Term
| What to use for maintenance therapy for bipolar? |
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Definition
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Term
| What to use for acute episodes of mania? |
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Definition
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Term
| What to use for severe mania? |
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Definition
Atypical antipsychotics - olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole lithium/valproic acid
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Term
| What to use for severe depression in bipolar? |
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Definition
Lithium or lamotrigine Bupropion if REALLY bad
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Term
Lithium Mechanism, pkin/ddi |
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Definition
Mech: Block recycling of PIP2, especially works in brain. Also inhibits release of norepi, dopamine, increases 5-HT synthesis, uncouples G-proteins, alters electrical gradients Pkin - ion, so excreted renally.Diuretics, ACEi inhibit excretion so increase concentration, slow onset of action |
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Term
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Definition
Nausea, diarrhea, acne, drowsiness, polyuria, polydipsia, weight gain. Tremor, ataxia, aphasia, bizarre movements, confusion at high conc - renal impairment Intereferes w/vasopressin - nephro diabetes insipid Interferes with TSH Some badness w/pregnancy |
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Term
| Atypical antipsychotic uses in bipolar |
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Definition
manic, mixed episodes - olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole Bipolar depression - olanzapine, quetiapine Maintenance - continue acute therapy above
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Term
Atypical Antipsychotics Adverse effects |
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Definition
Weight gain, type 2 diabetes, dyslipidemia, hyperprolactinemia, extrapyramidal sx, QTc prolongation, confusion, drowsiness, drug-drug interactions - CYP inhibitors |
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Term
| Uses of Clonazepam, lorazepam in bipolar |
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Definition
Management of mania in combo w/mood stabilizers |
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