when a MAN'S on Meth he has DAFT SNARLS

M: additive Myelosuppresion or hepatic toxicity w/other marrow suppressive or hepatotoxic drugs

A: Anemia

N: Nausea and vomiting

S: Sulfonamides and trimethoprim increses toxicity of high dose

D: Dihydrofolate reductase (takes dihydrofolic acid to tetrahydrofolate for synthesis of purines (T))

A: Antineoplastic agent

F: Folinic acid (leucovorin) minimizes hematologic toxicity of high dose or OD

T: Thrombocytopenia

S: Stomatitis (inflammation of mucous membranes)

N: Nephrotoxicity

A: Arthritis of the

R: Rheumatoid kind

L: Leukocytopenia

S: cell cycle S specific

1st PSP SCREAMS

1st: 1st generation cephalosporin

P: Pseudomembrane colitis

S:Superinfection

P: Probenecid inhibits excretion and increases serum levels

S: Staph

C: C Diff Diarrhea

R: Rash

E: Enterics

A: Antibiotic

M: not MRSA

S: Strep

GODDAM FIVE COPs IMPACT Ion CLAD FIB

G: binds GABAa Cl- channels

O: Oral

D: Drowsiness

D: Dizziness

A: Anxiety

M: Metabolites are long acting

Increase effect: FIVE COP: Floxetine, Increased, Valproate, Effects, Cimetidine, Oral Contraceptives, Propranolol

I: IV

P: Psychomotor impairment

A: Alcohol withdrawl and some anesthesia

C: Cognitive impariement

T: Tolerance

Ion: Cl- ion channels increased frequency of opening

C: CNS deppressent

L: Lethargy

A: Alchohol increases effects

D: Dizziness

F: Flumazenil (benzo antagonist) reverses effects

I: Ion channel activator (Cl)

B: Benzodiazepine

3 CAP ALOHA!

3: Cox 3 inhibitor

C: Cox inhibitor

A: Analgesia

P: inhibit PG synthesis (less pain and fever)

A: Alcohol increases heptatoxicity (induces formation of hepatotoxic metabolites) 

L: Lacks anti-inflammatory and antiplatelet activity

O: OD can lead to fatal hepatic failure

H: Hepatotoxic

A: Asprins and NSAID's + Acetominophen = additive renal toxicity

DANG PROM

2 LIPS

D: decreased Diuretic effects

A: decrease Angiotensin converting enzyme inbitiors

N: NSAID

G: GI bleeding (less then with other COX inhibitors)

P: increased levels w/drugs that inhibit P450s

R: use: RA

O: use: Osteoarthritis

M: MI as SE

2: COX 2 inhibitor

L: increases Lithium levels

I: use: Inflammatory joint diseases

P: inhibit synthesis of PG's 

S: Stroke as SE

BAD AMALGAM PACTS

B: Brainstem activity (reduce tonic somatic activity via gamma and alpha motor neurons)

A: use: Acute muscle spasms

D: Dizzines, drowsiness, dry mouth

A: additive anticolinergic w/Antihistamines

M: avoid w/MAO inhibitors

A: additive w/Antidepressants

L: Limit duration to several weeks

G: act via Gamma motor neurons

A: act via Alpha motor nuerons

M: Muscle relaxant

P: additive w/Phenothiaine drugs

A: additive w/Atropine

C: acts potentially on CS

T: Tricyclc centrally acting muscle relaxant

Inflix and UNFAIR MIND

U: Upper RTI (SE)

N: N/V (SE)

F: Fatigue (SE)

A: alpha TNF

I: Inactivation

R: RA (use)

M: often used w/Methotrexate

I: IV (q4 wks)

N: No significant interactions

D: Disease modification of RA