Term
|
Definition
GABA-A agonist --> inhibits NT release --> sedation
Side effect sedation |
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Term
|
Definition
GABA-B agonist --> presynaptic --. closes Ca channels --> inhibits NT release
Less sedating than diazepam
Inhibits substance P --> analgesic |
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Term
|
Definition
GABA analogue, but blocks Ca channel --> inhibitory
Spasmolytic |
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Term
|
Definition
(similar to gabapentin)
Ca channel blocker
Used for fibromyalgia
adverse effect = memory deficits (take before bed) |
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Term
|
Definition
Increases pre/postsynaptic inhibition (spasmolytic)
Analgesic
Adverse effects = drowsiness, hypertension, dry mouth |
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Term
|
Definition
Glutamate blocker --> inhibits NT release
spasmolytic for ALS tx |
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Term
|
Definition
Binds to ryanodine receptors --> blocks Ca release from SR
No effect on cardiac / smooth muscle
Used to tx malignant hyperthermia (constitutive Ca release) |
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Term
|
Definition
| blocks vesicular release of ACh --> spasmolytic |
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Term
|
Definition
| Blockade of 5HT2 on dorsal horns --> spasmolytic |
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Term
|
Definition
inhibits production of crystal-induced chemotactic factor (CCF) which is released by urate crystals and causes inflammation
- does not have analgesic / anti-pyretic activity |
|
|
Term
| Probenecid / sulfinpyrazone |
|
Definition
Uricosuric, used for chronic/tophaceous gout (only if uric acid under-excreter)
- Competes w/ uric acid binding to organic acid transporter in proximal tubule --> inhibits reabsorption of uric acid --> increases excretion |
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Term
|
Definition
Used for chronic gout in uric acid over-producers
Competes w/ xanthine for xanthine oxidase
-hypoxanthine & xanthine are soluble & excreted renally (as well as allouprinol metabolite, alloxanthine) |
|
|
Term
| MRI weightings - T1 for? T2 for? PD for? |
|
Definition
T1 = anatomy
T2 = pathology
PD = cartilage |
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|
Term
| Pharm rx for fibromyalgia |
|
Definition
|
|
Term
| central cord SCI symptoms |
|
Definition
UE deficit > LE
UE = LMN
LE = UMN
distal extremities worse than proximal |
|
|
Term
| Brown sequard SCI symptoms |
|
Definition
contralteral pain/temp 2 segments below
ipsilateral motor / proprioception loss |
|
|
Term
| Anterior cord SCI symptoms |
|
Definition
loss of motor / pain / temp
preserved touch & proprioception (DCML)
poor prognosis |
|
|
Term
| Posterior cord SCI symptoms |
|
Definition
loss of proprioception & light touch
preservation of motor / pain / temp
(foot-slapping gait) |
|
|
Term
| Cervical myelopathy symptoms |
|
Definition
tandem gait difficulty
hyper / hypo reflexes
hoffman's sign
babinski
clonus |
|
|
Term
| Cervical radiculopathy symptoms |
|
Definition
Spurling's test +
LMN signs at level of compression |
|
|
Term
| 3 fractures unique to kids |
|
Definition
|
|
Term
|
Definition
metatarsus adductus
internal tibial torsion
femoral anteversion |
|
|
Term
|
Definition
a. Increased distal median sensory latency time
b. Increased distal median motor conduction time
c. Early denervation of thenar muscles |
|
|
Term
|
Definition
1. Complex = bones fused
a. Skin graft can be taken from volar wrist (same color)
2. Simple = no structures fused except skin – can be easily separated |
|
|
Term
| four signs of tendon sheath infections (kanavel) |
|
Definition
1. Diffuse finger swelling
2. Tenderness
3. Finger held in flexed position
4. Excruciating pain w/ extension |
|
|
Term
| bacterial cause of necrotizing fasciitis |
|
Definition
|
|
Term
| time window for reconstructive surgery |
|
Definition
| need to operate in first 6 hours |
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