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Mood disorders Part I
Depression
122
Nursing
Graduate
06/18/2011

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Cards

Term
"affect" might also be described as ______ or ______ reaction to an experience
Definition
mood; emotional reaction
Term
Examples of affect: depression, ____, ____, ____
Definition
depression, joy, anger, anxiety
Term
______ is the oldest, most frequently described psychiatric illness
Definition
Depression
Term
______ symptoms are normal, healthy responses to every day disappointment
Definition
transient
Term
_______ depression occurs when an adaptation is ineffective
Definition
pathological depression
Term
_______ ________ is the consequence of dysfunctional grieving
Definition
pathological depression
Term
Major depression affects almost __% of the population. Depression is higher in _______ (men/women) by about _ to _. Its is more common in ____(young/older) _______.
Definition
10% of the population, higher in women by 2 to 1, more common in older woman (than younger)
Term
In terms of social class, there is an ________ ________ between social class and report of depressive symptoms. ______ social status is more likely to report. The ________ is true of ________.
Definition
Inverse relationship, higher social status is more likely to report, opposite of bipolar.
Term
Who is most likely to be depressed: single, divorced, or married people?
Definition
Single or divorced
Term
Which season is most often associated with seasonal depression? What are some reasons this might be true?
Definition
Spring and fall. "Turning points" in lives may trigger depression (starting school, graduating).

Also, variations in serotonin produced in spring and fall.
Term
Incidence of depression is __ higher in first relatives of people diagnosed. People with _______ _______ usually have a relative with it.
Definition
3 times higher.

Bipolar disorder.
Term
What are the three types of depressive disorders?
Definition
Major depressive disorder
Dysthymic disorder
Premenstrual dysphoric disorder
Term
To be diagnosed with Major Depressive disorder (MDD), a person must have __(#) symptoms present in the same _ _____ period and symptoms must represent a _____ from ______ _________.
Definition
5, same 2 week period, change from previous functioning
Term
**Of the 5 symptoms present in MDD, what MUST be one of them?

The person must have
Definition
Decreased/depressed mood or loss of interest in pleasure.
Term
There are nine possible symptoms of MDD, of which four MUST be present. What are the nine?
Definition
1. Depressed most of the day, nearly every day
2. Decreased interest in most activities, nearly every day
3. 5% weight loss or gain in one month period*
4. Insomnia or hypersomnia most days
5. Psychomotor agitation or retardation most days
6. Fatigue or low energy most days
8. Feeling worthless or guilty most days
9. Impaired concentration most days
10. Recurrent thoughts of death or suicide most days
Term
In addition to the qualifying symptoms of MDD, _______ may be present. This is NOT present in DD.
Definition
Psychosis
Term
To be diagnosed with MDD, the patient must have no history of ____ ______, and it cannot be attributed to use of __________ or a ______ _______ ______.
Definition
No history of manic behavior, cannot be attributed to use of substances or general medical condition
Term
MDD may be ____ _____ or just a ______ _______.
Definition
Long term or just a single episode
Term
Dysthymic Disorder is similar to major depression, but with ____ symptoms.
Definition
Milder
Term
There is NO evidence of ________ ________ in DD.
Definition
psychotic symptoms.
Term
The essential feature of DD is a chronically depressed mood for ___________, more __________, and for at least __ _____. Though some people may have it ___________-- maybe every ______ for __ years.
Definition
Most of the day, more days than not, for at least 2 years.

Some may have it seasonally, like every spring for at least two years.
Term
Some various symptoms of DD are: decreased ________, _____ disturbances, low ____ ______, difficulty ________.
Definition
Decreased appetite, sleep disturbances, low self-esteem, difficulty concentrating
Term
The essential features of Premenstrual Dysphoric Disorder (PMDD) are: ______ _______, _____, mood _____, decreased interest in _______.

What time must these symptoms occur and end?
Definition
Depressed mood, anxiety, mood swings, decreased interest in activities.

*Symptoms appear the week before menses and end shortly after.
Term
Bipolar disoered is characterized by mood swings that vary from _____ _______ to _______ _______, with intervening periods of _______. The "high" period may be a _____-high, or it may be ______ and _________.
Definition
Profound depression to extreme euphoria, with periods of normalcy.

*The high period may be a happy-high or it may be irritation and aggressiveness.
Term
_____ or ______ may or may not be present in bipolar disorder.
Definition
Delusions or hallucinations may or may not be present.
Term
Symptoms of bipolar may occur at what time?
Definition
They may be seasonal.
Term
To be diagnosed as having mania, the patient MUST have: a distinct period of abnormally ________ or _________ mood lasting __ ____ or more AND _ of the following: _______ self-esteem, decreased _____ ___ ______ (< _ hours/night), extreme _________, ______ thoughts, destructibility, very _____-______ behavior, craving _____ behavior without _______________. *
Definition
Expansive or irritable moor lasting 7 days or more.

3 of the following: increased self-esteem, decreased need for sleep, (<3 hours night), extreme talkativity, racing thoughts, distractability, very goal-directed behavior, craving pleasurable activities without worry about consequences*
Term
The difference between bipolar I and II is that bipolar I has less severe ______. However, the ___ are just as ___.
Definition
Bipolar I has less severe mania, the lows are just as low, though.
Term
Between episodes, both ______ _ and _ have a ______ period that lasts up to years until there is a ______.
Definition
Bipolar I and II, euthymic period lasts up to years until there is a trigger.
Term
______ _____ is a chronic mood disturbance that lasts at least 2 years*. There are numerous episodes of ______ and ____ _____, and the breaks in symptoms are __ 2 _____*.
Definition
Episodes of hypomania and depressed mood with breaks in symptoms less than or equal to 2 months.
Term
Other mood disorders may be due to a _____ ______ condition like __________.

A mood disorder may also be ______-induced, like _____/_____ from drugs or _____. A mood disorder may also be from environmental exposure like ____ such as ____ in the job.
Definition
General medical condition like hypothyroidism

substance-induced mood disorder like intoxication or withdrawal from drugs or alcohol. Metals such as mercury in the job.
Term
Some nutritional deficiencies that could contribute to mood disorders are in: low ___ or ___ vitamins, or low ___ ____.
Definition
B or C vitamins, low folic acid
Term
State the "Learned helplessness theory."
Definition
Repeated heartbreak or failure to control life leads to defeat and dependence on others, resulting in predisposition to depression
Term
What is the object loss theory? What does the patient feel? What is an example?
Definition
Person experiences a loss of a significant other during the first 6 months of life. The person feels helplessness and despair. The early loss or trauma may predispose client to episodes of depression in response to losses later in life.

An example is loss or detachment from mother in babies that weren't held enough in the first 6 months.
Term
What is the Cognitive theory?
Definition
Views that primary disturbances in depression as cognitive, rather than affective. Negative thinking causes depression. In this theory, 3 cognitive distortions serve as a basis for depression: negative expectations about environment, self, future.
Term
___ _____ is probably the best etiological theory about mood disorders
Definition
Theoretical integration (multiple influences)
Term
Symptoms of depression age < 3: ______ problems, _______, lack of ______ and emotional _______.
Definition
Feeding problems, tantrums, lack of playfulness and emotional expressiveness,
Term
Symptoms of depression in ages 3-5: ______ proneness, _______, excessive _____-_____.
Definition
Accident proneness, phobias, excessive self-reproach ("I was bad, mommy" a lot)
Term
Symptoms of depression ages 6-8.
________ ______
________ and/or _______ behavior
Definition
Physical complains, aggressive and or clinging behavior.
Term
Symptoms of depression ages 9-12
Definition
Morbid thoughts and excessive worrying
Term
Situations that may precipitate childhood depression
Definition
Death of a parent or pet, divorce, academic failure, major illness like cancer
Term
The focus of therapy in depression in children is to ________ ________ and strengthen ________ _____. Two good therapies are _____ therapy, ______ and ______ therapy.
Definition
Alleviate symptoms and strengthen coping skills. Talk therapy, parental and family therapy.
Term
Symptoms of depression in adolescence.

What is the best indicator
Definition
Inappropriate anger, aggressiveness
Running away repeatedly
Delinquency
Sexual acting out
Substance abuse
Restlessness
Apathy

*the best indicator is social withdrawal. These kids have been very social and suddenly want to stay in their room all the time. They don't want to see friends or family.
Term
What is the best clue that differentiates depression from normal, stormy adolescent behavior?
Definition
A visible manifestation of behavioral changes that lasts for several weeks
Term
What is the most common precipitant to adolescent suicide?
Definition
A perception of abandonment by parents or close peer relationship
Term
Usually, children are not treated with _____ because they can increase ______ ________. ________ is the one ______ that is approved by the FDA.
Definition
Not treated with medication because they can increase suicidal thoughts. Prozac is only med approved by FDA for children.
Term
In the older population, depression is often confused with ______
Definition
Dementia
Term
_____ ______ is what happens as a person ages and many peers, friends, and family start dying around you.
Definition
Bereavement overload.
Term
In elderly, there is a ___ _____ or suicides.
Definition
high percentage
Term
Postpartum depression may last for __ ____ to ___ ____. It is associated with ______ changes, _______ metabolism or ____ alterations. One major symptoms is a concern about what?
Definition
May last a few weeks to several months, associated with hormonal changes, tryptophan metabolism, or cell alterations.

Concern about ability to care for infant.
Term
While assessing a person with ____ depression, the nurse may note the "blues," reports crying from time-to-time, has difficulty getting mind off their own disappointment, and feeling tired and listless
Definition
Transient depression
Term
_____ _______ is associated with normal grieving.

The person may feel anger, anxiety and sadness. They may be tearful and regress to an earlier stage of development. Preoccupation with loss, blame of self and others, anorexia and overeating, sleep disturbances, somatic symptoms.

What is the treatment
Definition
Mild depression. No treatment at this level.
Term
________ depression is associated with Dysthymic Disorder
Definition
Moderate
Term
With moderate depression, how does the client feel and present?
Definition
Helpless, powerless, slow physical movement, slumped posture, limited verbalization, *may "self-medicate" with alcohol and drugs. Their thinking is retarded and they have difficulty concentrating.

They may have anorexia or overeating, sleep disturbances, somatic symptoms, feel best early in the morning and get worse as day progresses*

May be angry ant self and others
Term
Severe depression involves symptoms of ____ and _____.
Definition
MDD and bipolar disorder.
Term
A person with severe depression may have a ____ affect, feelings of _____ _____, _______, apathy and anhedonia. ______ retardation. They may be in the _____ __ position. May not ____ or ______. They may have ________ ______, but usually don't have the energy to carry out a plan. They feel worse in the _____ than the _____*.
Definition
Flat affect, feelings of total despair and worthlessness, apathy, psychomotor retardation, curled-up position, may stop moving or speaking, suicidal thoughts, they feel worse in the morning than the evening.
Term
In severe depression, _____ may be present
Definition
delusions
Term
Four classifications of antidepressants
Definition
1. Tricyclics
2. Monoamine Oxidase Inhibitors (MAOIs)
3. Selective Serotonin Reuptake Inhibitors
4. Atypical Antidepressents
Term
Tricyclic antidepressants are used to treat symptoms of _______, as well as for _____ disorders
Definition
Symptoms of depression. Also used for anxiety disorders like panic attacks, phobic disorders, OCD.
Term
Half-life for tricyclic antidepressants
Definition
20-126 hours. They are given once daily.
Term
Tricyclic antidepressents work by blocking _____ of neurotransmitters at _______ neurons.
Definition
Block re-uptake of neurotransmitters at presynaptic neurons.
Term
At what level does a person develop a tolerance to tricyclic antidepressants?
Definition
NEVER! The level must be therapeutic, but tolerance does not develop. OVERDOES IS LETHAL.
Term
Tricyclics are used with caution in ____ because of ______ effects like _____.
Definition
Caution with elderly because of cardiac effects like arrhythmias.
Term
Tricyclics are widely used for _____, but are not approved by the FDA for such use.
Definition
children.
Term
Tricyclics are not recommended during ________ and _______.
Definition
Pregnancy and lactation
Term
CONTRAINDICATION for tricyclic use? (6)
Definition
Cardiovascular disease, glaucoma, BPH, liver disease, renal disease, seizure disorder (lowers the seizure threshold)
Term
Prior to taking tricyclics, what test should the patient have?
Definition
Baseline ECG is recommended
Term
When taken with warfarin, tricyclics may cause increased ____
Definition
Bleeding
Term
Tricyclics should NEVER be given with ____ due to _______ ____, _______ _____, and _____ ______.
Definition
Hypertensive crisis, hyperpyretic crisis, and severe seizures
Term
What are some common anticholenergic side effects from tricyclics?)

What is some patient teaching to prevent/treat antocholinergic side effects?
Definition
Urinaty retention, dry mouth, constipation, blurred vision.

Tell client to report bladder fullness, assess for distention (may want to do I&O), H2O mouth rinses, sugarless gum/candy, drink H20, increase fiber and exercise, avoid driving or operating heavy machinery until blurred vision subsides
Term
Common cardiovascular side effects (tricyclics) and patient teaching
Definition
Arrhthmias, prolonged QRS, heart failure: teach client to report lightheadedness, dizziness, racing pilse, assess radial and apical pulses, teach client and family to take pulse*

Hypertension: monitor BP

Postural hypotension: change positions slowly, assess orthostatic BP
Term
*Signs of TCA overdose*
Definition
Sedation, ataxia, agitation, stupor, coma, convulsions, respiratory depression, death
Term
Treatment for TCA overdose:
Definition
Maintain airway, cathartics or gastric lavage with activated charcoal, give Antilirium (physostigmine), monitor VS and ECG
Term
Which drug do we give for TCA overdose?
Definition
physostigmine (Antilirium)
Term
Agranulaocytosis, seizures, and serotonin syndrome are ______ side effects of ___s. You need to ____ ___ ____ ASAP.
Definition
Serious side effects of TCAs. Stop the drug ASAP.
Term
What are the symptoms of serotonin syndrome?
Definition
Hypothermia, hyperflexia, tachycardia, diaphoresis, decreased LOC (due to increase of serotonin bioavailability)
Term
If a patient is switching between MAOIs and SSRIs, the nurse must ensure there is a ___ ____ "_____ period" to let tricyclics out of the system
Definition
4-6 week washout period.
Term
If a patient shows signs of serotonin Syndrome, the nurse should _____ ______ ____ (FIRST) administer ____ ____ _____, as well as ____ and meds for _________ support and prepare the client for ____
Definition
Stop the drug FIRST
administer serotonin receptor antagonist, Iv fluids and meds for cardiovascular support,

***Prepare client for transfer to ICU
Term
MAOIs work by _______ serotonin and _______ at the ______
Definition
breaking down serotonin and norepinephrine at the synapse
Term
MAOIs have _____, _________ side effects.
Definition
Serious life-threatening side effects. They are not used often.
Term
Phenelzine (Nardil), isocarboxazid, tranylcypromin (Parnate)
Definition
MAOIs
Term
What is the serum half life for MAOIs?
Definition
Unknown. The therapeutic effect is reached in a couple of weeks.
Term
MAOIs and elective surgery
Definition
Discontinue at least 2 weeks due to risk of severe hypotension when anesthesia is given
Term
Over the counter ____ ____ may cause added ________ effects when taken with MAOIs, as well as foods that contain _____
Definition
cold peperations, sympathomimetic effects


Tyramine
Term
Severe headache at the back of the head (occipital), N/V, elevated BP, photophobia, dilated pupils, arrhythmias/palpatations are symptoms of ______, and the nurse should ____ ___ _____.
Definition
Hypertensive crisis. Stop the medication.
Term
Why shouldn't a person taking MAOIs consume beer, wine, coffee, or tea?
Definition
They interfere with MAOI activity.
Term
Foods containing Tyramine
Definition
Brewer's yeast, broad beans, fava beans, pickles and saurkraut (vinegar), bananas, figs, raisins, cheese, yogurt, chicken lievers, smoked salmon, snails, chocolate, licorice, soy sauce, any processed meats, grapes, oranges, pineapples, plums, leftovers!!!
Term
Drugs to avoid with MAOIs
Definition
over the counter cold, cough and allergy drugs, prescribed psychostimulants, street drugs such as cocaine and amphetamines
Term
SSRIs only effect the neurotransmitter _____, therefor they do not have the same side effects as MAOIs, TCAs, or antipsychotics
Definition
Serotonin
Term
Half life of SSRIs?

How long does it take to reach therapeutic effectiveness
Definition
20-168 hours. Can be given QD. 2-4 weeks
Term
Tolerance to SSRIs
Definition
NO tolerance, LOW potential for OD
Term
Contraindications for SSRIs
Definition
Hypersensitivity reactions
Severe hepatic or renal failure
Seizure
DM
Term
Interactions with SSRIs. Added CNS depression:
Definition
alcohol, antihistamines,
Term
Added serotonergic effects
Definition
TCAs, MAOIs
Term
SSRIs increase the toxicity of these drugs
d____
d____
l____
c____
Definition
digoxin
dilantin
lithium
coumadin
Term
Some common side effects and nursing interventions are:
______, for which the patient may take SSRI in the ___ and they should eliminate ____. For a ______, the patient may take_________ as RX'd. For _________, the nurse should encourage the patient to consume _______ calories. The only solution to _______ _________ is to switch to another antidepressant.
Definition
Insomnia--> take SSRI in AM, eliminate caffeine.
Headache---> analgesics as RX'd
Weight loss__> adequate calories
Sexual dysfunction___> switch to another antidepressant
Term
Common side effects of heterocyclics
Definition
N/V---> give with food, increase fulids
Restless/insomnia--->take in AM
Weight GAIN---> encourage sugar free beverages and hard candy, balanced nutrition, and exercise
Term
Bupropin (Zyban, Wellbutrin)
Definition
Heterocyclic, also used for smoking cessation
Term
Malprotiline (Ludiomil)
Definition
Heterocuclic
Term
Mirtazipine (Remeron)
Definition
Heteroocyclic
Term
Trazodone (Desyrel)
Definition
Heterocyclic
Term
SNRIs
Definition
Serotonin-Norepinephrine Reuptake Inhibitors
Term
Duloxetine (Cymbalta)
Venlafaxine (Effexor)
Desvenlafaxine succinate (Pristiq)
Definition
SNRIs
Term
COMMON side effects of SNRIs
Definition
Elevated BP and pulse--->monitor vs
N/V, dry mouth---> take with food, increase p.o fluids
Drowsiness or insomnia--->time as appropriate
Term
Antidepressents may increase _______ _______ or behaviors in some children, teenagers, and young adults, especially in the first ______ ______ or when ______ is ________. Patients and their families and caregivers should watch for new or ______ _____ of depression.
Definition
Increase suicidal thoughts, especially in the first few months of treatment or when dose is changed.

Watch for new or worsening depression symptoms, changes in behavior, thoughts of suicide. Report symptoms right away, especially if severe or sudden.
Term
ECT is effective for clients who...?

It is used when ______ response is needed. Examples are if the patient is ______/________ or have extreme _______/________
Definition
Don't respond to other treatment.

When rapid response is needed, like suicidal/homicidal or extreme agitation/stupor
Term
What is the best treatment for depression in a woman who is in the first trimester of pregnancy?
Definition
ECT, when other meds are contraindicated
Term
How does ECT work?
Definition
It is unclear WHY it works. However, seizures increase neurotransmitters, restore circadian rhythm and restores equilibrium between brain hemispheres
Term
Contraindications for ECT
Definition
Brain tumors, increased intracranial pressure
Term
Use ECT CAUTIOUSLY (not contraindicated) in clients with: recent ___, _______, acute ______ _____, cardiac ______. thrombophlebitis, and _____.
Definition
Recent MI, aneurysms, acute respiratory infection, cardiac arrhythmia, thrombophelebitis, glaucoma*
Term
The current in ECT lasts less than __ ______. It is given ____ times per ____, for a total of __-__ treatments. The patient may have some _____ ____. which usually is _______/
Definition
2 seconds
Given 3 times/ week, total of 6-12 treatments
Some memory loss, which is usually temporary
Term
Nursing actions for ECT: keep client ____, set up _____, ____ chart, ______. Remove ____ objects, ______, jewelery. Client must _____. _______ lock in place. Connect ______ and _____ ________, EEG and EKG and _____ line.
Definition
Keep client NPO. Set up suction, code chart, defibrillator. Remove metal objects, dentures, jewelery. Client voids. Bite lock in place. Connect O2 and pulse oximetery, EEG, EKG and I.V. line.
Term
For ECT _____ is given to reduce secretions and bradycardia
Definition
Atropine
Term
For ECT, _____ is given as a muscle relaxant
Definition
Anectine
Term
in ECT ______, _____, ______ are used as short-acting anesthesia
Definition
Brevitol, Versed, pentothal
Term
_____(male/female) are more likely to commit suicide.
Definition
Male
Term
The two age groups that have higher risk of suicide are____ and ________
Definition
Adolescent and older than 50
Term
Those with a previous ____ are at increased risk for suicide, along with those who abuse ______, have a presence of a _____ _____, lack of a ___ ____, a marital status of _________ (3), presence of ____ ____ ESPECIALLY *chronic ____ ______
Definition
Previous attempt, abuse substances/alcohol, presence of a thought disorder, lack of support system, unmarried-divorced-or widowed, physical illness ESPECIALLY chronic organized pain
Term
Living alone, unemployment, recent loss, recent surgery including childbirth, social disgrace and family hx-- increase risk of...?
Definition
Suicide (not hereditary, but higher risk in family members)
Term
In terms of timing, when is suicide most likely to occur?
Definition
When going into or coming out of a depression
Term
To establish a supportive relationship with the client, the nurse should align himself/herself with the part of the client that ____ __ ____, as well as _____ ______ closely and using _____ precautions.
Definition
Part of client that wants to live, as well as monitoring closely and using suicide precautions.
Term
Prozac (fluoxetine)
Definition
SSRI, only FDA approved antidepressant for children/teens
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