Term
Lithium
(Eskalith)
Advantages x 3 |
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Definition
-Effective
-not typically associated with weight gain
-only mood stabilizer to decrease suicidality |
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Term
| Lithium, test prior to starting x 5 |
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Definition
-CBC
-EKG
-Preg test
-TFT
-BMP--kidney |
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Term
|
Definition
-hyperkalemia, ekg
-polyuria
-polydipsia
-sedation
-tremor
-benign leukocytosis
-acne |
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Term
|
Definition
Nephrogenic DI, renal impairment
-thyroid dysfunction
hydrochlorothyazide and spiralactone increase lithium blood level |
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Term
Lithium onset of action
therapeutic leves |
|
Definition
5-7 days
.6 to 1.2
toxic >1.5
lethal >2 |
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Term
|
Definition
| diuretics and nsaids (ibuprofen) |
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Term
|
Definition
n/v/d
tremor
ataxia
MS changes
renal failure
convulsions
coma |
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Term
Valproic acid
common SEs x 3 |
|
Definition
"Depakote"
-sedation
-weight gain
-alopecia |
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Term
|
Definition
hepatotoxicity
thrombocytopenia |
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Term
|
Definition
| slightly wider therapuetic window compared to lithium |
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Term
|
Definition
-blood draws to monitor levels
-platelets
LFTs
-teratogenic |
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Term
|
Definition
-n/v
-ataxia
-eye movement abnormalities
-lethargy
-coma |
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Term
|
Definition
-lithium
-lamotrigine
-olanzapine
-quetiapine |
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Term
|
Definition
-VPA (Divalproex)
-apriprazole |
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Term
|
Definition
"Tegretol"
-bone marrow suppression
-many drug interactions
P-450 inducer, induces own metabolism
OCP interaction, decrease OCP and teratogen
maybe Stevens Johnson |
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Term
|
Definition
"tegretol"
-trigeminal neuralgia
-blocks sodium channel and inhibit action potential
-onset of action 5-7 days
-CBC and LFT check and monitor |
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Term
|
Definition
"Lamictal"
-useful in bipolar depression
-must titrate slowly
-risk of Stevens-Johnson syndrome |
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Term
|
Definition
| decreases VPA levels and VPA increases Lamictal levels |
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Term
|
Definition
"Topamax"
-can promote weight loss
-also for headaches
-Dopamax--cognitive SEs
-Kidney stones |
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