Term
Morphine Sulfate
MS Contin; Duramorph; Astramorph
Name the class of drug that morphine belongs in |
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Definition
| Narcotic-analgesic; opiate; schedule II narcotic; CNS agent |
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Term
Morphine Sulfate
Side effects |
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Definition
CNS: Altered mentation; headache; blurred vision; constricted pupils; paradoxical CNS stimulation; euphoria; drowsiness; syncope
Cardiovascular: bradycardia; hypotension; tachycardia; palpitations
Respiratory: Respiratory depression; respiratory arrest; bronchoconstriction; decrease cough reflex
GI: N/V Abd. cramps; dry mouth; urinary retention
Other: Skin rashes; urinary retention; pupil constriction; facial flushing; localized allergic reaction with IV administration; addiction with long term use |
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Term
Morphine Sulfate:
Contraindications: |
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Definition
Absolute: Known hypersensitivity; altered mentation; head injury; acute alcoholism; acute asthma; exacerbated COPD; hypotension; hypovolemia; monoamine oxidase inhibitors within previous 14 days; increased ICP due to CO2 retention causing cerebral vasodilation
Relative: Seizure disorders; hepatic or renal insufficiency; ingested poisining |
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Term
Morphine Sulfate
(MS Contin, astramorph,duramorph)
Indications: |
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Definition
1.)Cardiac chest pain unresponsive to nitroglycerin.
2.) Severe pain associated with myocardial infarction, kidney stones, etc.
3.) Acute pulmonary edema, CHF with or without associated pain.
4.) Pain associated with isolated extremity fractures, renal colic, burns. |
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Term
Morphine Sulfate
(MS Contin, Astramorph, Duramorph)
Action:
Onset:
Duration |
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Definition
1.) Binds with opiate receptors in the sensory cortex of the frontal lobes and diencephalon, altering both perception and emotional response to pain.
2.)Secondary pharmacologic effects of morphine include depressed responsiveness of alpha adrenergic receptors (producing peripheral vasodilation) and baroreceptor inhibition.
3.) Reduces anxiety, respiratory effort, preload, afterload, and cardiac workload thus decreasing myocardial oxygen demand
Onset: less than 1 minute with peak at 7 to 10 minutes.
Duration: 4 to 8 hours |
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Term
Morphine Sulfate
Dosage
Route |
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Definition
Adult dosage:
Cardiac: 2 to 5 mg SIVP @ 1 mg/minute (repeat every 3 to 5 min. until pain is relieved or respiratory depression occurs.
Pain Relief: .1 mg/kg loading dose titrated to effect.
Pediatric Dosage: .05 to .1 mg/kg over 5 minutes. Maximum dose is 15 mg.May repeat every 2 hours p.r.n.
Route: IVP; IO |
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Term
Morphine Sulfate:
Pregnancy Safety? |
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Definition
Negative ghostrider the pattern is full!
Class C |
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Term
Morhpine Sulfate:
Interactions: |
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Definition
1.) Central nervous system depressants, tricyclic antidepressants, alcohol, antihistamines, barbiturates, beta blockers, and chlorpromazine may potentiate effects
2.) MAOI drugs may cause paradoxical excitation
3.) Do not mix with aminophylline, meperidine, or sodium bicarbonate
Vagotonic effects (bradycardia, heart blocks)
Hypotension may develop in volume depleted patients
Can cause bronchoconstriction |
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