Term
|
Definition
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Term
|
Definition
Prevents pro inflammatory leukocytes from reaching CNS
Supresses T-helper cell activity |
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Term
|
Definition
Relapsing MS
Decreases frequency and severity of attacks
Decreases number and size of lesions
Delays progression of disability |
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Term
|
Definition
Flu-like sx
Hepatotoxicity
Myelosuppression
Injection site reactions
Depression
Neutralizing antibodies may decrease effect |
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Term
|
Definition
Titrate/may use Tylenol or NSAIDS to reduce flu-like sx
Monitor liver function tests assess for jaundice
Monitor CBC
Benadryl to reduce injection site reactions. Warm/moist compress after infection |
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Term
| Tecfidera (Tech fi dare a) generic name |
|
Definition
|
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Term
|
Definition
| Protects cells from oxidative stress - anti inflammatory effects |
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Term
|
Definition
Relapsing MS
Reduces relapse rate
Slows disease progression |
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Term
|
Definition
Flushing
GI: Pain/N/V/DI
Infections (decreases lymphocytes)
Flushing/Itching
Caution w/pregnancy |
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Term
| Tecfidera - Teaching/monitoring |
|
Definition
Administer non-EC aspirin 30 min before
Take with food
Monitor/teach infection control
Monitor CBC |
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Term
| Tysabri (tiss a bri) generic name |
|
Definition
| Natalizumab (nat ah liz oooo mab) |
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Term
|
Definition
| Prevents leukocytes from crossing BBB |
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Term
|
Definition
| Relapsing MS, Chron’s disease, Mono tx |
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Term
|
Definition
HA/fatigue/abdominal discomfort
DI, depression, UTI’s,
Progressive multimodal leukoencephalopathy,
Hepatotoxicity
Neutralizing antibodies may lower effect |
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|
Term
| Tysabri - Teaching/monitor |
|
Definition
Unilateral progressive weakness, clumsiness of limbs, disturbed vision and changes in thinking/orientation indicate Leukoencephalopaty BAD.
Monitor for hypersensitivity reactions: rash, fever, chest pain, chills
SSX of infection
Jaundice/liver toxicity signs. |
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Term
|
Definition
| Glatiramer acetate (Glat ear a merr) |
|
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Term
|
Definition
| Suppress inflammatory attack on myelin |
|
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Term
|
Definition
Long term tx for RRMS
Reduce frequency/severity of relapse
Decrease MRI lesions
Delay progression of diesase |
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|
Term
|
Definition
Injection site reactions: pain, redness, itching, pitting
Post injection reactions: Flushing, palpations, chest pain, anx, larynengeal constriction, urticaria-hives (15-20 min after) |
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|
Term
| Gilenya (gill en ya) Generic Name |
|
Definition
| Fingolimod (Fingo le mod) |
|
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Term
|
Definition
Reduces lymphocytes in blood and brain
Reduces inflammation that leads to injury |
|
|
Term
|
Definition
Relapsing forms of MS
Decreases frequency of exacerbation
Delays disability |
|
|
Term
|
Definition
Bradycardia (will decrease with time)
Macular edema (increased in the evening)
Liver injury
Infection risk
Pregnancy: C |
|
|
Term
|
Definition
Long half life - 2 months to reach plateau
Observe pt for first 6 hrs for bradycardia ESPECIALLY heart PTS
Teach PT to report visual changes
Monitor liver labs
Teach/monitor infection |
|
|
Term
| Aubagio (Ah bauge e oh) Generic name |
|
Definition
| Teriflunomide (Tare a flu in a mide) |
|
|
Term
|
Definition
Affects T-cell/B-Cells
Anti inflammatory affects |
|
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Term
|
Definition
Relapsing forms of MS
Decreases relapse rates
Decreases disability progression |
|
|
Term
|
Definition
HA/N/DI
Allopecia
Neutropenia
Hyperkalemia/HTN
Peripheal neuropathy
Renal Failure
Elevated liver enzymes |
|
|
Term
| Augabio - Teaching/monitor |
|
Definition
NOT for pregnancy
Many interactions
Monitor: CBC, electrolytes, CR, Billiruben, liver/kidney labs |
|
|
Term
| Novantrone (No van trone) Generic Name |
|
Definition
| Mitoxantrone (my tox an trone) |
|
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Term
|
Definition
| Decreases destruction of Myelin |
|
|
Term
|
Definition
SPMS
PRMS
Worsening RRMS
Not for PPMS
Reduces MRI lesions
Decreases relapse and disability |
|
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Term
|
Definition
Myelosuppression (infection, no live vaccines 10-14 days after dose)
Cardiotoxicityl
GI injury, N/V
Reversable hair loss, amenorrhea,
Bright green tinting of skin and eyes |
|
|
Term
| Novantrone - teaching/monitoring |
|
Definition
Not for PTS with liver diesase
Not for heart PTS
Hold if neutrophils less than 1500
Hold if left ventricular ejection fraction (LVEF) < 50%
Pregnancy = D!
Scary. |
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