBC
Acute phase reactants
*HLA-B27
Synovial fluid |
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Term
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Definition
*Synovial fluid
X-ray
Tophus
Uric acid |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| heart block in lyme disease |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| sjogren's dry mucus membrane / causes sexual problems |
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Term
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Definition
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